Necmi Eren
A5003132118- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Platelet Disorders and Treatments
- COVID-19 and healthcare impacts
- Systemic Sclerosis and Related Diseases
- COVID-19 Clinical Research Studies
- Vasculitis and related conditions
- Genetic and Kidney Cyst Diseases
- Blood groups and transfusion
- Autoimmune Bullous Skin Diseases
- Systemic Lupus Erythematosus Research
- Hemoglobinopathies and Related Disorders
- Cardiovascular Health and Disease Prevention
- Liver Disease Diagnosis and Treatment
- Renal and Vascular Pathologies
- Cardiovascular Disease and Adiposity
- Diet and metabolism studies
- Genetic Syndromes and Imprinting
- Blood Pressure and Hypertension Studies
- Peripheral Artery Disease Management
- Hepatitis B Virus Studies
- Complement system in diseases
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Lysosomal Storage Disorders Research
Kocaeli Üniversitesi
2015-2024
Canakkale Onsekiz Mart Universitesi Tip Fakultesi Hastanesi
2021
Sağlık Bilimleri Üniversitesi
2020
Selçuk Üniversitesi Tıp Fakültesi Hastanesi
2020
Adıyaman University
2013
Karadeniz Technical University
2004
Abstract Background Chronic kidney disease (CKD) and immunosuppression, such as in renal transplantation (RT), stand one of the established potential risk factors for severe coronavirus 2019 (COVID-19). Case morbidity mortality rates any type infection have always been much higher CKD, haemodialysis (HD) RT patients than general population. A large study comparing COVID-19 outcome moderate to advanced CKD (Stages 3–5), HD with a control group is still lacking. Methods We conducted...
The therapeutic potential of a novel, targeted-release formulation oral budesonide (Nefecon) for the treatment IgA nephropathy (IgAN) was first demonstrated by phase 2b NEFIGAN trial. To verify these findings, 3 NefigArd trial tested efficacy and safety nine months with Nefecon (16 mg/d) versus placebo in adult patients primary IgAN at risk progressing to kidney failure (ClinicalTrials.gov: NCT03643965). NefIgArd multicenter, randomized, double-blind, placebo-controlled two-part In Part A,...
Atacicept is a first-in-class, dual anti-B-cell Activation Factor–A Proliferation-Inducing Ligand fusion protein in clinical evaluation for treatment of IgA nephropathy. To compare efficacy and safety atacicept versus placebo patients with IgAN, this randomized, double-blind, placebo-controlled phase 2b trial ORIGIN enrolled 116 individuals biopsy-proven Participants were randomized to 150, 75, or 25 mg once weekly up 36 weeks. Primary key secondary endpoints changes urine creatinine ratio...
Abstract In 2002 and 2003, a total of 19 persons in Turkey had suspected cases Crimean-Congo hemorrhagic fever (CCHF) or similar viral infection. Six serum samples were tested; all six found positive for immunoglobulin M antibodies against CCHF virus. Two the yielded virus isolates. Genetic analysis isolates showed them to be closely related from former Yugoslavia southwestern Russia. These are first reported Turkey. Eighteen patients handled livestock, one was nurse with probable nosocomial...
Abstract Background Maintenance hemodialysis (MHD) patients are at increased risk for coronavirus disease 2019 (COVID-19). The aim of this study was to describe clinical, laboratory, and radiologic characteristics determinants mortality in a large group MHD hospitalized COVID-19. Methods This multicenter, retrospective, observational collected data from 47 nephrology clinics Turkey. Baseline laboratory radiological characteristics, COVID-19 treatments during hospitalization, need intensive...
Key Points Participants who completed a 36-week double-blind study of atacicept were eligible for 60-week, open-label extension study. Atacicept 96-week treatment resulted in sustained reductions galactose-deficient IgA1, hematuria, and urine protein-creatinine ratio. The slope the eGFR was similar to that observed general population without kidney disease. Background B-cell activating factor (BAFF) A proliferation-inducing ligand (APRIL) play key roles pathogenesis IgA nephropathy. is novel...
Hemodialysis (HD) patients have increased risk for short-term adverse outcomes of COVID-19. However, complications and survival at the post-COVID-19 period not been published extensively.We conducted a national, multicenter observational study that included adult maintenance HD recovered from confirmed A control group without COVID-19 was selected in same center. We investigated characteristics follow-up compare them with non-COVID-19 group.A total 1223 (635 group, 588 group) 47 centers were...
Abstract Background The largest data on the epidemiology of primary glomerular diseases (PGDs) are obtained from databases countries or centers. Here, we present extended results Primary Glomerular Diseases Study Turkish Society Nephrology (TSN-GOLD) Working Group. Methods Data patients who underwent renal biopsy and received diagnosis PGD were recorded in database prepared for study. A total 4399 47 centers evaluated between May 2009 2019. at time kidney analyzed. After exclusion without...
Abstract The data regarding primary FSGS (pFSGS) from different parts of the world differ. While prevalence pFSGS has been increasing in Western countries like USA, it follows an inconsistent trend Europe and Asia a decreasing Far Eastern such as China last two decades. There are undetermined factors to explain those national geographic discrepancies. Herein, we aimed reveal current with clinical histopathological characteristics Turkish adults. This study includes biopsy-proven patients...
Aim Hemodialysis ( HD ) patients had higher cardiovascular mortality and it is related to atherosclerosis. Epicardial adipose tissue EAT thickness a marker of atherosclerosis independent predictor coronary artery disease. The aim our study was evaluate the relationship between carotid intima‐media CIMT predictors early in patients. Methods included 62 40 healthy controls. were measured by echocardiography all subjects. Results (6.98 ± 1.67 vs. 3.84 0.73 mm, P < 0.001, 0.94 0.17 0.63 0.11...
Objectives Anemia is highly prevalent in chronic kidney disease patients; however, its identification and management have been reported to be suboptimal. In this study we aimed describe the prevalence, severity, risk factors, treatment of anemia different nephrology centers, among patients who were not given renal replacement therapy. Materials methods We performed a multicenter cross-sectional three clinics. Adult (>18 years age) with an estimated glomerular filtration rate (eGFR) below 60...
<b><i>Background:</i></b> Fabry disease (FD) is an X-linked lysosomal storage disorder resulting from lack of alpha-galactosidase A (AGALA) activity in lysosomes. <b><i>Objective:</i></b> In this multicenter study, we aimed to evaluate the prevalence FD renal transplant (Tx) recipients Turkey. We also screened dialysis patients as a control group. <b><i>Methods:</i></b> All Tx and were regardless presence primary...
Objective Older adults with co-morbidities have been reported to be at higher risk for adverse outcomes of coronavirus disease 2019 (COVID-19). The characteristics COVID-19 in older patients and its clinical different kidney groups are not well known. Methods Data were retrieved from a national multicentric database supported by Turkish Society Nephrology, which consists retrospectively collected data between 17 April 2020 31 December 2020. Hospitalised aged 18 years or confirmed diagnosis...
<b><i>Introduction:</i></b> There are many differences between hemodialysis (HD) and peritoneal dialysis (PD) treatments, including their impact on the psychological status of patients. In this study, our aim was to compare statuses HD PD patients during social isolation period due COVID-19 pandemic. <b><i>Methods:</i></b> We conducted cross-sectional study adult when curfew measures were in effect. used an electronic form composed 3 sections...
<b><i>Background/Aims: </i></b>Contrast induced nephropathy (CIN) has multifactorial etiopatogenesis including oxidative stress and vasoconstriction. Nebivolol is an antioxidant vasodilatatory effect via NO release may prevent CIN development. We have noticed that a few number of studies evaluated the effectiveness nebivolol for prevention used serum creatinine (sCr) levels detection. However, sCr insensitive marker renal damage. Therefore in this study we...
Aims The prevention of acute kidney injury can be lifesaving for the intensive care unit patients. However, conventional methods are not sufficient prediction risk future injury. In this study, promising biomarker, neutrophil gelatinase-associated lipocalin, was compared with cystatin C as an indicator Methods One hundred and eighty-three adult patients without chronic disease or renal replacement therapy were included in study. plasma urine concentrations lipocalin assessed on second day...
Background: Tumor lysis syndrome (TLS) is a potentially fatal complication of cancer therapy characterized by severe electrolyte and metabolic abnormalities such as hyperphosphatemia, hyperkalemia, hypocalcaemia. TLS usually occurs in aggressive hematologic malignancies Burkitt lymphoma acute leukemia. has rarely been observed multiple myeloma (MM). Case report: We present 2 patients with relapsed MM who developed after the first cycle carfilzomib treatment. Conclusion: Carfilzomib...