A5024920083- Hemoglobinopathies and Related Disorders
- Hemophilia Treatment and Research
- Iron Metabolism and Disorders
- Blood Coagulation and Thrombosis Mechanisms
- Cancer-related gene regulation
- Childhood Cancer Survivors' Quality of Life
- Platelet Disorders and Treatments
- Neutropenia and Cancer Infections
- Acute Lymphoblastic Leukemia research
- Hematological disorders and diagnostics
- Lipoproteins and Cardiovascular Health
- Chronic Myeloid Leukemia Treatments
- Metabolism and Genetic Disorders
- Blood disorders and treatments
- Neonatal Health and Biochemistry
- Acute Myeloid Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Erythrocyte Function and Pathophysiology
- Blood groups and transfusion
- Esophageal and GI Pathology
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Retinoids in leukemia and cellular processes
- Autoimmune and Inflammatory Disorders Research
- Streptococcal Infections and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
İstanbul Kanuni Sultan Süleyman Eğitim ve Araştırma Hastanesi
2012-2024
Sağlık Bilimleri Üniversitesi
2021-2022
University of Health Science
2022
Palmetto Hematology Oncology
2019
Ministry of Health
2015
Bakırköy Psychiatric Hospital
2004-2012
Van Yüzüncü Yıl Üniversitesi
2011
İstanbul Eğitim ve Araştırma Hastanesi
2004
The NOTCH signaling pathway plays important role in the development of multicellular organisms, as it regulates cell proliferation, survival, and differentiation. In adults, is essential for T- or B-lymphocyte lineage commitment. NOTCH1 FBXW7 mutations both lead activation are found majority T-ALL patients. this study, mutation analysis genes was performed 87 pediatric T-ALLs who were treated on ALL-BFM protocols. 19 patients (22%), activating observed either heterodimerization domain PEST 7...
In this study, we aimed to determine serum adrenomedullin levels and compare them with of C-reactive protein (CRP) procalcitonin (PCT). Cancer patients aged 0–18 years who experienced febrile neutropenia attacks were included in the study. Adrenomedullin, CRP, PCT analyzed at admission, day 3, days 7–10 later. Fifty episodes that developed 37 The mean age was 7.5 ± 4.7 (1–18) years. had leukemia (73%), solid tumors (19%), lymphoma (8%). percentages clinically documented infection (CDI),...
The NOTCH signaling pathway plays important role in the development of multicellular organisms, as it regulates cell proliferation, survival, and differentiation. In adults, is essential for T- or B-lymphocyte lineage commitment. NOTCH1 FBXW7 mutations both lead activation are found majority T-ALL patients. this study, mutation analysis genes was performed 87 pediatric T-ALLs who were treated on ALL-BFM protocols. 19 patients (22%), activating observed either heterodimerization domain PEST 7...
Long used in established industrialized nations to treat patients with haemophilia and inhibitors, factor eight inhibitor bypassing activity (FEIBA) has, recent years, been introduced into more geographically diverse settings. Data are needed on how successfully FEIBA therapy has implemented new regions. To determine the efficacy safety of for treatment acute bleeding surgical haemostasis a newly country. A multicentre registry inhibitors receiving was Turkey. With standardized case report...
Most common causes of microcytic anemia in children are iron deficiency (IDA) and thalassemia. Differentiation these detection coexistence is essential for genetic counseling to set a treatment plan. Aim characterize the frequency IDA thalassemia trait (TT) presenting with hypochromic, define significance blood count parameters differential diagnosis. Of 200 enrolled, 107 were male (53.5%). In total 154 had (77%), 27 β-TT (13.5%), 11 (5.5%) both conditions coexisted. Eight patients...
Hemofili A'lı 270 Olgunun Faktör 8 Gen Mutasyon Spektrumu: 36 Yeni Tespiti Amaç: A (HA), faktör (F8) genindeki hemizigot mutasyonların neden olduğu X'e bağlı kalıtsal kanama bozukluğudur.Bu çalışmanın amacı, Türkiye'den büyük bir HA kohortunda F8 geninin mutasyon spektrumunu belirlemek ve fenotip-genotip
Congenital factor VII deficiency is the most common form of rare coagulation deficiencies. This article presents a retrospective evaluation 73 cases that had been followed at our center. The study consisted 48 males and 25 females (2 months-19 years). Thirty-one (42.5%) them were asymptomatic. Out symptomatic patients, 17 severe clinical symptoms, whereas 8 presented with moderate mild symptoms. symptoms listed in order frequency as follows: epistaxis, petechia or ecchymose, easy bruising,...
The present study was designed to evaluate the significance of echocardiography versus cardiac troponin I levels in early detection anthracycline dependent cardiotoxicity acute lymphoblastic leukemia (ALL) patients. A total 276 pediatric ALL patients were included prospectively along 3 phases data collection lasted from 2002 2009; including phase (March February 2003; n = 25; 53.3% females), II (September 2003 April 2004; 35; 57.1% and III (January 2005 June 216; 52.7% females) with respect...
Achromobacter xylosoxidans is an aerobic gram-negative bacillus and important cause of bacteremia in immunocompromised patients. We describe a leukemia pediatric patient with severe neutropenia who developed A resistant to multiple antibiotics, treated the tigecycline piperacillin-tazobactam addition supportive medications.
The aim of the study was to evaluate cardiac function and early dysfunction patients followed as thalassemia major. In this study, authors compared 100 patients, diagnosed major with mean age 11.84 ± 4.35, 60 healthy control subjects at same between 2008 2011. Early diagnosis iron overload that may occur after repeated transfusions is important in patient group. To detect accumulation, ferritin echo findings, 24-hour Holter, magnetic resonance imaging (MRI) T2* values sex, treated chelators,...
Abstract Objectives To evaluate the long‐term efficacy and safety of deferasirox therapy in a large observational cohort children with transfusion‐dependent thalassemia (TDT) sickle cell anemia (SCA) Turkey. Methods This was multicenter, prospective study including TDT SCA patients aged 2‐18 years iron overload (≥100 mL/kg pRBC or serum ferritin [SF] level >1000 μg/L) receiving deferasirox. Patients were followed for up to 3 according standard practice. Results A total 439 evaluated (415...
Rare factor deficiencies (RFDs) are autosomal recessively inherited coagulation encountered at a frequency of between one in 500, 000 and two million.One hundred ninety-two patients, diagnosed as having RFD, followed treated our clinic 1990 2013 were retrospectively evaluated this study.From the 192 142 had FVII, 15 FX, 14 FXI, 10 fibrinogen, six FV, FXIII, FV + FVIII FII deficiency. One thirty cases boys 62 girls. The age range was 2 weeks to 24 years ages admission 16 years. rate...
Among several newly identified oncogenes, dek and af4 are attractive targets for researchers interested with leukemia. In this study quantitative Real-Time RT-PCR technique was used to define alterations in expression of genes associated acute promyelocytic leukaemia (APL) t (15; 17). RNA samples obtained from bone marrow aspirates fourteen APL patients, cDNA portions were labelled Syber Green 1 dye LightCycler analysis have been performed. Expression changes patients found not significant...
Congenital factor deficiencies (CFDs) refer to inherited deficiency of coagulation factors in the blood. A total 481 patients with CFDs, who were diagnosed and followed at our Pediatric Hematology Oncology Clinic between 1990 2015, retrospectively evaluated. Of cases, 134 (27.8%) hemophilia A, 38 (7.9%) B, 57 (11.8%) von Willebrand disease (vWD), 252 (52.3%) rare bleeding disorders (RBDs). The median age time diagnosis study was 4.1 years (range: 2 months 20.4 years) 13.4 7 31.3 years),...
Odaman-Al I, Gezdirici A, Yıldız M, Ersoy G, Aydoğan Şalcıoğlu Z, Tahtakesen TN, Önal H, Küçükemre-Aydın B. A novel mutation in the SLC19A2 gene a Turkish male with thiamine-responsive megaloblastic anemia syndrome. Turk J Pediatr 2019; 61: 257-260. Thiamine-responsive (TRMA) is very rare syndrome characterized by triad of early onset anemia, sensorineural deafness and diabetes mellitus. Here we report, 5-year-old boy who presented transfusion dependent mellitus was diagnosed TRMA. Besides...
Congenital rare factor deficiencies may present in infancy by life-threatening bleedings or not show any symptoms until adulthood. It is reported more commonly countries having consanguineous marriages. Data regarding surgical interventions of congenital are based on case reports and records guidelines. There no well documented separately prepared directories related to pre-surgical prophylactic approaches these deficiencies. Our retrospective study consisted 171 that were followed up our...
This study was organized to determine the efficacy and safety of deferasirox (DFX) in reducing SF patients with transfusion-dependent thalassemia (TDT). is a retrospective, descriptive 101 transfusion- dependent major who were followed for 48 months. Twenty-nine used an alternative chelator either alone or combined, not compliant treatment, changed drug due adverse reactions, had multiple transfusions did complete 4 years DFX use excluded. A total 72 out completed study. decreases noted 6-12...
av vu uz z, , K Ke em ma al l N Ni ifl fll li