Numan Görgülü

ORCID: 0000-0003-3776-885X
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Research Areas
  • COVID-19 Clinical Research Studies
  • Dialysis and Renal Disease Management
  • Muscle and Compartmental Disorders
  • COVID-19 and healthcare impacts
  • Renal and Vascular Pathologies
  • Long-Term Effects of COVID-19
  • Renal Transplantation Outcomes and Treatments
  • Renal Diseases and Glomerulopathies
  • Pharmacological Effects and Toxicity Studies
  • Parathyroid Disorders and Treatments
  • Vasculitis and related conditions
  • Transplantation: Methods and Outcomes
  • Neurological Complications and Syndromes
  • Hemoglobinopathies and Related Disorders
  • Regulation of Appetite and Obesity
  • Iron Metabolism and Disorders
  • Child Abuse and Related Trauma
  • Gout, Hyperuricemia, Uric Acid
  • Cardiac pacing and defibrillation studies
  • Central Venous Catheters and Hemodialysis
  • Chronic Kidney Disease and Diabetes
  • Abdominal Surgery and Complications
  • Organ Transplantation Techniques and Outcomes
  • Abdominal vascular conditions and treatments
  • Organ Donation and Transplantation

Bağcılar Eğitim ve Araştırma Hastanesi
2016-2025

Sağlık Bilimleri Üniversitesi
2021-2024

Universidad CES
2024

Istanbul Memorial Hospital
2013

Istanbul University
2007-2012

Abstract Background Maintenance hemodialysis (MHD) patients are at increased risk for coronavirus disease 2019 (COVID-19). The aim of this study was to describe clinical, laboratory, and radiologic characteristics determinants mortality in a large group MHD hospitalized COVID-19. Methods This multicenter, retrospective, observational collected data from 47 nephrology clinics Turkey. Baseline laboratory radiological characteristics, COVID-19 treatments during hospitalization, need intensive...

10.1186/s12882-021-02233-0 article EN cc-by BMC Nephrology 2021-01-14

Abstract Background We aimed to present the demographic characteristics, clinical presentation, and outcomes of our multicenter cohort adult KTx recipients with COVID-19. Methods conducted a multicenter, retrospective study using data patients hospitalized for COVID-19 collected from 34 centers in Turkey. Demographic findings, laboratory parameters (hemogram, CRP, AST, ALT, LDH, ferritin) at admission follow-up, treatment strategies were reviewed. Predictors poor analyzed. The primary...

10.1186/s12882-021-02299-w article EN cc-by BMC Nephrology 2021-03-19

Endothelial dysfunction (ED) is a key event in the development of atherosclerotic cardiovascular disease (CVD) patients with chronic kidney (CKD). Association hyperuricemia CVD has been previously reported nonuremic population. In this prospective study, we aimed to evaluate effects treatment allopurinol on ED and changes serum reactive oxygen species CKD.In 19 (13 male) hyperuricemic (UA > 7 mg/dl) nondiabetic CKD without any comorbidity, aged < 60 years creatinine clearance (CrCl) between...

10.5414/cn107352 article EN Clinical Nephrology 2011-12-16

Abdominal compartment syndrome (ACS) is a severe clinical condition caused by in-tra-abdominal hypertension (IAH), often observed in surgical and trauma patients. However, ACS can also develop non-surgical patients with massive ascites, leading to acute kidney injury (AKI) due renal hypoperfusion. This study investigates the association between intra-abdominal pressure (IAP) changes, biomarkers, mortality ACS-related AKI. A prospective cohort was conducted on 24 hospitalized asci-tes...

10.20944/preprints202502.0315.v1 preprint EN 2025-02-05

Background and Objectives: Abdominal compartment syndrome (ACS) is a severe clinical condition caused by intra-abdominal hypertension (IAH), often observed in surgical trauma patients. However, ACS can also develop non-surgical patients with massive ascites, leading to acute kidney injury (AKI) due renal hypoperfusion. This study investigates the association between pressure (IAP) changes, biomarkers, mortality ACS-related AKI. Materials Methods: A prospective cohort was conducted on 24...

10.3390/medicina61030383 article EN cc-by Medicina 2025-02-22

<title>Abstract</title> Background The devastating earthquakes in Kahramanmaraş, Türkiye, February 2024, caused extensive trauma and loss of lives, causing unique challenges the management earthquake-related crush syndrome. current study investigates prognostic value pre-earthquake kidney function for mortality prediction patients diagnosed with Methods A multi-center retrospective analysis was performed using data from 469 treated at 46 nephrology clinics. Pre-earthquake Kidney function,...

10.21203/rs.3.rs-5989283/v1 preprint EN Research Square (Research Square) 2025-04-03

More frequent and/or longer hemodialysis (HD) has been associated with improvements in numerous clinical outcomes patients on dialysis. Home HD (HHD), which allows more dialysis lower cost and flexibility treatment planning, is not widely used worldwide. Although, retrospective studies have indicated better survival HHD, this issue remains controversial. In multicenter study, we compared thrice-weekly extended HHD in-center conventional (ICHD) a large patient population long-term...

10.1016/j.ekir.2023.09.007 article EN cc-by Kidney International Reports 2023-09-15

Hemodialysis (HD) patients have increased risk for short-term adverse outcomes of COVID-19. However, complications and survival at the post-COVID-19 period not been published extensively.We conducted a national, multicenter observational study that included adult maintenance HD recovered from confirmed A control group without COVID-19 was selected in same center. We investigated characteristics follow-up compare them with non-COVID-19 group.A total 1223 (635 group, 588 group) 47 centers were...

10.1016/j.ekir.2022.03.017 article EN cc-by-nc-nd Kidney International Reports 2022-03-25

The effect of pre-transplant dialysis modality on early graft function is a matter debate. Although some authors deny the existence significant influence, others suggest that peritoneal (PD) affects favorably, possibly by contributing to more physiologic water balance. In present study, we evaluated influence and late function.We studied 745 patients who underwent first renal transplantation during 1983-2006, comparing records 44 PD [26 male; mean age: 26 +/- 9 years (range: 8-56 years)]...

10.1177/089686080902902s23 article EN Peritoneal Dialysis International 2009-02-01

Hemodialysis patients have extremely increased cardiovascular mortality. Vascular calcification, inflammation, and low serum fetuin-A levels are implicated for In this study, relationship between coronary artery were investigated. Seventy-eight hemodialysis (38 male, 40 female, mean age: 52±14.5 years) included. All on dialysis more than 6 months. Coronary calcium scores (CACS) determined by electron-beam computed tomography. Serum CRP, IL-1β, IL-6, TNF-α, measured. Mean CACS value was...

10.4103/0971-4065.82128 article EN Indian Journal of Nephrology 2011-01-01

Abstract Background Patients with chronic HCV infection have increased liver iron. Recently identified protein hepcidin synthesized in the liver, is thought to be a key regulator for iron homeostasis and induced by inflammation. Lower erythropoietin supplementation requirements were previously reported HD patients infection. We investigated association of prohepcidin inflammation parameters without Methods Sixty (27 male, 33 female, mean age 50 ±15 years) on included. Parameters related...

10.1186/1471-2369-13-56 article EN cc-by BMC Nephrology 2012-07-07

Objective Older adults with co-morbidities have been reported to be at higher risk for adverse outcomes of coronavirus disease 2019 (COVID-19). The characteristics COVID-19 in older patients and its clinical different kidney groups are not well known. Methods Data were retrieved from a national multicentric database supported by Turkish Society Nephrology, which consists retrospectively collected data between 17 April 2020 31 December 2020. Hospitalised aged 18 years or confirmed diagnosis...

10.1111/ijcp.14428 article EN International Journal of Clinical Practice 2021-06-04

The survival of patients returning to hemodialysis (HD) following kidney transplant failure is unfavorable. However, the factors responsible for this poor outcome are largely unknown; chronic inflammation due failed allograft and malnutrition may contribute morbidity mortality. We aimed compare nutritional status its relation with in on HD without previous transplantation.Forty-three renal allografts (27 males; mean age 36±9 yr) 40 never transplanted (24 39±9 were included study. Body...

10.1111/j.1399-0012.2009.01097.x article EN Clinical Transplantation 2009-09-25

Hospital-acquired acute kidney injury (HA-AKI) may commonly develop in Covid-19 patients and is expected to have higher mortality. There little comparative data investigating the effect of HA-AKI on mortality chronic disease (CKD) a control group general population suffering from Covid-19.HA-AKI development was assessed stage 3–5 CKD without among adult hospitalized for Covid-19. The role AKI outcome (in-hospital admission intensive care unit [ICU]) with compared.Among 621 (age 60 [IQR:...

10.3906/sag-2011-169 article EN other-oa TURKISH JOURNAL OF MEDICAL SCIENCES 2021-02-22

Cardiovascular (CV) disease is the main cause of death in peritoneal dialysis (PD) patients, and endothelial dysfunction (ED) an early sign vascular pathology. Ghrelin, a gastric peptide with CV actions, has been shown to inhibit proatherogenic changes experimental models. However, another hormone, leptin, may mediate deleterious effects on system. The aim this study evaluate relationship between plasma ghrelin leptin levels, their association coronary microvascular functions PD patients....

10.3109/08860220903151419 article EN Renal Failure 2009-10-01

Background: Coronavirus disease 2019 (COVID-19) is a systemic which causes an increased inclination to thrombosis by leading coagulation system activation and endothelial dysfunction. Our objective in this study determine whether ischemia-modified albumin (IMA) can be used as new marker patients with COVID-19 for evaluating the risk, pneumonic infiltration, thus, prognosis. Methods: included 59 compatible infiltration on lung computed tomography (CT) who applied were hospitalized Internal...

10.3390/jcm12134304 article EN Journal of Clinical Medicine 2023-06-27

Caliskan Y, Gorgulu N, Yelken B, Akturk F, Yazici H, Turkmen A, Sever MS. Serum uric acid level is associated with cardiac hypertrophy in renal transplant recipients. Clin Transplant 2011: 25: 368–374. © 2010 John Wiley &amp; Sons A/S. Abstract: Background: (UA) as a significant and independent risk factor for cardiovascular disease, the link between this marker left ventricular (LVH) recipients remains to be clarified. Methods: A total of 141 (83 men), ages 18 69 (mean age 37 ± 11), were...

10.1111/j.1399-0012.2010.01244.x article EN Clinical Transplantation 2010-06-28

Endothelial dysfunction (ED) is a common precursor and denominator of cardiovascular events including development atherosclerosis. In this cross-sectional study, we aimed to investigate ED, measured by coronary flow reserve (CFR) in hemodialysis (nHD) patients who were never transplanted with failed renal transplants restarting (fTx-HD).Forty nHD (24 males, mean age 39 ± 9 yr) 43 fTx-HD (27 36 included the study. Clinical biochemical parameters, high-sensitive C-reactive protein (hs-CRP)...

10.1111/j.1399-0012.2009.01160.x article EN Clinical Transplantation 2009-11-18
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