The aim of our study was to investigate the role ABCB1 polymorphism in pharmacokinetics carbamazepine (CBZ) children. enrolled 47 Serbian pediatric epileptic patients on CBZ treatment. Genotyping for 1236C<T (rs1128503), 2677G<A/T (rs2032582) and 3435C<T (rs1045642) carried out using TaqMan method. Steady-state serum concentrations were available from previous study, determined by high pressure liquid chromatography (HPLC). NONMEM software one-compartment model used pharmacokinetic...

Under the influence of numerous life factors, speech constantly undergoes changes. Parents children with and language disorders have a lower quality compared to parents without. The study examined different domains families without disorders. A cross-sectional was conducted in Serbia, 2024, on sample 206 preschool aged 5-7 years their parents/guardians. As research instrument, addition General Questionnaire sociodemographic characteristics parents' respondents/guardians, Family Quality Life...

Targeting the Mdm2 oncoprotein by drugs has potential of re-establishing p53 function and tumor suppression. However, Mdm2-antagonizing drug candidates, e. g. Nutlin-3a, often fail to abolish cancer cell growth sustainably. To overcome these limitations, we inhibited simultaneously a second negative regulator p53, phosphatase Wip1/PPM1D. When combining Nutlin-3a with Wip1 inhibitor GSK2830371 in treatment p53-proficient but not p53-deficient cells, observed enhanced phosphorylation (Ser 15)...

Introduction. Infective mononucleosis is most commonly caused by Epstein-Barr virus (EBV), and in smaller percentage cytomegalovirus (CMV). Objective. The aim of this paper was to determine the clinical laboratory differences between EBV CMV infectious children. Methods. Cohort retrospective analytical research conducted. We used data from medical history six years period monitored anamnestic data, frequency inspection palpation obtained during physical examination, several tests, abdomen...

Abstract Carbamazepine exhibits significant inter-individual variability in its efficacy and safety, which leads to unpredictable therapy outcomes for the majority of patients. Although complex biotransformation depends on CYP3A5 activity, evidence association between carbamazepine treatment functional variations remains inconclusive. The aim present study was investigate distribution two functionally important variants *2 *3 as well their effects dose requirements, plasma concentrations...

Abstract The aim of the present study was to investigate distribution CYP2C8 variants *3 and *5 , as well their effect on carbamazepine pharmacokinetic properties, in 40 epileptic pediatric patients treatment. Genotyping conducted using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), allele-specific (AS)-PCR methods, steady-state plasma concentrations were determined by high performance liquid chromatography (HPLC). polymorphisms found at frequencies 17.5 0.0%,...

Introduction. In the last few years use of cardiac troponin I and T, as diagnostic prognostic factors ischemic myocardial injury both in adult neonatal medicine has been great interest. Objective. The objective our research was to investigate significance (sTnI) an early indicator presence severity hypoxic-ischemic encephalopathy (HIE) newborns. Methods. We analyzed 55 term newborns with HIE diagnosed based on clinical findings ultrasonographic examination central nervous system. Serum...

Introduction. Schimke immuno-osseous dysplasia (SIOD) is a rare autosomal recessive multisystem disorder associated with biallelic mutations of the SMAR-CAL1 gene. Vascular central nervous system complications in form Moyamoya syndrome (MMS) have been reported as comorbidity nearly half patients clinically presenting severe migraine-like headaches, transient ischemic attacks (TIA), and or hemorrhagic infarctions. We present an illustrative case infantile SIOD MMS, review latest diagnostic...

Background/Objectives: The aim of our study was to investigate the role ABCB1 polymorphism in pharmacokinetics carbamazepine (CBZ) children. Methods: enrolled 47 Serbian pediatric epileptic patients on CBZ treatment. Genotyping for 1236C<T (rs1128503), 2677G<A/T (rs2032582) and 3435C<T (rs1045642) carried out using TaqMan method. Steady-state serum concentrations were available from previous study, determined by high pressure liquid chromatography (HPLC)...

Brain abscesses were neurosongraphically diagnosed in 3 out of 44 neonates who had confirmed purulent meningitis. In two cases, the cause was Proteus mirabillis, whereas one could not be isolated. The ultrasound finding indicated abscess cavities localized frontal (in case bilaterally) and temporal regions CNS. Neurosurgical interventions carried on all (including evacuation cavity contents, later a ventriculoperitoneal shunt because development hydrocephalus). Follow-up operated infants...

Abstract Valproate represents one of the most commonly used anticonvulsants worldwide, whose narrow therapeutic range and high potential for drug-drug interactions leads to pronounced intra- inter-individual variability in plasma concentration response. The aim our study was apply population pharmacokinetics analysis comprehensively investigate detect important factors affecting valproate Serbian children with epilepsy. This retrospective observational based on demographic medical data...

The aim of this paper is to analyse the health state pre-school children in Shumadia district for identification priority problems. data source were Reports diseases, states and injuries from primary centers, departments protection preschool children, period 1999. 2008. In population district, rate diseases increases, we observed, 5086/1000 age between 0 6 6668/1000 0and morbidity structure, pulmonal are dominating with 64,5%

and severe LV systolic dysfunction are independent predictors of sudden cardiac death.However, it has been uncertain the significance remode-lling function for appearing VA during ischaemia in patients with coronary artery disease (CAD) without heart failure arterial hypertension.Aim: To compare geometry CAD occurring myocardial ischaemia.Methods: We studied 48 who had electrocardiographic signs ergometer exercise testing.Nitrates, calcium antagonists ß-blockers were abolished day before...

Abstract Erythema nodosum (EN) is a poly-etiological disease with an acute flow that characterized by symmetric emergence of painful nodules often in pretibial areas. A twenty-month-old male child was admitted to hospital for evaluation the eruptive skin changes lower extremities and forearms. The began 10 days before getting febricity loose stools. laboratory analysis showed elevated erythrocyte sedimentation rate leukocytosis. Blood cultures demonstrated presence coagulase-negative...

Background: Periventricular/intraventricular hemorrhage (PVH/IVH) has a major impact on neurodevelopment due to its complications and sequelae. Objectives: This study aimed determine the frequency of neurosonographic examination length monitoring period in children diagnosed with PVH/IVH. Methods: clinical observational analytical retrospective cohort was performed 102 The examinations were done third, seventh, fourteenth, twenty-first days after birth then fourth sixth weeks third months...

Abstract Apert syndrome (Acrocephalosyndactylia type 1) belongs to the group of extremely rare congenital dysmorphic syndromes. It is characterized by craniostenosis with very early fusion skull and / or cranial base sutures, facial hypoplasia, symmetrical syndactyly fingers toes other systemic malformations. Multiple CNS abnormalities are common, but simultaneous occurrence agenesis corpus callosum estimated about 10%. We present a male patient born after first, normal controlled pregnancy...

The aim was to determine hematological and biochemical changes in children who are carriers of SARS-CoV-2. Unlike H1N1 influenza-like illness the predictive factors SARS-CoV-2 asymptomatic (carriers SARS-CoV-2) distinctive ratio between lymphocytes monocytes more than 2, with occasional eosinophila, a dicrease erythrocyte indices (MCH MCV), rapid strong increase serum LDH value. are, presumably, useful for fast cheap triage “from contact” until PCR test result arrives.