A5062815612- Hemophilia Treatment and Research
- Hemoglobinopathies and Related Disorders
- Hematopoietic Stem Cell Transplantation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Platelet Disorders and Treatments
- Iron Metabolism and Disorders
- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- Blood groups and transfusion
- Blood Coagulation and Thrombosis Mechanisms
- Blood disorders and treatments
- Cancer-related gene regulation
- Erythrocyte Function and Pathophysiology
- Oral and gingival health research
- Acute Lymphoblastic Leukemia research
- Neutropenia and Cancer Infections
- Immunodeficiency and Autoimmune Disorders
- Neonatal Health and Biochemistry
- Oral health in cancer treatment
- Amyloidosis: Diagnosis, Treatment, Outcomes
- COVID-19 Clinical Research Studies
- Childhood Cancer Survivors' Quality of Life
- Case Reports on Hematomas
- Antifungal resistance and susceptibility
- HIV/AIDS oral health manifestations
Acıbadem Adana Hospital
2016-2025
Acıbadem University
2018-2025
European Society for Blood and Marrow Transplantation
2025
Cukurova University
2008-2024
Leiden University Medical Center
2017
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2017
University of Milan
2017
The development of neutralizing anti–factor VIII alloantibodies (inhibitors) in patients with severe hemophilia A may depend on the concentrate used for replacement therapy.
Introduction: Letermovir is a cytomegalovirus (CMV) terminase complex inhibitor approved for prophylaxis of CMV infection and disease in adult CMV-seropositive allogeneic hematopoietic cell transplantation (allo-HCT) recipients (R+). We report pharmacokinetics (PK), safety, efficacy letermovir adolescent (12–18 years) HCT from an ongoing clinical study. Methods: In this phase 2b, multicenter, open-label study (NCT03940586), 28 adolescents received 480 mg [240 with cyclosporin A (CsA)] once...
BAY 81-8973 is a new full-length human recombinant factor VIII product manufactured with technologies to improve consistency in glycosylation and expression optimize clinical performance.To demonstrate superiority of prophylaxis vs. on demand therapy patients severe hemophilia A.In this multinational,randomized, open-label crossover study (LEOPOLD II;ClinicalTrials.gov identifier: NCT01233258), males aged 12–65 years A were randomized twice-weekly (20-30 IU kg(-1)), 3-times-weekly (30-40 or...
Fitusiran, a subcutaneous investigational small interfering RNA therapeutic, targets antithrombin to rebalance hemostasis in people with hemophilia A or B (PwHA/B), irrespective of inhibitor status. This phase 3, open-label study evaluated the efficacy and safety fitusiran prophylaxis males aged ≥12 years B, without inhibitors, who received prior bypassing agent (BPA)/clotting factor concentrate (CFC) prophylaxis. Participants continued their BPA/CFC for 6 months before switching...
Background/Aims: Preimplantation genetic diagnosis (PGD) with human leukocyte antigen (HLA) typing represents a significant advancement in treating inherited hematological disorders, particularly thalassemia major.This technology enables the birth of healthy children who can serve as compatible stem cell donors for their affected siblings.Turkey is world leader both PGD+HLA and hematopoietic transplantation from savior siblings born through typing.Aims: This study investigated experiences...
Patients with haemophilia A and inhibitors are at high risk for severe bleeding, progression of joint disease deterioration health-related quality life (HRQoL). To determine the impact prophylaxis an activated prothrombin complex concentrate (aPCC) on HRQoL, HRQoL was assessed using Short-Form (SF)-36 Health Survey EQ-5D questionnaire in subjects ≥ 14 years participating a prospective, randomized, crossover study comparing 6 months aPCC on-demand therapy. Eighteen 19 patients completed...
Background/Objectives: Childhood hemophilia, a hereditary bleeding disorder predominantly affecting males, arises due to gene mutations encoding clotting factors VIII or IX. Intracranial hemorrhage represents significant and life-threatening complication in pediatric patients with hemophilia. The incidence of intracranial children although relatively low, is notably higher compared the general population. Methods: In this study, objective examine hemophilia who have experienced...
This study aimed to determine the effect of haemolysis on plasma oxidation and nitration in sickle cell disease (SCD) patients. Blood was collected from haemoglobin (Hb)A volunteers homozygous HbSS patients who had not received blood transfusions last 3 months. Haemolysis characterised by low levels haptoglobin high reticulocyte, mean corpuscular volume (MCV), (MCH), cell-free haemoglobin, bilirubin, total lactate dehydrogenase (LDH) dominance LDH-1 isoenzyme. Plasma 8-isoprostane, protein...
Abstract Introduction The effects of manual therapy (MT) on joint health and functional level in haemophilic arthropathy (HA) have relatively under‐explored. Aim To investigate the MT HA lower limb joints musculoskeletal system, level, Functional Independence Score Hemophilia (FISH), Joint Health (HJHS) kinesiophobia. Methods Seventeen patients were randomized to control group (CG = 9) (MTG 8). number haemarthrosis (NoH) was recorded from diaries. Range motion (ROM), strength pain intensity...
The study aimed to compare the effects of three different methods umbilical cord management on hematological parameters in term and late-preterm infants.A randomized controlled trial comparing intact-umbilical milking (I-UCM) with cut-umbilical (C-UCM) immediate clamping (ICC) neonates born >35 weeks' gestation.A total 587 infants were evaluated. Of these, 197 assigned I-UCM, 190 C-UCM, 200 ICC. Mean hemoglobin hematocrit levels at 48 hours age higher I-UCM group compared ICC (p = 0.002 p...
Haemophilic arthropathy is likely to influence posture and muscle stiffness in adolescent male haemophilia patients (HP).
Abstract In children with high‐risk childhood acute leukemia who undergo allogeneic hematopoietic stem‐cell transplantation (allo‐HSCT), relapse is still the leading cause of treatment failure. The prognosis poor, yet prospective studies have only limited data on risk factors and outcomes. We aimed to understand outcomes prognostic for patients lymphoblastic (ALL) relapsed following allo‐HSCT. analyzed retrospectively 46 had after receiving their first alloHSCT. All these received salvage...
Granulocytic sarcoma (GS) is an uncommon extramedullary tumor composed of dense aggregates immature myeloid precursor cells, which usually associated with acute or chronic leukemia. The may also be a predecessor to leukemia (AML). It found in any location throughout the body; however, intraoral occurrence extremely rare. This report describes case gingival granulocytic that developed prior AML 12-year-old female.The patient, who had 3-month history enlargement, was diagnosed as having based...
Among children with haemophilia and their caregivers; problems arising from the teeth surrounding tissues have an important role in treatment of this disease it affects quality life parents.Aim study is to evaluate oral health-related perspective parents.Paediatric (POQL) instrument was used cross-sectional for measurement. The research data collected by questionnaire form were coded scale items personal information questions transferred SPSS, a multivariate statistical analysis program...
Abstract Introduction Effective physiotherapy interventions are required for haemophilic arthropathy (HA) of the elbow due to its biomechanical differences and contribution upper limb functionality. Aim To investigate effects manual therapy & exercises on bleeding frequency, pain, range motion (ROM), strength, joint health, functionality quality life (QoL) in HA elbow. Methods Seventeen participants with were randomized as Manual Therapy Exercises Group (MTEG = 9) Home (HEG 8). Soft...