A5102953995- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Hemoglobinopathies and Related Disorders
- Cytomegalovirus and herpesvirus research
- Blood Coagulation and Thrombosis Mechanisms
- Hemophilia Treatment and Research
- Immune Cell Function and Interaction
- Neutropenia and Cancer Infections
- Childhood Cancer Survivors' Quality of Life
- Cancer-related gene regulation
- Cleft Lip and Palate Research
- Autoimmune and Inflammatory Disorders Research
- Acute Myeloid Leukemia Research
- Mesenchymal stem cell research
- Neonatal Health and Biochemistry
- Hematological disorders and diagnostics
- Inflammasome and immune disorders
- Adolescent and Pediatric Healthcare
- Fungal Infections and Studies
- Chronic Lymphocytic Leukemia Research
- Parvovirus B19 Infection Studies
- Iron Metabolism and Disorders
- Neurogenetic and Muscular Disorders Research
- Blood disorders and treatments
- Chronic Myeloid Leukemia Treatments
İstanbul Kanuni Sultan Süleyman Eğitim ve Araştırma Hastanesi
2012-2023
Acıbadem University
2015-2023
Istanbul University-Cerrahpaşa
2023
Kent Hastanesi
2021-2022
Acıbadem Adana Hospital
2021-2022
Acıbadem University Atakent Hospital
2015-2020
Istanbul University
2005-2018
Ministry of Justice
2018
Ege University
2017
Bakırköy Psychiatric Hospital
2012
Kaposi sarcoma (KS), a human herpes virus 8 (HHV-8; also called KSHV)–induced endothelial tumor, develops only in small fraction of individuals infected with HHV-8. We hypothesized that inborn errors immunity to HHV-8 might underlie the exceedingly rare development classic KS childhood. report here autosomal recessive OX40 deficiency an otherwise healthy adult childhood-onset KS. is co-stimulatory receptor expressed on activated T cells. Its ligand, OX40L, various cell types, including found...
Despite the introduction of new broad-spectrum antibiotics and antifungal therapies over past decade, infections remains most frequent cause death in patients with neutropenia. The aim this study is to assess effect safety granulocyte transfusions (GTX) for treatment severe life-threatening pediatric febrile neutropenia or defective functions.In study, 35 high-risk functions, who received 111 GTX, were included. GTX used 3 consecutive days during not responding antimicrobial therapy.The mean...
This study evaluated the efficacy of mesenchymal stem cells (MSCs) from bone marrow a third-party donor for refractory aGVHD. We report first experience using MSCs to treat aGVHD in 33 pediatric patients undergoing allogeneic HSCT Turkey. Totally, 68 doses derived were infused. The median dose MSC was 1.18 × 10(6) per kg body weight. Overall, complete response (CR) documented 18 patients, partial (PR) 7 and no (NR) 8 patients. 2-year estimated probability overall survival (OS) achieving CR...
The NOTCH signaling pathway plays important role in the development of multicellular organisms, as it regulates cell proliferation, survival, and differentiation. In adults, is essential for T- or B-lymphocyte lineage commitment. NOTCH1 FBXW7 mutations both lead activation are found majority T-ALL patients. this study, mutation analysis genes was performed 87 pediatric T-ALLs who were treated on ALL-BFM protocols. 19 patients (22%), activating observed either heterodimerization domain PEST 7...
In this study, we aimed to determine serum adrenomedullin levels and compare them with of C-reactive protein (CRP) procalcitonin (PCT). Cancer patients aged 0–18 years who experienced febrile neutropenia attacks were included in the study. Adrenomedullin, CRP, PCT analyzed at admission, day 3, days 7–10 later. Fifty episodes that developed 37 The mean age was 7.5 ± 4.7 (1–18) years. had leukemia (73%), solid tumors (19%), lymphoma (8%). percentages clinically documented infection (CDI),...
Abstract Viral infections remain one of the most important complications following allogeneic HSCT . Few reports compare virus infection between different donor types in pediatric patients. We retrospectively analyzed viral and outcome hundred seventy‐one patients (median 7.38 years) who underwent from matched related (MRD, n = 71), 10 HLA allele‐matched unrelated donors ( MUD 1; 29), 9 2; 40), haploidentical (n 31). PCR screening for BK virus, adenovirus, Epstein‐Barr parvovirus B19, human...
The NOTCH signaling pathway plays important role in the development of multicellular organisms, as it regulates cell proliferation, survival, and differentiation. In adults, is essential for T- or B-lymphocyte lineage commitment. NOTCH1 FBXW7 mutations both lead activation are found majority T-ALL patients. this study, mutation analysis genes was performed 87 pediatric T-ALLs who were treated on ALL-BFM protocols. 19 patients (22%), activating observed either heterodimerization domain PEST 7...
Congenital factor VII deficiency is the most common form of rare coagulation deficiencies. This article presents a retrospective evaluation 73 cases that had been followed at our center. The study consisted 48 males and 25 females (2 months-19 years). Thirty-one (42.5%) them were asymptomatic. Out symptomatic patients, 17 severe clinical symptoms, whereas 8 presented with moderate mild symptoms. symptoms listed in order frequency as follows: epistaxis, petechia or ecchymose, easy bruising,...
Invasive fungal infections (IFIs) are a major cause of infection-related morbidity and mortality in patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT). Data from pediatric settings scarce. To determine the incidence, risk factors outcomes IFIs 180-day period post-transplantation, 408 who underwent HSCT were retrospectively analyzed. The study included only proven probable IFIs. cumulative incidences IFI 2.7%, 5.0%, 6.5% at 30, 100, 180 days respectively. According...
Objective: WNT5A is one of the most studied noncanonical WnT ligands and shown to be deregulated in different tumor types.Our aim was clarify whether hypermethylation might cause low mRnA levels we could restore this downregulation by reversing event.Materials Methods: The expression a large acute lymphoblastic leukemia (ALL) patient group (n=86) quantitative real-time PCR.The methylation status detected methylation-specific PCR (MSPCR) bisulphate sequencing.In order determine has direct...
Achromobacter xylosoxidans is an aerobic gram-negative bacillus and important cause of bacteremia in immunocompromised patients. We describe a leukemia pediatric patient with severe neutropenia who developed A resistant to multiple antibiotics, treated the tigecycline piperacillin-tazobactam addition supportive medications.
Systemic juvenile xanthogranuloma is a rare disease in children. A 10-year-old boy who showed renal, pulmonary, and liver involvement reported. He had pulmonary invasion, renal mass, nodular lesions but no bone involvement. The diagnosis was confirmed by biopsy, which revealed foamy, lipid-laden macrophages with positive CD68, negative CD1a S-100. patient treated pulse high-dose methylprednisolone (10 mg/kg/d for 3 d 6 courses). On 1-year follow-up period after courses therapy resulted...
Abstract T‐cell‐depleted HAPLO HSCT is an option to treat children with high‐risk acute leukemia lacking HLA ‐identical donor. We reviewed the outcome of after (n = 21) and ‐MUD 32) transplantation. The proportion patients ≥CR2 was significantly higher in transplantation than MUD Patients were ABO incompatible There no difference between 2 groups terms engraftment, aGvHD cGv HD , VOD hemorrhagic cystitis, infections, relapse. 5‐year OS found 65.8% 71.1%, respectively (log‐rank 0.51). RFS...
The aim of this study was to determine usefulness measurements maximal systolic velocity the hepatic artery with Doppler ultrasonography in diagnosis venoocclusive disease (VOD) after hematopoietic stem cell transplantation. We prospectively obtained 5 sonograms per patient: pretransplantation, day +1, +7, +14, and +28 on 36 nonconsecutive children who underwent examined artery, portal, splenic veins, thickness gallbladder wall, presence ascites, liver spleen size. VOD based clinical...
Approximately 10% of neonates with Down syndrome may develop a form megakaryoblastic leukemia that usually disappear spontaneously during the first months life. Although it seems to have benign course, also be lethal and severe in some cases, especially hydrops and/or cardiopulmonary failure. Herein, we report male infant who was admitted respiratory distress due pericardial effusion leading tamponade 2 weeks Pericardiosentesis tube replacement combination steroid therapy performed. He...
Cytomegalovirus (CMV) infection is one of the most common complications after allogeneic hematopoietic stem cell transplantations (HSCT). Valganciclovir (VGC) has increasingly been used as prophylaxis against CMV solid organ transplantation, but data on efficacy and safety VGC in pediatric HSCT patients are limited. We present our experience with following ganciclovir (GCV) preemptive therapy patients. A total 46 (38% patients) were found to be positive for reactivation. Patients treated GCV...
Abstract The ABO incompatibility between donor and recipient is not considered a barrier to successful allogeneic HSCT . Nevertheless, conflicting data still exist about the influence of on transplant outcome in pediatric patients with thalassemia. Fifty‐one children beta‐thalassemia major who underwent were enrolled this study. Twenty‐three them (45%) received an ‐incompatible [minor mismatch: six (26%), fourteen (61%), bidirectional three (13%)]. In study, did significantly impair GVHD ,...