A5082693014- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Renal Diseases and Glomerulopathies
- Vasculitis and related conditions
- Renal Transplantation Outcomes and Treatments
- Cardiovascular Health and Disease Prevention
- Complement system in diseases
- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
- Genetic and Kidney Cyst Diseases
- Neurological Complications and Syndromes
- Blood Pressure and Hypertension Studies
- Atherosclerosis and Cardiovascular Diseases
- Cardiac Imaging and Diagnostics
- Hemodynamic Monitoring and Therapy
- Renal and Vascular Pathologies
- Dermatological and Skeletal Disorders
- Herpesvirus Infections and Treatments
- HIV/AIDS Research and Interventions
- Dermatologic Treatments and Research
- Insurance, Mortality, Demography, Risk Management
- Thermoregulation and physiological responses
- Adolescent and Pediatric Healthcare
- Abdominal vascular conditions and treatments
Istanbul University
2007-2023
Istanbul Aydın University
2019-2023
Istanbul Memorial Hospital
2020-2021
Istanbul Eye Hospital
2020
Istinye University
2020
Bakırköy Dr.Sadi Konuk Eğitim ve Araştırma Hastanesi
2017
Haseki Eğitim ve Araştırma Hastanesi
2016
Kırklareli University
2016
Sağlık Bilimleri Üniversitesi
2016
Center for Rheumatology
2013
Abstract Background Chronic kidney disease (CKD) and immunosuppression, such as in renal transplantation (RT), stand one of the established potential risk factors for severe coronavirus 2019 (COVID-19). Case morbidity mortality rates any type infection have always been much higher CKD, haemodialysis (HD) RT patients than general population. A large study comparing COVID-19 outcome moderate to advanced CKD (Stages 3–5), HD with a control group is still lacking. Methods We conducted...
Abstract Background We aimed to present the demographic characteristics, clinical presentation, and outcomes of our multicenter cohort adult KTx recipients with COVID-19. Methods conducted a multicenter, retrospective study using data patients hospitalized for COVID-19 collected from 34 centers in Turkey. Demographic findings, laboratory parameters (hemogram, CRP, AST, ALT, LDH, ferritin) at admission follow-up, treatment strategies were reviewed. Predictors poor analyzed. The primary...
We investigated the relationship among serum cardiac biomarkers including N-terminal pro-brain natriuretic peptide (NT-pro-BNP), troponin T (cTnT), uric acid and high-sensitive C-reactive protein (hs-CRP) noninvasive predictors of atherosclerosis carotid intima-media thickness (IMT), aortic stiffness (pulse wave velocity (PWV)) transthoracic coronary flow reserve (CFR) in peritoneal dialysis (PD) patients.37 PD patients were included study. measured (1) IMT, (2) PWV augmentation index (AIx),...
Abstract Background A better understanding of innate and adaptive cells in COVID‐19 is necessary for the development effective treatment methods vaccines. Methods We studied phenotypic features immune cells, oxidative burst, phagocytosis, apoptosis. One hundred three patients with were grouped according to their clinical into categories mild (35%), moderate (40.8%), severe (24.3%). Results Monocytes CD16 + pro‐inflammatory monocytes tended shed HLA‐DR, especially cases ( p < 0.01)....
Thalidomide is successfully used in the treatment of multiple myeloma, leprosy and various autoimmune diseases due to its anti-angiogenic, immunomodulatory anti-inflammatory effects. Thalidomide's most common side effects are constipation, neuropathy, fatigue, sedation, rash, tremor peripheral edema. We achieved complete response with a 400 mg/day dose thalidomide therapy 58-year-old male patient diagnosed relapsing refractory myeloma. While continuing for sustainable response, was...
Behçet’s disease is an inflammatory of unknown etiology which involves recurring oral and genital aphthous ulcers ocular lesions as well articular, vascular, nervous system involvement. Focal segmental glomerulosclerosis (FSGS) usually seen in viral infections, immune deficiency syndrome, sickle cell anemia, hyperfiltration secondary to interferon therapy. Here, we present a case FSGS identified with kidney biopsy patient who had been diagnosed received interferon-alpha treatment for uveitis...
Cardiovascular problems are a major cause of morbidity and mortality in patients with autosomal dominant polycystic kidney disease (ADPKD).The aim this study was to investigate coronary flow velocity reserve (CFVR) as marker endothelial dysfunction, carotid intima media thickness (CIMT) subclinical organ damage insulin resistance (IR) cardiovascular risk factor ADPKD.Twenty-two normotensive ADPKD well-preserved renal function 19 healthy subjects were included the study. Creatinine clearances...
Secondary hyperparathyroidism may manifest as hypercalcemia in the post-transplant period. The classical treatment method is parathyroidectomy and alternative oral cinacalcet, a calcimimetic agent therapy. We retrospectively investigated effect of cinacalcet therapy on kidney patient survival these patients.In our single-center, retrospective, observational study, files 934 patients who underwent renal transplantation unit between 2008 2022 were reviewed. A total 23 started for (calcium >...
Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary and extrarenal manifestations may be observed in many organ systems. Hypothalamus-pituitary-adrenal axis was not evaluated extensively patients with ADPKD. We aimed to evaluate this these patients.Twenty two ADPKD 27 healthy subjects were enrolled. Basal dehydroepiandrosterone sulfate (DHEAS) levels cortisol DHEA responses low dose short adrenocorticotropin stimulation test assessed. Correlation analyses of...
Background: Arterial stiffness is a strong predictor of mortality in hemodialysis patients. In this study, we aimed to investigate possible relations arterial with volume status determined by bioimpedance analysis and aortic blood pressure parameters. Also, effects single session on these parameters were studied. Methods: A total 75 patients (M/F: 43/32; mean age: 53 ± 17) enrolled. Carotid-femoral pulse wave velocity, augmentation index, measured applanation tonometry before after...
A better understanding of the innate and adaptive cells in COVID-19 disease caused by SARS-CoV-2 coronavirus is a necessity for development effective treatment methods vaccines. We studied phenotypic features immune cells, oxidative burst, phagocytosis apoptosis. One hundred three patients with grouped according to their clinical as mild (35%), moderate (40.8%), severe (24.3%) were included study. Monocytes from all CD16+ pro-inflammatory monocytes. Neutrophils mature functional. No defect...
dehidrogenaz (LDH) düzeyleri,
Summary Paroxysmal nocturnal hemoglobinuria (PNH) is a rare disorder characterized by intravascular hemolysis, hemoglobinuria, and thrombosis. Thrombotic attacks are life threatening responsible for nearly 50% of PNH‐related deaths. Compared with thrombotic events, bleeding related to thrombocytopenia in PNH quite rare. This report describes an atypical clinical presentation problems the diagnosis management woman who presented splenic infarct followed massive intra‐abdominal due rupture....
SUMMARY A better understanding of the innate and adaptive cells in COVID-19 disease caused by SARS-CoV-2 coronavirus is a necessity for development effective treatment methods vaccines. We studied phenotypic features immune cells, oxidative burst, phagocytosis apoptosis. One hundred three patients with grouped according to their clinical as mild (35%), moderate (40.8%), severe (24.3%) were included study. Monocytes from all CD16 + pro-inflammatory monocytes. Neutrophils mature functional. No...
An outbreak of a novel respiratory disease due to coronavirus species was emerged in 2019 and named as Coronavirus Disease-2019 (COVID-19). Clinical immunological factors affecting the course COVID-19 kidney transplant recipients (KTR) are not well-known. In this prospective observational study, we presented 20 KTR with pnemonia examined predicting severity COVID-19. A total 10 without used control group. Lymphocyte subsets were determined by flow cytometry. 13/20 patients, immunophenotyping...
Caliskan, Y.; Alpay, N.; Akagun, T.; Toz, B.; Kara, E.; Tufan, F.; Guz, G.; Polat, Oflaz, H.; Turkmen, A.; Sever, M. S. Author Information
Amaç: Valgansiklovir böbrek nakli hastalarında Sitomegalovirüs (CMV) profilaksisi için tercih edilen ilaçtır.Standart dozun (900 mg/gün) fonksiyonlarına olan olumsuz etkisi ve lökopeni yan nedeniyle düşük
Erişkin Böbrek Nakli Hastalarında Uzun Etkili Takrolimus Kullanımı, Dönem Ve Hasta Sağkalımı Üzerine Etkisi, Tek Merkez Deneyimi
 AMAÇ : organ nakli hastalarında kullanılan en önemli immun supresif ajanlardan biridir. etkili takrolimus preparatının polifarmasiyi azaltması ve kan düzeyini daha stabil tuttuğuna dair bilgiler bulunmaktadır. Biz de ünitemizde uzun takrolimusa geçilen az 1 yıl takip edilen böbrek renal fonksiyon değişimi hasta sürvisine etkisini araştırmayı amaçladık. 
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