A5009410270- Acute Myeloid Leukemia Research
- Multiple Myeloma Research and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Protein Degradation and Inhibitors
- Cancer Treatment and Pharmacology
- Hemoglobinopathies and Related Disorders
- Pharmacological Effects and Toxicity Studies
- Erythropoietin and Anemia Treatment
- Peptidase Inhibition and Analysis
- Blood disorders and treatments
- Complement system in diseases
- Acute Lymphoblastic Leukemia research
- Fungal Infections and Studies
- Urticaria and Related Conditions
- Hematopoietic Stem Cell Transplantation
- Autoimmune Bullous Skin Diseases
- Blood properties and coagulation
- S100 Proteins and Annexins
- Blood groups and transfusion
- Platelet Disorders and Treatments
- GDF15 and Related Biomarkers
- Chronic Myeloid Leukemia Treatments
- Advanced Glycation End Products research
Kocaeli Üniversitesi
2015-2024
Bolu Abant İzzet Baysal University
2021
Sağlık Bilimleri Üniversitesi
2020-2021
TUBITAK BILGEM
2020
Marmara University
2017
Muğla University
2017
Sir Ganga Ram Hospital
2017
Mardin Artuklu University
2016
Eskişehir Osmangazi Üniversitesi Tıp Fakültesi Hastanesi
2015
Bursa Uludağ Üni̇versi̇tesi̇
2015
Immune thrombocytopenia (ITP) is an autoimmune disease characterized by dysregulation of T cells. Programmed death (PD) 1 and programmed ligand (PD-L1) are cosignaling molecules, the major role PD-1 pathway inhibition self-reactive cells to protect against diseases. We measured levels serum soluble PD (sPD-1) PD-L1 (sPD-L1) in 67 patients with ITP (24 newly diagnosed [ndITP], 43 chronic [cITP]) 21 healthy controls (HCs). determined decreased sPD-1 both ndITP cITP when compared HC. Moreover,...
The involvement of the ovary in lymphomatous process is rare. Such an may occur 2 ways, primary or secondary. We report 5 cases ovarian non-Hodgkin's lymphoma, with 3 which primarily arising ovaries. Ovarian lymphoma can mimic more frequently occurring tumors including advanced epithelial carcinoma and radical surgery be performed instead a biopsy. immunophenotypic clinicopathologic features exhibited this small series are described to call attention early diagnosis treatment lymphoma. All...
Abstract Objectives Hepcidin plays a regulatory role in systemic iron homeostasis. GDF ‐15 has been found to be expressed from matured erythroblasts and very high levels of suppresses hepcidin secretion. In this study, we evaluated polycythemia vera ( PV ) essential thrombocythemia ET ). Methods The study included 29 patients 21 healthy controls. patient group 13 with 16 . Serum were measured at the time diagnosis, before initiation any therapy. Results did not differ significantly chronic...
Abstract Introduction Hodgkin lymphoma (HL) is unusual among malignancies, with inflammation playing such a prominent role in its pathogenesis. S100A8/A9 (calprotectin) heterodimeric protein, which has the inflammatory response and oncogenesis. In this study HL patients, correlation between serum levels treatment responses was investigated along whether marker correlated other markers. Materials Methods Thirty‐three patients 20 healthy volunteers were included. Demographic clinical...
In this study, we aimed to obtain real-life data on the use of antimyeloma agents, which significantly increase overall survival (OS) in multiple myeloma (MM) patients, primary plasma cell leukemia (pPCL) patients with a poor prognosis.
GDF15, hepcidin and mitoferrin-1 (mfrn-1) are proteins involved in systemic iron regulation. There no studies the literature demonstrating serum mfrn-1 levels polycythemia vera (PV) essential thrombocythemia (ET) patients. The aim of this study was to investigate PV ET patients.Materials methods: Ten PV, 17 patients, 27 healthy controls (HCs) were enrolled. values measured with enzyme-linked immunosorbent assay (ELISA).Results: GDF15 higher myeloproliferative neoplasm (MPN) group (P =...
Two-thirds of newly diagnosed patients with multiple myeloma (MM) are over 65 yr and/or physically unfit. Such not eligible for high-dose chemotherapy or stem cell transplantation. The treatment aims in these should be to prolong survival by obtaining the best possible response, while maintaining good tolerability. aim our study was evaluate response and treatment-related toxicities treated conventional novel protocols.The records 138 elderly (≥65 yr) MM were retrospectively evaluated.The...
Background: Tumor lysis syndrome (TLS) is a potentially fatal complication of cancer therapy characterized by severe electrolyte and metabolic abnormalities such as hyperphosphatemia, hyperkalemia, hypocalcaemia. TLS usually occurs in aggressive hematologic malignancies Burkitt lymphoma acute leukemia. has rarely been observed multiple myeloma (MM). Case report: We present 2 patients with relapsed MM who developed after the first cycle carfilzomib treatment. Conclusion: Carfilzomib...
Perinephric abscess is a rare complication of urinary tract infections, and the etiology usually gram negative bacillus. We report case Candida glabrata perinephric in patient with diabetes mellitus who had recent episode pyelonephritis that was treated antibiotics. Percutaneous drainage fluconazole treatment led to resolution infection. Yeast should be considered when symptoms acute or chronic infection occur elderly diabetic patients, especially patients are unresponsive antibacterial...
Anticonvulsant hypersensitivity syndrome is a fatal, idiosyncratic drug reaction that caused by aromatic antiepileptic drugs. This cutaneous also called pseudolymphoma because of its clinical and histological similarities with malignant lymphoma. The primary findings are fever, skin rashes, enlarged lymph nodes, single or multiple internal organ involvement hematological abnormalities. Typically, anticonvulsant occurs 1-8 weeks after administration. We herein present the case patient who had...
Calprotectin (CLP), S100A6, and high mobility group nucleosome-binding protein 1 (HMGN1), known as alarmins, are involved in the pathogenesis of many tumors. In this study, we aimed to investigate relationships serum CLP, HMGN1 levels with clinical laboratory findings patients multiple myeloma (MM) their roles MM.
Objective: This study aimed to evaluate patients with RRMM who underwent daratumumab (DARA) therapy.Materials and Methods: multicenter retrospective included 134 at least two courses of DARA from February 01, 2018 April 15, 2022.Epidemiologic, disease treatment characteristics and, related side effects were evaluated.Survival analysis performed.Results: The median age initiation therapy was 60 (35-88) years.The time the follow-up 41.2 (5.1-223) 5.7 (2.1-24.1)months, respectively.The ORR...