A5085134768- Blood Coagulation and Thrombosis Mechanisms
- Parvovirus B19 Infection Studies
- Neonatal Respiratory Health Research
- Histiocytic Disorders and Treatments
- Neonatal and Maternal Infections
- Platelet Disorders and Treatments
- Congenital Heart Disease Studies
- Eosinophilic Disorders and Syndromes
- Nosocomial Infections in ICU
- Viral-associated cancers and disorders
- Thyroid Disorders and Treatments
- Muscle and Compartmental Disorders
- Pediatric Urology and Nephrology Studies
- Sepsis Diagnosis and Treatment
- Renal Diseases and Glomerulopathies
- Pharmacological Effects and Toxicity Studies
- Immune Cell Function and Interaction
- Erythrocyte Function and Pathophysiology
- Asthma and respiratory diseases
- Hemophilia Treatment and Research
- Immunodeficiency and Autoimmune Disorders
- Connective tissue disorders research
- Vasculitis and related conditions
- Ion channel regulation and function
- Neonatal and fetal brain pathology
Clinical Centre of Kragujevac
2015-2025
University of Kragujevac
2015-2025
Advanced Neural Dynamics (United States)
2021
Rambam Health Care Campus
2013
Ocní klinika
2010
University Children's Hospital, Belgrade
1997
BAY 81-8973 is a new full-length human recombinant factor VIII product manufactured with technologies to improve consistency in glycosylation and expression optimize clinical performance.To demonstrate superiority of prophylaxis vs. on demand therapy patients severe hemophilia A.In this multinational,randomized, open-label crossover study (LEOPOLD II;ClinicalTrials.gov identifier: NCT01233258), males aged 12–65 years A were randomized twice-weekly (20-30 IU kg(-1)), 3-times-weekly (30-40 or...
Background: Monosomy 18p is a chromosomal disorder resulting from the deletion of short arm chromosome 18. While lot cases result partial 18p, only few reported are caused by whole 18 due to unbalanced translocations occurring between chromosomes 13 and (13;18). 18p- monosomy presents with variety clinical manifestations, including facial dysmorphism, intellectual disability, stature, among others. Case presentation: Here, we report case one-year-old girl an translocation (45, XX, t(13;18)...
Introduction. Infective mononucleosis is most commonly caused by Epstein-Barr virus (EBV), and in smaller percentage cytomegalovirus (CMV). Objective. The aim of this paper was to determine the clinical laboratory differences between EBV CMV infectious children. Methods. Cohort retrospective analytical research conducted. We used data from medical history six years period monitored anamnestic data, frequency inspection palpation obtained during physical examination, several tests, abdomen...
Introduction. Hypocalcemic seizures are uncommon in the post-neonatal period. We report an infant with hypocalcemic caused by severe deficiency of vitamin D. Case Outline. A five-month-old male was admitted to hospital March 2013 recurrent generalized afebrile resistant clonazepam therapy. At clinical examination, showed characteristic rachitic signs, so that after a blood sample taken for laboratory testing, given infusion 2 ml/kg 10% calcium gluconate at rate 0.5 ml/min. The treatment...
INTRODUCTION Hashimoto's thyroiditis (HT) is a common cause of goitre and hypothyroidism in children adolescents. Spontaneous remission may occur up to 50% patients, but the development possible. OBJECTIVE We investigated clinical manifestations, course long-term outcome HT. METHOD reviewed charts 43 (36 females) with HT, mean age at presentation 12.3 years, follow-up duration 4.6 years. RESULTS HT five times more females. The complaints leading referral were 19 (44.3%), diffuse 17 (89.5%)....
Pseudo-Bartter syndrome encompasses a heterogenous group of disorders similar to Bartter syndrome. We are presenting an infant with pseudo-Bartter caused by congenital chloride diarrhoea.A male newborn born in the 37th gestational week (GW) young healthy and non-consanguineous parents. In 35th GW polyhydramnios bowel dilatation was verified ultrasonography. After birth he manifested several episodes hyponatremic dehydration hypochloraemia, hypokalaemia metabolic alkalosis, so as suspected...
Background/Aim. Myocardial cell lesion in newborns may be clinically occult. In recent years there has been shown growing interest the use of cardiac troponin-I (cTnI) relation to perinatal asphyxia and hypoxic myocardial lesion. The aim this study was determine a relationship between high cTnI levels outcome critically ill with asphyxia. Methods. 78 patients were divided into three groups. group I included 39 (15 term 24 preterm) asphyxia, no deaths, only full or partial (with some...
Introduction. In the last few years use of cardiac troponin I and T, as diagnostic prognostic factors ischemic myocardial injury both in adult neonatal medicine has been great interest. Objective. The objective our research was to investigate significance (sTnI) an early indicator presence severity hypoxic-ischemic encephalopathy (HIE) newborns. Methods. We analyzed 55 term newborns with HIE diagnosed based on clinical findings ultrasonographic examination central nervous system. Serum...
Abstract Henoch-Schönlein purpura is a type of systemic small vessel vasculitis. The dominant manifestation the cutaneous component, illness self-limiting in nature, and prognosis outcome depend mostly on renal manifestations. We analysed associations among clinical laboratory parameters with HSP children hospitalised at Paediatrics clinic, Clinical Centre, Kragujevac between January 2011 2012. Children who developed nephritis were older average all manifested arthritis, abdominal...
Introduction. Schimke immuno-osseous dysplasia (SIOD) is a rare autosomal recessive multisystem disorder associated with biallelic mutations of the SMAR-CAL1 gene. Vascular central nervous system complications in form Moyamoya syndrome (MMS) have been reported as comorbidity nearly half patients clinically presenting severe migraine-like headaches, transient ischemic attacks (TIA), and or hemorrhagic infarctions. We present an illustrative case infantile SIOD MMS, review latest diagnostic...
Introduction: Purified factor IX (FIX) concentrate (IMMUNINE ® , Takeda Manufacturing Austria AG, Vienna, Austria) is indicated for the treatment and prophylaxis of bleeding episodes in patients with congenital hemophilia B. Data on use purified FIX ≤ 6 years old B are limited. Aim: Document real-world clinical experience routine practice pediatric Methods: This prospective post-authorization safety surveillance study enrolled moderate or severe (baseline 5%) who were prescribed concentrate,...
Introduction. Asthma is the most frequent children?s disease, with a tendency of further growth. Bearing in mind controversial data on obesity asthmatic children and possible effect inhaled corticosteroids (ICS) growth, aim our study was to determine body mass index (BMI) at beginning therapy continuous application ICS growth BMI during period 1 year. Material methods. The included 100 aged 7 18 diagnosed have partly controlled uncontrolled allergic asthma, who were continuously given as...
INTRODUCTION Epilepsy is a highly prevalent disease affecting 0.5-1.5% of the world's population. One most frequently used antiepileptics are valproates. These medicines show negative impact on haemostasis and peripheral blood count. OBJECTIVE The objective study was to examine valproates count in children analyse whether these disturbances were dependent dosage drug level blood. METHOD A two-year research conducted. included: 35 using valproates, 12 therapy both carbamazepine 30 healthy...
Background. Acute hemorrhagic edema of infancy (AHEI) is a rare vasculitis, which presents dramatically as palpable purpuric skin lesions on the limb, face and auricles, with swelling these parts low-grade fever, in children up to 2 years age. To date, approximately 400 cases have been described literature. The etiology remains mostly unknown. With or without treatment, AHEI goes spontaneous recovery within 1-3 weeks, usually any complications. our knowledge, compartment syndrome...
Malignant hyperthermia is a rare disease which mainly an inherited autosomal dominant trait. It characteristic for muscle rigidity, metabolism or respiratory acidosis, high values of serum creatine kinase. Then appears myoglobinuria can lead to tubular necrosis and acute renal failure.The male child, ten years old, hospitalized because the temperature, exhaustion cough. On second day hospitalization, he has (39.8 degrees C), dyspnoea, tachypnoea, was somnolent, occasionally raving, exhausted...
Congenital hepatic fi brosis (CHF) is a rare developmental disorder of the portobiliary system and most commonly associated with polycystic kidney disease. The pattern inheritance this autosomal recessive. exact prevalence CHF unknown (estimated from 1:10000 to 1:20000). Sequelae portal hypertension have been found in less than half all patients were age. We present case study boy complicated by hypertension, splenomegaly hypersplenism. Tis patient was diagnosed cholestatic syndrome as...
Clostridium difficile (CD) is the most common cause of nosocomial diarrhea in adults with high rates morbidity and mortality. The epidemiology CD infection (CDI) has changed last few decades associated increasing severity rate related to occurrence NAP1 hypervirulent strain emergence disease among ambulatory patients wider community. Although little known about CDI pediatric patients, surprisingly recognized as an important pathogen children. In this review article, we direct attention...
Abstract Tromboses are considered to be rare disorders in the pediatric population. However, they occur more frequently during neonatal period. Potential risk factors for thrombosis onset include frequent use of peripheral, umbilical or central venous / arterial catheters, inflammation, disseminated intravascular coagulation, liver disorders, hypovolemia, asphyxia, congenital heart disease, polycythemia and dehydration. On seventh day life male premature infant born 29th 30th gestation week,...
Klippel-Trenaunay-Weber syndrome (KTW) is a rare phacomatosis whose main characteristics are: cutaneous angiomas (vascular nevi), varicose veins (arteriovenous fistulae) and hemihypertrophy of bones soft tissues. This case report KTW which was diagnosed in the first days life on basis characteristic vascular nevi skin trunk extremities addition to hypertrophy left part body. Neuroradiologically verified hemimegalencephaly associated with temporal hemangioma represents special particularity...