A5091765808- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Hemoglobinopathies and Related Disorders
- Renal Transplantation Outcomes and Treatments
- Immune Cell Function and Interaction
- Chronic Lymphocytic Leukemia Research
- Lysosomal Storage Disorders Research
- Trypanosoma species research and implications
- Neurological Complications and Syndromes
- Immunodeficiency and Autoimmune Disorders
- COVID-19 Clinical Research Studies
- Childhood Cancer Survivors' Quality of Life
- CAR-T cell therapy research
- Polyomavirus and related diseases
- Adolescent and Pediatric Healthcare
- Sepsis Diagnosis and Treatment
- Metabolism and Genetic Disorders
- Peroxisome Proliferator-Activated Receptors
- Autoimmune and Inflammatory Disorders Research
- Lymphoma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Long-Term Effects of COVID-19
- Antibiotic Resistance in Bacteria
- Bone and Joint Diseases
Bahçeşehir University
2021-2025
Marmara University
2024
Antalya IVF
2024
Ark Medical Center
2023
Istanbul Eye Hospital
2020-2021
Despite the increasing performance of allogeneic hematopoietic cell transplantation over last decades, graft-versus-host disease (GVHD) remains main cause morbidity and mortality. The efficacy ruxolitinib against GVHD has been demonstrated in adult studies; however, very few studies have conducted children.This study aimed to evaluate 29 children with steroid-refractory acute or chronic GVHD. Twenty-five (87%) patients received at least three different immune modulator agents, including...
It is uncertain whether hematopoietic stem cell transplantation (HSCT), versus standard enzyme replacement therapy (ERT), effective for type VI mucopolysaccharidosis (MPS VI). New related advances in HSCT prompted an examination of the transplant procedures performed a recent cohort. This single-center retrospective study reviewed medical records 17 pediatric patients with MPS who underwent allogeneic 2021-2023. All conditioning regimens were myeloablative. Engraftment days, complications,...
Background: Total body irradiation (TBI) is the cornerstone of conditioning regimens in pediatric hematopoietic stem cell transplantation for acute lymphoblastic leukemia. As late effects and survival comparison between TBI chemotherapy were well analyzed before, this study, we aim to focus on first 100 days early complications transplantation. Methods: This retrospective study involves 72 patients (0 18 y) underwent leukemia October 2015 May 2019. Patients are divided into 2 groups...
ALD is a rare X-linked peroxisomal metabolic disorder with many distinct phenotypes of disease that emerge on wide scale from adrenal insufficiency to fatal cALD which progresses vegetative state within few years. Currently, HSCT the only treatment method known stabilize progression in patients cALD. In this study, we aim report our experience and factors determine success HSCT, as single-center experience.The study cohort involves 23 boys three trait new-onset abnormal behavior who...
Graft-versus-host disease (GvHD) is one of the leading causes morbidity and mortality in patients undergoing allogeneic HSCT, effective prevention GvHD critical for success HSCT procedure. Calcineurin inhibitors (CNI) have been used decades as backbone prophylaxis. In this study, efficacy safety Cyclosporine A (CsA) tacrolimus (TCR) were compared pediatric thalassemia.
Data on the risk factors and outcomes for pediatric patients with SARS-CoV-2 infection (COVID-19) following hematopoietic stem cell transplantation (HSCT) are limited. The study aimed to analyze clinical signs, factors, ICU admission mortality in a large cohort who underwent allogeneic HSCT prior COVID-19 infection. In this nationwide study, we retrospectively reviewed data of 184 recipients had between March 2020 August 2022. median time from was 209.0 days (IQR, 111.7-340.8; range, 0-3845...
<title>Abstract</title> Mucopolysaccharidosis IVA (MPS IVA; Morquio syndrome) is a lysosomal storage disorder and features systemic skeletal dysplasia that caused by defective Nacetylgalactosamine-6-sulfate sulfatase (GALNS). Although there are convincing data for hematopoietic stem cell transplantation (HSCT) in certain types of MPS, the studies limited MPS more still pending to show efficacy/safety HSCT. This study included 3 girls 7 boys with who underwent allogeneic HSCT between February...
Germline pathogenic variants (PVs) in CBL is found 15% of juvenile myelomonocytic leukemia (JMML) cases. Here we report siblings with variations presenting a heterogenous JMML clinic and outcome. The index case was diagnosed at the age seven, whereas younger brother 10 months old youngest one month old. hematopoietic stem cell transplantation successful for event free survival, but middle showed severe graft versus host disease. This study shows heterogeneity how outcome might differ even...
Background. Ralstonia pickettii is an aerobic Gram-negative non-fermentative bacillus. It opportunistic pathogen that has recently prompted nosocomial outbreaks. Although it low virulence, can cause a wide range of invasive diseases in immunosuppressive patients. The characteristics R. pickettii-related central line-associated bloodstream infection (CLABSI) outbreak pediatric hematopoietic stem cell transplant (HSCT) recipients are presented this study. Materials and Methods. This was...
Abstract Objective The selection of graft‐vs. ‐host disease (GvHD) prophylaxis is vital for the success hematopoetic stem cell transplantation (HSCT), and calcineurin inhibitors (CNI) have been used decades as backbone GvHD prophylaxis. aim this study to analyze results switching cyclosporine (CSA) tacrolimus because acute GvHD, engraftment syndrome (ES), persistent low level CSA, or various CSA‐associated adverse events in first 100 days pediatric HSCT. Materials Methods This a...
Abstract Although advancements have been made in monitoring and preventing viral infections HSCT patients, CMV reactivation still remains a critical post‐transplant complication. Adoptive cell therapy is an alternative to pharmacotherapy of infection refractory patients. We retrospectively reviewed cases after allogeneic who received U‐DLI as treatment. In total, five pediatric patients between the ages 0.5‐16 years that for post‐HSCT were evaluated. The dose CD3+ lymphocytes administered...
The use of unmanipulated haploidentical hematopoietic stem cell transplantations (haplo-HSCT) with post-transplant cyclophosphamide (PTCY) in children has emerged as an acceptable alternative to the patients without a matched donor. However, timing calcineurin inhibitors (CNIs) used combination PTCY is increasingly becoming topic controversy.We evaluated 49 acute leukemia who underwent haplo-HSCT according initiation day CNIs (pre- or post-cyclophosphamide [CY]).There were no significant...
Background: Data on the outcome and risk factors of pediatric patients with SARS-CoV-2 infection (COVID-19) following hematopoietic stem cell transplantation (HSCT) are limited. Objectives: We aimed to describe for a severe course mortality. Method: In this nationwide study, data were collected retrospectively from 28 transplant centers. Results: One hundred ninety-six children [(63.8% male; median age 8.75 (IQR, 4.86-14.30)] who received allogeneic (n: 184, 93.9%) or autologous 12, 6.1%)...
Amaç: Günümüzde talasemi majör (TM) hastalarında en önemli sorun transfüzyonların neden olduğu demir yükü ve bunun doğurduğu komplikasyonlardır.Bu durumun günümüzde kabul edilen tek küratif tedavi seçeneği hematopoetik kök hücre nakli (HKHN)'dir.Çalışmamızda, TM nedeniyle akraba dışı donörden merkezimizde HKHN uygulanmış hastalarımızın uzun dönem sağkalım sonuçları kronik graft versus
Amaç: Aralık 2019'dan beri, Dünya Sağlık Örgütü (DSÖ) tarafından koronavirüs hastalığı-2019 (COVID-19) olarak adlandırılan COVID-19 pandemisi tüm dünyayı etkilediği gibi hematolojik uygulamaları da etkilemektedir.COVID-19'un yaşlılarda, altta yatan kronik hastalığı olanlarda
Background: For the prophylaxis of graft versus host disease (GVHD), calcineurin inhibitors are backbone therapy and cyclosporine is preferred more frequently than tacrolimus in pediatric hematopoietic stem cell transplantation. However, although use has increased recently, number studies comparing these two drugs patient group limited. Aims: In this study, efficacy safety were compared patients transplanted for thalassemia. Methods: 129 who underwent transplantation with diagnosis...