A5013828567- Blood Coagulation and Thrombosis Mechanisms
- Acute Lymphoblastic Leukemia research
- Hemoglobinopathies and Related Disorders
- Hematopoietic Stem Cell Transplantation
- Childhood Cancer Survivors' Quality of Life
- Acute Myeloid Leukemia Research
- Pharmaceutical studies and practices
- Fungal Infections and Studies
- Hemophilia Treatment and Research
- Chronic Myeloid Leukemia Treatments
- Antifungal resistance and susceptibility
- Chronic Lymphocytic Leukemia Research
- Vascular anomalies and interventions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Helicobacter pylori-related gastroenterology studies
- Venous Thromboembolism Diagnosis and Management
- Lysosomal Storage Disorders Research
- Central Venous Catheters and Hemodialysis
- Neutropenia and Cancer Infections
- Prenatal Screening and Diagnostics
- Platelet Disorders and Treatments
- Urticaria and Related Conditions
- Genetic Syndromes and Imprinting
- DNA Repair Mechanisms
- Trauma, Hemostasis, Coagulopathy, Resuscitation
Selçuk University
2024
Sağlık Bilimleri Üniversitesi
2022
Memorial Ankara Hospital
2017-2019
TOBB University of Economics and Technology
2018
Turkish Armed Forces
2004-2016
Military Medical Academy
2007-2015
Başkent University
2012
Gülhane Askerî Tıp Akademisi
2010
Ankara University
2002
Children's Hospital of Pittsburgh
1997-1998
Yesilipek MA, Ertem M, Cetin Öniz H, Kansoy S, Tanyeli A, Anak Kurekci E, Hazar V. HLA‐matched family hematopoetic stem cell transplantation in children with beta thalassemia major: The experience of the Turkish Pediatric Bone Marrow Transplantation Group. Abstract: From January 1991 to June 2009, 245 major who underwent their first allogeneic HSCT Turkey and were followed for a minimum one yr post‐transplantation enrolled this study. median age patients was 6.6 old (range, 1–22 yr)....
The aim of this study was to investigate the changes in peripheral blood newborns hypertensive mothers. umbilical cord from 31 mothers and 32 healthy were examined. In all subjects, complete count, smear, reticulocyte vitamin B12, folate, ferritin levels hemoglobin electrophoresis performed. subjects followed up on for 1 year terms infections. RBC, hemoglobin, count normoblast higher compared control group, total leukocytes, neutrophil, lymphocyte, monocyte, eosinophil, thrombocyte counts...
This study analyzes the data of thrombotic children who were followed up in different pediatric referral centers Turkey, to obtain more general on diagnosis, risk factors, management, and outcome thrombosis Turkish children. A simple two-page questionnaire was distributed among contact people from each center standardize collection. Thirteen responded invitation total number cases 271. All diagnosed with thromboembolic disease between January 1995 October 2001. Median age at time first event...
Transfusion of platelet suspensions is an essential part patient care for certain clinical indications. In this pioneering study in Turkey, we aimed to assess the vitro hemostatic functions platelets after cryopreservation.Seven units concentrates were obtained by apheresis. Each apheresis concentrate (APC) was divided into 2 equal volumes and frozen with 6% dimethyl sulfoxide (DMSO). The 14 APCs kept at -80 °C 1 day. thawed 37 diluted either autologous plasma or 0.9% NaCl. volume residual...
Preimplantation genetic diagnosis involves the of a disorder in embryos obtained through vitro fertilization, selection healthy embryos, and transfer to mother's uterus. has been used not only avoid risk having an affected child, but it also offers, using HLA matching, preselection potential HLA-genoidentical donor progeny for sibling who requires bone marrow transplantation. Here, we share hematopoietic stem cell transplantation results 52 patients with different benign malign hematological...
Objective: To retrospectively evaluate the clinical findings, laboratory data, management, and outcome in a group of Turkish children diagnosed with rare coagulation deficiencies (RCDs) between January 1999 June 2009.Material Methods: The Society Pediatric Hematology-Hemophilia-Thrombosis-Hemostasis subcommittee designed Microsoft Excel-based questionnaire for standardized data collection sent it to participating institutions.Results: In total, 156 patients from 12 pediatric referral centers...
Invasive fungal infections, including hepatosplenic infections (HSFI), cause significant morbidity and mortality in children with leukemia. There are not enough data to support for the best approach diagnosis of HSFI children, nor treatment.In this multicentric study, we assessed demographic data, clinical radiologic features, treatment, outcome 40 leukemia from 12 centers.All cases were radiologically diagnosed abdominal ultrasound, which was performed at a median 7 days, febrile...
Budd–Chiari syndrome is a heterogeneous group of disorders characterized by hepatic venous outflow obstruction. Although there are no guidelines for treatment patients with syndrome, thrombolytic therapy may be useful in acute syndrome. In this report, boy due to membranous obstruction the inferior vena cava treated systemic and local administration recombinant tissue plasminogen activator described. We would like emphasize role fibrinolytic these patients.
This study was undertaken to determine the prevalence of Factor V 1691 G-A and PT 20210 mutations in Turkish children with leukemia. We genotyped 135 pediatric leukemia patients for these mutations. Eleven (8%) were heterozygous FV mutation. Seven (5,1%) carried Of patients, only three had thrombotic event, none which two mutations, is common population. Our findings revealed a controversial compared previous reports, needs further investigation.
OBJECTIVES: The CCAAT/enhancer-binding protein-alpha (CEBPA) is lineage-specifi c transcription factor in the hematopoietic system.In this study, we aimed on clinical features and prognostic signifi cance associated with CEBPA mutations 30 pediatric patients acute leukemia.METHODS: In addition, association between found variants of Ten-Eleven-Translocation 2 (TET2), Kirsten rat sarcoma viral oncogene homolog (KRAS), Casitas B-cell lymphoma (CBL), FLT3 (Fms-Related Tyrosine Kinase), JAK2...
Background: Platelet-rich plasma (PRP) has been widely used to improve wound healing and tissue repair.The objective of this study was assess a cycle freezing/thawing its effect in the amount growth factors PRP.Materials methods: After preparation PRP using standard methods, samples were equally divided into two groups: The first group activated by adding 10% calcium gluconate, while second cryopreserved at -80°C for 24 hours.Enzyme-linked immunosorbent assay aliquots measure concentrations...
Anticardiolipin (aCL) antibodies are associated with thrombosis and have an important role in the etiology of diseases such as stroke myocardial infarction whose etiologies were based on thrombosis. H. pylori has been proposed to be responsible for pathophysiology some including stroke, infarction, thrombosis, autoimmune diseases. From this point view, we hypothesized a possible relationship between infection aCL initially aimed determine prevalence antibody positivity children...
Hemoglobin M Saskatoon (s63 His>Tyr(C-T)) is a rare hemoglobin variant that was first reported in Japan, followed by the US, Indonesia, Algeria, Russia, India, and Germany [1-8]. It also combination with another variant—Hb Hamilton [9]; however, it has yet to Turkish population [10,11]. The present report describes observation of this an 9-year-old Iraqi boy presented fatigue greyblue discoloration distal extremities mucous membranes since birth. Physical examination showed cyanosis clubbing...
Folate metabolic pathway plays a significant role in leukemogenesis because of its necessity for nucleotide synthesis and DNA methylation. deficiency causes damage. Thus polymorphisms folate-related genes may affect the susceptibility to childhood Acute Lymphoblastic Leukemia (ALL). MTHFR (Methylenetetrahydrofolate Reductase), DHFR (Dihydrofolate reductase), CBS (Cystathionine β-synthase) TYMS (Thymidylate Synthase) have an important folate their activated variants modulate levels folate. In...
Akın DF, Aşlar-Öner D, Kürekçi E, Akar N. Frequency of thiopurine S-methyltransferase gene variations in Turkish children with acute leukemia. Turk J Pediatr 2018; 60: 147-152. In this study we aim to determine the genotype distribution and allele frequencies common TPMT (*2, *3A, *3B *3C) polymorphisms The population consisted 169 patients aged between 1 15 years who were admitted Losante Pediatric Hematology Children`s Hospital diagnosis Genotyping was screened real-time PCR using...
Background/Aims: As a source of hematopoietic stem cells, peripheral blood cells have been used more frequently in both malignant and non-malignant diseases. There are some difficulties the collection PBSC from children compared to adults such as vascular access and, extracorporeal circuit volume, especially small children. Methods: In this study, we present our experience 63 who underwent cell transplantation between November 2016 September 2023. Results: The median age weight at time...
B-ALL is the most common subtype of childhood Acute Lymphoblastic Leukemia (ALL), affecting approximately 85% children worldwide. Minimal Residual Disease (MRD) monitoring during treatment ALL important for prognosis disease. MRD monitoring, which enables early detection relapse, determination risk percentage and understanding effectiveness treatment, can be performed with multiple methods such as flow cytometry, qRT-PCR NGS. Asparaginase an enzyme that has been used in since 1960s,...
This study aimed to determine whether there are commonly occurring hematologic causes that may lead thrombosis in patients recently diagnosed with immunoglobulin A vasculitis (IgAV). The prospective enrolled 107 pediatric IgAV and 98 healthy age- sex-matched controls. Patients who were treated at a single center between February 2016 June 2022 evaluated for the prevalence clinical relevance of thrombophilic gene mutations other prothrombotic risk factors, as well coagulation test indices....
Although childhood acute lymphoblastic leukemias are of good prognosis than adulthood, some chromosomal abnormalities may have negative effects on their prognosis. Inverted duplication (1q) is a abnormality with effect outcome Burkitt leukemia and lymphomas. We report case CD20+ inverted mutation, who had an early relapse during NHL-BFM 95 treatment. Two courses ICE-rituximab treatment were administered after successful HLA-full match bone marrow transplantation was carried out. He in...