A5021607253- Cutaneous lymphoproliferative disorders research
- Childhood Cancer Survivors' Quality of Life
- CAR-T cell therapy research
- Fungal Infections and Studies
- Lymphoma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Retinopathy of Prematurity Studies
- Palliative Care and End-of-Life Issues
- COVID-19 and healthcare impacts
- Viral-associated cancers and disorders
- COVID-19 Clinical Research Studies
- Neutropenia and Cancer Infections
- Chronic Lymphocytic Leukemia Research
- Hematological disorders and diagnostics
- Vascular Malformations and Hemangiomas
- Cerebral Venous Sinus Thrombosis
- Ocular Diseases and Behçet’s Syndrome
- Blood disorders and treatments
- Cancer Treatment and Pharmacology
- Neonatal Health and Biochemistry
- Blood transfusion and management
- Cardiac tumors and thrombi
- Lymphadenopathy Diagnosis and Analysis
- Tuberous Sclerosis Complex Research
- CNS Lymphoma Diagnosis and Treatment
Ümraniye Eğitim ve Araştırma Hastanesi
2021-2025
Sağlık Bilimleri Üniversitesi
2021-2025
Hospital Universitario Infanta Leonor
2023
University of Health Sciences
2023
Turkish Society of Hematology
2023
Hacettepe University Hospital
2021
Palmetto Hematology Oncology
2020
Gazi University
2012-2016
Although infantile fibrosarcoma accounts for less than 1% of all childhood cancers, it is one the most common non-rhabdomyomatous soft tissue tumours, mostly seen in first 2 years life, with an estimated incidence 5 1 000 infants [1-3]. They are typically locally aggressive, single, rapidly growing tumours. MRI and/or CT important diagnosis, pathological demonstration proliferation fibroblasts gold standard. In 85% fibrosarcomas, associated ETV6-NTRK3 gene fusion resulting from...
Vincristine is a widely used chemotherapeutic agent in the treatment of childhood malignancies. Neuropathy most common adverse effect. CYP3A4 and CYP3A5 enzymes cytochrome p450 enzyme system are responsible vincristine metabolism. Genetic polymorphism may alter metabolism neurotoxicity rate. In this study, distribution alleles among Turkish children with malignancies, relation between genotype rates, as well severity duration neuropathy total doses were investigated. Patient group consisted...
: In childhood cancers, parents are affected psychologically as well children. We aimed to evaluate the effect of cancer type and stage, elapsed time from diagnosis, on anxiety stress indicators among parents.
The lockdown precautions during the COVID-19 pandemic led to concerns about delayed diagnosis of malignancies. This study aimed compare duration complaints at home and presence metastasis pre-pandemic period in children with cancer.All diagnosed cancer followed up our clinic between 2017 2022 were included. Patients a acute/chronic leukemia excluded. Age, gender, type, complaints, recorded. compared statistically before after March 11, 2020, start point country.A total 161 patients analyzed...
Data on the risk factors and outcomes for pediatric patients with SARS-CoV-2 infection (COVID-19) following hematopoietic stem cell transplantation (HSCT) are limited. The study aimed to analyze clinical signs, factors, ICU admission mortality in a large cohort who underwent allogeneic HSCT prior COVID-19 infection. In this nationwide study, we retrospectively reviewed data of 184 recipients had between March 2020 August 2022. median time from was 209.0 days (IQR, 111.7-340.8; range, 0-3845...
The hypereosinophilic syndromes (HES) are characterized by prolonged nonreactive peripheral blood hypereosinophilia with tissue damage. lymphocytic HES variant can precede malignant clonal T-cell disease in adults but it is extremely rare to be the presenting feature of lymphomas children. Here we present a 2.5-year-old boy and mediastinal anaplastic lymphoma kinase (ALK) negative systemic large-cell lymphoma. Mature immature eosinophils without blasts were shown on bone marrow aspiration...
In childhood acute lymphoblastic leukemia (ALL), very promising results were obtained thanks to the developments in treatment strategies recent years. However, complications during continue be important causes of mortality and morbidity. this study, that develop ALL evaluated.Medical records 47 patients treated according (ALL Intercontinental Berlin-Frankfurt-Münster) 2009 protocol between 2016 2021 evaluated retrospectively.Of patients, 28 (59.6%) male 19 (40.4%) female. The mean age at...
The association of Wilms tumor (WT) and vertebral disorders, such as hemivertebrae or fusion anomalies, have been described in literature. Here, we report a rare butterfly T3, T8 vertebrae T2, T7 patient with WT, determined during initial examinations tumoral extension. In patients investigation malformations should be part diagnostic work-up.
Graft versus host disease (GVHD) is an immunological complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Intensity conditioning, HLA and sex mismatch, older donor age lack GVHD prophylaxis are the well known risk factors development. In a recent study Giver et al showed that number red blood (RBC) transfusions during 30 days posttransplant also correlate with severity acute GVHD. Apart from nearly standard regimen by methotrexate cyclosporine combination, aGVHD...
Thymus gland involvement in Langerhans cell histiocytosis (LCH) is usually part of multi-system disease and may be more common than previously recognized. However, thymic causing an anterior mediastinal mass extremely rare presentation multisystem LCH. Here we report a 2-month-old-boy admitted to hospital with giant LCH involving the thymus, lungs, liver skin. The differential diagnosis children should also include LCH, especially disease. kept mind skin lesions infants, even if spontaneous...
Our objective in this study was to assess the association between eNOS gene, that achieves synthesis of nitric oxide especially endothelial cells known have an important role angiogenesis and vasculogenesis, G894T, intron 4 VNTR (27-bp repeat) T786C functional polymorphisms retinopathy prematurity (ROP), which is cause morbidity premature or low birth weight babies.A total 139 babies who were followed up our neonatal intensive care unit because hospital admitted unit. 69 them had comprised...
Blood transfusion is life-saving medical practice with significant risks. National and international guidelines have been established for indications related to blood use threshold values transfusions. In this study, we aimed determine the erythrocyte thrombocyte rates in surgical, internal, emergency clinics our hospital compare before platelet (PLT) among clinics.Red cell (RBC) PLT transfusions between January 2019 June were retrospectively analyzed. Clinics divided into three groups:...
Survival is low in recurrent or refractory Hodgkin Lymphoma (HL) patients. The aim of this study to evaluate the characteristics and outcomes relapsed HL patients our institution.
Objective: We aimed to evaluate the role of FDG-PET/CT in diagnosis, staging and response therapy during follow-up children adolescents with Hodgkin Lymphoma compare them conventional imaging techniques.
Background: Data on the outcome and risk factors of pediatric patients with SARS-CoV-2 infection (COVID-19) following hematopoietic stem cell transplantation (HSCT) are limited. Objectives: We aimed to describe for a severe course mortality. Method: In this nationwide study, data were collected retrospectively from 28 transplant centers. Results: One hundred ninety-six children [(63.8% male; median age 8.75 (IQR, 4.86-14.30)] who received allogeneic (n: 184, 93.9%) or autologous 12, 6.1%)...
Congenital thrombotic thrombocytopenic purpura is a rare, life-threatening disease with relapsing thrombocytopenia episodes accompanied by less prominent hemolytic anemia.Here we report 9-year-old Turkish boy congenital TTP homozygosity for the ADAMTS-13 gene p.Pro671Leu (c.2012C>T) mutation.He had recurrent of thrombocytopenia, diagnosed as chronic immune purpura, and treated IVIG steroids.After he was TTP, has been given fresh frozen plasma every three to four weeks, in good clinical...
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a newly identified, very rare, highly aggressive hematopoietic neoplasm, primarily found in elderly males. They typically present the form of skin involvement with high frequency lymph node and bone marrow involvement. BPDCN has poor prognosis, no consensus on widely accepted treatment modality. Here we young patient BPDCN, who presented generalized lymphadenopathy, involvement, leukemic blasts marrow. She was treated high-risk acute...