A5035484545- Hematopoietic Stem Cell Transplantation
- Lymphoma Diagnosis and Treatment
- Neutropenia and Cancer Infections
- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- Multiple Myeloma Research and Treatments
- Acute Lymphoblastic Leukemia research
- Antifungal resistance and susceptibility
- Chronic Myeloid Leukemia Treatments
- Hemoglobinopathies and Related Disorders
- Fungal Infections and Studies
- Viral-associated cancers and disorders
- CNS Lymphoma Diagnosis and Treatment
- Cytomegalovirus and herpesvirus research
- Pneumocystis jirovecii pneumonia detection and treatment
- Lipoproteins and Cardiovascular Health
- Iron Metabolism and Disorders
- Mesenchymal stem cell research
- Blood groups and transfusion
- Hematological disorders and diagnostics
- Blood disorders and treatments
- Complement system in diseases
- Mycobacterium research and diagnosis
- Herpesvirus Infections and Treatments
- Eosinophilic Disorders and Syndromes
Istanbul Medipol University
2021-2025
Erciyes University
2015-2024
Ankara Yıldırım Beyazıt University
2023-2024
State Hospital
2024
Üsküdar University
2024
King Hamad University Hospital
2024
Memorial Ankara Hospital
2024
Bozok Universitesi
2017-2021
Society of Critical Care Medicine
2021
Vall d'Hebron Institut de Recerca
2018
The efficacy of methotrexate (MTX), a widely used cytotoxic chemotherapeutic agent, is often limited by its severe hepatotoxicity. Regarding the mechanisms these adverse effects, several hypotheses have been put forward, among which oxidative stress noticeable. present study was undertaken to determine whether grape seed extract (GSE), new natural free radical scavenger, could ameliorate MTX-induced injury in rat liver. animals were divided into 3 groups. Each group consisted 12 animals....
Abstract The aim of the study is to review clinical manifestations and hematological findings brucellosis pancytopenia, with or without malignancies. records 202 patients were evaluated retrospectively. Among these cases seen in a 6 year period between April 1999 June 2005, 30 pancytopenia identified. most common manifestation was fever, followed by weight loss, anorexia, malaise, arthralgia, hepatosplenomegaly. Bone marrow biopsies revealed hypercellularity normocellularity. bone evaluation...
Conditioning regimens used during stem cell transplant provide prolonged control or cure of the disease in patients with acute lymphoblastic leukemia (ALL). In this study, we present a comparison treatment results for 95 ALL who underwent allogeneic hematopoietic (AHSCT) total body irradiation plus cyclophosphamide (TBI + Cy) busulfan (Bu as conditioning regimen. Median age was 25 (range: 9-54) years. follow-up 24 3-107) months. overall survival (OS) found to be 29 event-free (EFS) 9 OS 37...
The aim of this study is to assess the factors influencing early mortality (7-day after index blood culture) in haematological malignancy patients with Gram negative bacilli (GNB) bacteraemia.Infection control committee records were reviewed identify cases between March 2006 and June 2011. Only one bacteraemic episode per patient was included study.A total 154 GNB bacteraemia identified. rate 19.5% (30 out 154). Blood cultures revealed Enterobacteriacea 120 (Escherichia coli; 86, Klebsiella...
The use of αβ+ T-cell-depleted grafts is a novel approach to prevent graft failure, graft-versus-host disease (GVHD), and non-relapse mortality (NRM) in patients undergoing haploidentical hematopoietic stem cell transplantation.Thirty-four with acute leukemia lacking match donor were treated αβ allografts from family donors. A total 24 had myeloid (AML) 10 lymphoblastic leukemia. 84.4% the high-risk group, 55.9% not remission. preparative regimen included thiotepa, melphalan, fludarabine,...
The field of immunotherapies including monoclonal antibodies and cellular therapies is rapidly evolving cytokine release syndrome an obstacle to deal with in this process. This a kind toxic condition caused by the pro-inflammatory cytokines released activation extreme immune response. In fact, up some extent, may be indicator antitumor effects immune-based therapies. Therefore, distinction between level at which efficiency treatment ensured point life-threatening starts critically important....
Purpose. Sepsis and septic shock are the major causes of death in intensive care units. This study aimed to evaluate clinical safety efficacy mesenchymal stem cells (MSCs) sepsis patients. Methods. Ten patients were enrolled study. Adipose-derived MSC infusions given (1 × 106/kg, on 1st, 3rd, 5th, 7th, 9th days therapy) together with standard therapy. Before applications, blood samples collected for cytokine assessment (TNF-α, IFN-γ, IL-2, IL-4, IL-6, IL-10). The laboratory improvements...
Microsporidia species are obligate intracellular parasites and constitute one of the most important opportunistic pathogens that can cause severe infections especially in immunocompromised patients. Enterocytozoon bieneusi Encephalitozoon intestinalis common among 14 microsporidia identified as human pathogens. The aim this study was to investigate prevalence E.intestinalis E.bieneusi cancer patients under chemotherapy by immunofluorescent antibody conventional staining methods. A total 123...
Current treatment modalities can cure up to 70–80 % of patients with classical Hodgkin lymphoma. Approximately, 20–30 require further options. Brentuximab vedotin has been approved for the relapsed and refractory In present study, we report experience brentuximab as single agent in 58 or The objective response rate was 63.5 13 complete responders (26.5 %) among 49 evaluated at early phase (2–5 cycles). Upon prolongation (≥6 cycles), 37 achieved a final 32.4 21.6 10.8 partial response....
Iron overload increases the risk of infections, veno-occlusive disease and hepatic dysfunction in post-transplant period. Our objective was to investigate association pre-transplant ferritin levels with complications survival after allogeneic hematopoietic stem cell transplantation (alloHSCT).We retrospectively analysed 84 patients' data who had undergone HSCT into two groups: patients a serum level ≥ 1000 ng/ml, <1000 ng/ml at time HSCT.Cox-regression analysis showed that were significantly...
Summary Saprochaete capitata is a very rare pathogen that causes invasive disease particularly in patients with haematological malignancies. We recognised clustering of S. fungaemia recent years. So, we report our 6‐year surveillance study among malignancies and haematopoietic stem cell transplant. performed retrospective observational study. Hospitalised aged >18 years were included the A total 51 episodes 47 analysed. The characteristics compared to candidemia. Median duration...