To investigate whether duration of breastfeeding and timing gluten introduction influence the age at diagnosis severity celiac disease.Medical records 89 infants (59 girls 30 boys; mean 14.2 months, standard deviation 4.80) diagnosed with classic disease University Children's Hospital in Belgrade from 2000 to 2008 were retrospectively analyzed determine introduction. The was assessed based on weight loss, longitudinal growth retardation, anemia, secondary lactose intolerance.Longer...

Celiac disease (CD) is a chronic inflammatory in the small intestine triggered by gluten uptake that occurs genetically susceptible individuals. HLA-DQ2 protein encoded HLA-DQA1*05 and DQB1*02 alleles found 90-95% of CD patients. All remaining patients carry HLA-DQ8 HLA-DQA1*03 DQB1*03:02 alleles. Specific HLA-DQ genotypes define different risk for incidence. Presence does not predict certain development, but their absence makes very unlikely, close to 100%. Here we presented first time...

Introduction. Gluten-free diet (GFD) presents the basis of coeliac disease (CD) treatment. If strictly applied, disorders small bowel mucosa and other signs rapidly resolve. Objective. The goal study was to evaluate effect GFD on growth nutritional status children with classical form CD. In addition, we analyzed differences between these parameters duration patients' compliance GFD. Methods. goals were achieved a sample 90 children, 56 female 34 male, aged 0.5-7.5 (1.53?1.05) years, classic...

Introduction. Closed reduction and percutaneous pinning are the most widely used treatment options for displaced supracondylar humerus fractures in children, but there is still no consensus concerning preferred technique injuries of extension type. Objective. The aim this study was to compare three common orthopaedic procedures type children. Methods. Total 93 consecutive patients (66 boys 27 girls) referred our hospital with Gartland II or III humeral were prospectively included over a...

Background and Objectives: The immature skeleton in a pediatric population exposed to frequent physical activity might be extremely prone injuries, with possible consequences later adulthood. main aim of this study is present specific morphometric parameters magnetic resonance imaging (MRI) morphological changes the knee patella physically active population. Additionally, we wanted investigate risk factors for patellar instability. Materials Methods: included MRI findings 193 patients pain....

To assess the prevalence and risk factors of celiac crisis (CC) in children with classical disease (CD). This retrospective study comprised 367 CD diagnosed from 1994 to 2015. The diagnosis was based on revised ESPGHAN criteria CC acute worsening rapid progression chronic diarrhea vomiting followed by severe dehydration, multiple metabolic derangements a marked decrease body weight. Celiac confirmed six (1.63 %) children, five first one second year life. In three patients precipitated...

Introduction. Insertion of a ventriculoperitoneal (VP) shunt, the method choice in treatment hydrocephalus, is often followed by various mechanical and/or infective complications. We present two children with asymptomatic perforation large bowel and urinary bladder, relatively rare potentially severe complications this surgical procedure. Outline Cases. In both patients VP shunt was implanted first month after birth; boy due to congenital hydrocephalus girl consequences intracranial...

Introduction. Parenteral nutrition-associated cholestasis is well recognized phenomenon in the term and preterm infant receiving long-term parenteral nutrition. Objectives. The aim of this study was to evaluate effect ursodeoxycholic acid (UDCA) use on newborns prolonged TPN. Methods. A total 56 infants were enrolled retrospective study: control group consisted lower (1500 g) birth weight (n=30), as pediatric (n=11) surgical patients (n=15) treated with UDCA. Blood chemistries obtained two...

Introduction. Vitamin D intoxication represents a rare and potentially serious pathological condition caused by the excess of calcium phosphorus. We are presenting an infant with vitamin due to excessive daily administration, as well therapeutic procedures that prevented its adverse effects. Case Outline. A 1.5-month-old female infant, born at term, exclusively breastfed without any complaints abnormalities physical findings, was observed data during preceding month, her mother?s mistake,...

Introduction. X-linked hypophosphatemic rickets (XLHR) is a dominant inherited disease caused by isolated renal phosphate wasting and impairment of vitamin D activation. We present girl with as consequence de novo mutation in the PHEX gene. Case Outline. A 2.2-year-old presented prominent lower limb rachitic deformity, waddling gait disproportionate short stature (79 cm, <P5; -1,85 SD). On basis hypophosphatemia, hyperphosphaturia, high serum level alkaline phosphatase, normal calcemia,...

Secondary lactose intolerance (SLI) belongs to the rarer manifestations of gluten-sensitive enteropathy (GSE). It occurs in more severe forms disease and its presence contributes significantly degree expression.The goal study was determine frequency SLI infants with clinically classic form GSE, as well relationship duration, severity age at diagnosis basic small bowel mucosa damage.The based on a sample 42 infants, 30 female 12 male, aged 7-12 months (x = 9.98 +/- 1.69), GSE. The GSE...

Introduction. Hypocalcemic seizures are uncommon in the post-neonatal period. We report an infant with hypocalcemic caused by severe deficiency of vitamin D. Case Outline. A five-month-old male was admitted to hospital March 2013 recurrent generalized afebrile resistant clonazepam therapy. At clinical examination, showed characteristic rachitic signs, so that after a blood sample taken for laboratory testing, given infusion 2 ml/kg 10% calcium gluconate at rate 0.5 ml/min. The treatment...

Hirschsprung's disease is the most common identifiable developmental disorder of enteric nervous system, characterized by a failure its formation in variable segment distal bowel. Currently available surgical therapies for disease, although lifesaving, are associated with numerous complications. The aim our study was to evaluate effectiveness different methods and incidence serious complications after radical surgery rectosigmoid disease.A retrospective analysis, from June 1997 until May...

Introduction. Athersclerosis is a multifactorial disease that begins in childhood. There are few reports regarding influence of risk factors on the atherosclerotic processes early period life and adolescence. Objective. The aim this study was to present analyze factor trends school children over 10-year were included followed-up by Yugoslav Study Atherosclerosis Precursors School Children (YUSAD Study). Methods. three examinations selected population from 13 centres. first examination...

Introduction. Alpha-1-antitrypsin deficiency (AATD) is a relatively rare and clinically very heterogeneous autosomal recessive disorder. Objective. Presentation of clinical characteristics AATD in the first months after birth, as well significance testing brothers sisters for its presence. Methods. Objectives study were analyzed on sample eight children (four male four female, aged 63 (mean14.81?23.96 months; range 1-63 months) with confirmed based low serum value pathological phenotype....

Introduction. Natural course of aneurysms that occur on blood vessels the brain singles out need for understanding mechanism occurrence aneurysm wall rupture and identification anatomic characteristics as predictive factors hemorrhage to occur. Objective. In this study we comparatively present results our researches experimental models animals. Methods. We made a comparative analysis anatomical obtained basis digital subtraction angiography intraoperative finding. article review recent...

Introduction/Objective. Gilbert syndrome (GS) is the most common hereditary hyperbilirubinemia. As well as mild unconjugated hyperbilirubinemia, it characterized by excess of bilirubin monoglucuronide over diglucuronide in bile and thus increases risk biliary calculosis. The aim study was to determine importance GS a factor development cholelithiasis children. Methods. included sample 31 children (14 male 17 female, mean age 12.16 ? 4.11 years, range 3?16.75 years) with symptomatic...

Introduction/Objective. Celiac disease (CD) is the result of a polygenic predisposition and gluten-containing diet. The aim this study was to determine prevalence clinical forms CD in siblings children with verified disease. Methods. included 83 siblings, aged 1.5?27 (11.77 ? 6.2) years, 64 diagnosed according ESPGHAN criteria (1990/2012). In addition detailed history examination, serum levels IgA antibodies tissue transglutaminase (AtTG) IgG classes were determined all subjects. All...

Introduction: Gilbert?s syndrome represents the most frequent hereditary disorder of bilirubin metabolism. It occurs in 2-7% subjects general population, and is manifested by mild unconjugated hyperbilirubinaemia benign nature. Objective. The study was conducted order to analyse our experience related circumstances disclosure, age at onset sex distribution children. Method. diagnosis based on findings absence haemolysis organic liver disease, as well significant increase fraction serum after...