A5061048010- Advanced Breast Cancer Therapies
- Breast Cancer Treatment Studies
- Inflammatory Biomarkers in Disease Prognosis
- Cancer-related Molecular Pathways
- Prostate Cancer Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- HER2/EGFR in Cancer Research
- Glioma Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Renal cell carcinoma treatment
- COVID-19 and healthcare impacts
- Cancer Treatment and Pharmacology
- Cancer Immunotherapy and Biomarkers
- Connexins and lens biology
- Case Reports on Hematomas
- Cancer, Lipids, and Metabolism
- Body Composition Measurement Techniques
- Hedgehog Signaling Pathway Studies
- Economic and Financial Impacts of Cancer
- Liver Disease Diagnosis and Treatment
- Trace Elements in Health
- Advanced Radiotherapy Techniques
- Genital Health and Disease
Medical Park Gaziantep Hospital
2024-2025
Kocaeli Üniversitesi
2021-2025
Gaziantep University
2018-2021
There is no standard treatment recommended at category 1 level in international guidelines for subsequent therapy after cyclin-dependent kinase 4/6 inhibitor (CDK4/6) based therapy. We aimed to evaluate which oncologists prefer patients with disease progression under CDKi. In addition, we show the effectiveness of systemic treatments CDKi and whether there a survival difference between hormonal (monotherapy vs. mTOR-based).A total 609 from 53 centers were included study....
Background and Objectives: Early-onset breast cancer (EOBC), particularly in patients under 40, presents with distinct biological characteristics worse survival outcomes compared to late-onset cases. Despite intensive treatments, EOBC patients, especially those hormone receptor-positive, HER2-negative (HR+/HER2-) subtypes, show poorer prognosis. CDK4/6 inhibitors, combined endocrine therapy (ET) have become the standard for HR+/HER2- metastatic cancer, yet younger are underrepresented...
Objective: Extensive-stage small-cell lung cancer (ES-SCLC) is an aggressive malignancy with a poor prognosis, for which prognostic factors are being investigated. In this study, we aimed to evaluate the significance of Lung Immune Prognostic Index (LIPI) in ES-SCLC patients. Patients and Methods: Our retrospective study evaluated 60 patients who were followed-up treated between 2014 2022 whose data could be accessed. Demographic characteristics, treatments laboratory parameters (lactate...
Background and Objectives: This study aimed to evaluate the prognostic significance of pre-treatment albumin-to-alkaline phosphatase ratio (AAPR) in early-stage colorectal cancer patients compare it with neutrophil-to-lymphocyte (NLR) platelet-to-lymphocyte (PLR) within same patient cohort. Materials Methods: retrospective included 540 who were followed up after a diagnosis whose albumin (ALB), alkaline (ALP), neutrophil, platelet, lymphocyte values measured before treatment. Results: In...
Background/Objectives: Renal cell carcinoma (RCC) accounts for 2-3% of all cancers, with approximately 25% patients being detected at the metastatic stage. This study aimed to determine prognostic significance co-evaluating two risk parameters: one, HALP score based on haemoglobin, albumin, lymphocyte, and platelet counts, other, albumin-to-alkaline phosphatase ratio (AAPR) in RCC treated targeted therapy. Methods: retrospective cohort included 147 RCC. The AAPR values were calculated from...
Ribociclib, palbociclib and abemaciclib are currently approved CDK4/6 inhibitors along with aromatase as the first-line standard-of-care for patients hormone receptor-positive, HER2-negative metastatic breast cancer.
Metastatic castration-resistant prostate cancer (mCRPC) remains a challenging condition to treat despite recent advancements. This retrospective study aimed assess the activity and tolerability of Lutetium-177 (Lu-177) PSMA-617 radioligand therapy (RLT) in mCRPC patients across multiple centers Turkey. The included 165 who received at least one cycle Lu-177 RLT, with majority having bone metastases undergone prior treatments. Prostate-specific antigen (PSA) levels were assessed before each...
This study is aimed to investigate the prognostic significance of inflammation indices, including neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte (MLR), platelet-to-lymphocyte (PLR), systemic immune-inflammation index (SII), and pan-immune-inflammation value (PIV) in metastatic castration-resistant prostate cancer (mCRPC) patients who had received lutetium labeled prostate-specific membrane antigen ( 177 Lu–PSMA-617) therapy. Sixty-one mCRPC Lu–PSMA-617 treatment followed up...
The only phase 3 study on the effectiveness of CDK 4-6 inhibitors in first-line treatment premenopausal patients with hormone receptor (HR) positive, HER2 negative metastatic breast cancer is MONALEESA-7 study, and data palbociclib limited. Data are also limited regarding whose dose was reduced due to neutropenia, most common side effect inhibitors. In our we aimed evaluate ribociclib reduction neutropenia progression-free survival. Our a multicenter, retrospective factors affecting survival...
This study aims to report the efficacy and safety of capecitabine plus temozolomide (CAPTEM) across different lines treatment in patients with metastatic neuroendocrine tumors (NETs).
Real-world (RW) data provide valuable information about the effectiveness and safety of treatment modalities in general population that is not limited by selection criteria clinical studies. The aim this study was to evaluate palbociclib or ribociclib plus fulvestrant hormone receptor-positive human epidermal factor 2-negative metastatic breast cancer (HR+/HER2-MBC). We conducted a multicenter, retrospective cohort included 522 patients with HR+/HER2-MBC treated combination fulvestrant....
In the REGOMA trial, regorafenib demonstrated an overall survival advantage over lomustine, and it has become a recommended treatment for recurrent glioblastoma in guidelines. This study aimed to evaluate effectiveness safety of as third-line patients with who progressed while taking bevacizumab-based therapy. retrospective, multicenter Turkey included 65 treated between 2021 2023 across 19 oncology centers. The main inclusion criteria were histologically confirmed isocitrate dehydrogenase...
As a result of technological developments in healthcare services, telemedicine is becoming widespread. We aimed to determine the effect COVID-19 on Turkish medical oncologists' opinions through survey.This study was conducted using an online questionnaire linked invitation e-mail sent members Medical Oncology Association mailing group between May and July 2020.Of 110 (73 males 37 females) oncologists who answered questionnaire, average age 43.9 ± 7.29 (range: 31-64) years, majority...
No studies have evaluated the interaction, quality, and reliability of chemotherapy-related videos published on YouTube. The aim was to evaluate content YouTube about chemotherapy using 5 different scoring tools. In this cross-sectional register-based study, popular following keywords were examined; "chemotherapy," "what is chemotherapy," "types "chemotherapy side effects" treatments." Quality video measured modified DISCERN (mDISCERN), Journal American Medical Association (JAMA), Global...
To investigate anterior segment parameters in patients with Wilson disease (WD).In this cross-sectional study, 22 WD (study group) and healthy subjects (control were enrolled. Each participant underwent a comprehensive ophthalmic assessment including best-corrected visual acuity, slit-lamp biomicroscopy, fundus examination, intraocular pressure. Anterior measured by the Sirius analyzer system (Costruzione Strumenti Oftalmici, Florence, Italy).Mean central corneal thickness was 522 ± 47 μm...
Many developing countries lack access to recommended first-line treatments for metastatic renal cell carcinoma (mRCC), such as immune checkpoint inhibitors (ICIs) or ICI-tyrosine kinase inhibitor (TKI) combinations. As a result, predictive markers are necessary identify patients who may benefit from single-agent TKIs long-term response. This study aims parameters. was multi-centre, retrospective of with mRCC were undergoing treatment sunitinib pazopanib. Patients had been diagnosed and not...
Aim: Metastatic renal cell carcinoma (mRCC) with lung metastases is associated poor prognosis, and there a growing interest in systemic inflammatory markers as potential prognostic indicators. This study evaluates the significance of Systemic Immune-Inflammation Index (SII), Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to- Lymphocyte (PLR), Advanced Lung Cancer Inflammation (ALI) patients mRCC. Material Methods: In our retrospective multicenter study, we analyzed 76 mRCC isolated...
Coronavirus related lockdown measures had a severe psychological toll. We investigated the effects of population-wide infection control on hemodialysis (HD) and oncology patients' mood statuses.An electronic survey was used to collect data. Profile Mood States (POMS) Hospital Anxiety Depression Scale (HADS) measure statuses.The study groups composed 400 HD, 234 patients, 276 controls. HADS anxiety total POMS scores were significantly higher in group than that both HD finding consistent with...
Background Triple negative breast cancer (TNBC) is characterized by high rates of recurrence, especially in patients with residual disease after neoadjuvant chemotherapy (NAC). Capecitabine being used as standard adjuvant treatment TNBC. We aimed to investigate the real-life data regarding efficacy capecitabine
Objective: To assess the impact of surgical delay in localized prostate cancer (PCa) on adverse pathological features and oncological outcomes.Materials Methods: Patients who underwent surgery for PCa were included from Turkish Urooncology Association database.History previous treatment or active surveillance was considered an exclusion criterion.Patients divided into two groups according to time period between diagnosis surgery; less than equal 90 days (group 1) longer 2).Surgical pathology...