A5063078068- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Kruppel-like factors research
- Acute Myeloid Leukemia Research
- Palliative Care and End-of-Life Issues
- CNS Lymphoma Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Platelet Disorders and Treatments
- Acute Lymphoblastic Leukemia research
- Lymphoma Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Eosinophilic Disorders and Syndromes
- Blood disorders and treatments
- Bone and Joint Diseases
- Neutropenia and Cancer Infections
- Pneumocystis jirovecii pneumonia detection and treatment
- Sepsis Diagnosis and Treatment
- Hematological disorders and diagnostics
- Cancer Risks and Factors
- Multiple Myeloma Research and Treatments
- Systemic Sclerosis and Related Diseases
- Hematopoietic Stem Cell Transplantation
- Brain Metastases and Treatment
Istanbul Medipol University
2016-2024
Istanbul University
2013-2019
The JAK2V617F mutation is present in the majority of patients with essential thrombocythemia (ET) and primary myelofibrosis (PMF). impact this on disease phenotype ET PMF still a matter discussion. This study aims to determine whether there are differences clinical presentation outcome between without mutation.In single-center study, total 184 consecutive Philadelphia-negative chronic myeloproliferative neoplasms, 107 cases 77 PMF, were genotyped for using JAK2 Ipsogen MutaScreen assay,...
Background: Although the outcome of patients admitted to ICUs have considerably improved in recent years, HSCT continues be significantly associated with mortality. Purpose: The aim study was examine prognostic factors ICU mortality after HSCT. Acute Physiological and Chronic Health Evaluation II (APACHE II) used as a scoring system. Methods: Within scope research, clinical laboratory data 52 who were undergoing between 2013 2019 analyzed retrospectively. Results: Mortality risk found 4.22...
<p class="ql-align-justify">Chronic myeloproliferative neoplasms (MPNs) are clonal disorders of hematopoiesis resulting from the transformation a hematopoietic stem cell, with abnormal proliferation one or more myeloid lineages. The Philadelphia-negative (Ph-negative) classical MPNs mainly comprise polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF). identification JAK2V617F mutation in early 2005 followed by discovery JAK2 exon 12 MPL gene mutations, have...
<p class="ql-align-justify">Polycythemia vera (PV) is a myeloproliferative neoplasm characterized by increased red blood cell mass and usually overproduction of granulocytes platelets spleen size. JAK2V617F mutation present in more than 95% PV patients. Bone marrow examination reveals excessive proliferation erythroid, myeloid, megakaryocytic elements. The prognosis depends on the severity complications occurring during clinical course. Thrombotic are main cause morbidity mortality PV....
Primary myelofibrosis (PMF) is a chronic myeloproliferative neoplasm (MPN) characterized by anemia, teardropshaped red cells in blood, leukoerythroblastosis, bone marrow fibrosis, osteosclerosis and extramedullary hematopoiesis. Approximately 50% of PMF patients harbor JAK2V617F mutation MPL mutations are present further 10%. Bone examination reveals hypercellular with atypical megakaryocytes slight fibrosis cellular phase PMF. Diagnosis requires the exclusion other MPN. Most diagnosed...
<p class="ql-align-justify">Essential thrombocythemia (ET), a member of the family myeloproliferative neoplasms (MPN), is characterized by an overproduction platelets and usually accompanied thrombotic or hemorrhagic symptoms. JAK2V617F mutation present in about one-half patients with ET. Mutations MPL exon 10 are further 4% patients, W515L being most common mutation. The diagnosis made exclusion reactive thrombocytosis other myeloid malignancies. Bone marrow examination reveals increase...
Background/Aim: Autologous hematopoietic cell transplantation (AutoHCT), administered at high doses, has improved survival rates among patients with refractory or recurrent lymphoma and multiple myeloma (MM). However, inconsistencies in defining obesity, varying body weight ranges, heterogeneous patient populations have been examined. Some researchers hypothesized that significantly overweight face a higher risk of transplant-related complications. This study investigates the association...
To investigate the risk factors for, and incidence of, structural abnormalities in brain imaging among hematopoetic stem cell transplant (HSCT) patients to correlate these findings with physical examinations.This study retrospectively reviewed all post-HSCT taken researchers' center between 2014 2020.87 of 627 were imaged.34.5% (n = 30) female.Age at ranged from 18 74 years (median: 45).The most common malignancies acute myeloid leukemia (AML; n 21; 24.1%), 51 (58.6%) received allogeneic...
Amaç: Sitomegalovirüs (CMV) reaktivasyonu allojenik hematopoetik kök hücre transplantasyonu sırasında sık görülür.Hepatit B (HBV), akut hepatit ve fulminan karaciğer yetmezliği veya sadece HBV DNA düzeyinde artma şeklinde ortaya çıkabilir.Allojenik nakli bağımsız bir risk faktörüyken, otolog (HKH) alıcıları için nakil sürecine etkileri net bilinmemektedir.Çalışmamızda, geriye dönük olarak analiz etti