A5069240571- Acute Lymphoblastic Leukemia research
- Neutropenia and Cancer Infections
- Blood properties and coagulation
- Hematopoietic Stem Cell Transplantation
- Childhood Cancer Survivors' Quality of Life
- COVID-19 Clinical Research Studies
- Inflammatory Biomarkers in Disease Prognosis
- Blood Coagulation and Thrombosis Mechanisms
- Hemoglobinopathies and Related Disorders
- Acute Myeloid Leukemia Research
- Blood disorders and treatments
- Iron Metabolism and Disorders
- Platelet Disorders and Treatments
- Vascular Malformations and Hemangiomas
- Education Practices and Challenges
- Problem Solving Skills Development
- Venous Thromboembolism Diagnosis and Management
- Blood groups and transfusion
- Hematological disorders and diagnostics
- Respiratory viral infections research
- Erythropoietin and Anemia Treatment
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Antifungal resistance and susceptibility
- Autoimmune and Inflammatory Disorders Research
- Streptococcal Infections and Treatments
Afyonkarahisar Sağlık Bilimleri Üniversitesi
2021-2024
Afyon Kocatepe University
2021-2024
University of Health Science
2024
Sağlık Bilimleri Üniversitesi
2023-2024
Palmetto Hematology Oncology
2023
Eskişehir Osmangazi University
2016-2023
Shendi University
2023
Universidad CES
2021-2023
Erzurum Regional Training and Research Hospital
2020-2021
Adli Tıp Kurumu
2021
Objectives: The aim of this study is to identify the epidemiological, clinical, and laboratory features coronavirus disease 2019 (COVID-19) in children. Methods: A retrospective was conducted by pediatric infectious specialists from 32 different hospitals all over Turkey case record forms. Pediatric cases who were diagnosed as COVID-19 between March 16, 2020, June 15, 2020 included. Case characteristics including age, sex, dates onset diagnosis, family, contact information recorded. Clinical...
Introduction: The most common causes of microcytic anemia are iron deficiency (IDA) and thalassemia trait (TT). This study investigated the reliability erythrocyte indices formulas as screening tests in differential diagnosis IDA TT before performing detailed for definitive diagnosis. Materials Methods: In total, 50 children with β-TT, 31 α-TT, were included. For 8 (red blood cells [RBC], red cell distribution width [RDW], index [RDWI], Mentzer [MI], Shine Lal [S&L], England Fraser...
Objective: Iron deficiency anemia (IDA) has been demonstrated to be a risk factor for thromboembolic events, although the pathogenesis of development thromboembolism in IDA is as yet unclear. The likelihood children with contracting hypercoagulability was evaluated this cross-sectional study using rotational thromboelastometry (ROTEM).Material and Method: A total 57 (median age 11 years; 37 female, 20 male) 48 healthy 9.9 23 25 were enrolled study. Whole blood count, serum iron, transferrin...
Febrile neutropenia is an important cause of mortality and morbidity in hematology-oncology patients undergoing chemotherapy. The objective this study was to evaluate febrile neutropenic episodes children with malignancy.Sixty-eight who received chemotherapy for malignancy between 2010 2015 were retrospectively reviewed. demographic characteristics, laboratory data, infection foci, frequency microorganisms grown culture examined. Also, the attacks investigated according periods.Of total 200...
Henoch-Schönlein purpura is the most common vasculitis of childhood. This study investigated values hematologic indices that can help predict internal organ involvement. The included 112 patients followed up between January 2007 and May 2017 81 healthy children. Leukocyte, neutrophil, monocyte, lymphocyte platelet counts, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), C-reactive protein (CRP) levels were compared with without Overall, 57 (50.8%) had monocyte NLR, CRP...
Intensive chemotherapy can cause long-lasting immunosuppression in children who survived cancer. The varies according to the type of cancer, intensity and age patient. A sufficient immune reconstruction when has been completed childhood cancer survivors, re-vaccination program achieve antibody levels for some life-threatening vaccine-preventable infectious diseases. This study evaluates serological status pediatric acute lymphoblastic leukemia (ALL) cases before after intensive treatment....
Methotrexate (MTX) is a chemotherapeutic agent that functions as folic acid antagonist. The frequency of high dose methotrexate (HDMTX)-associated toxicity variable. In this study, we investigated the myelotoxicity and hepatotoxicity 7 days after HDMTX infusion.This study included children diagnosed with acute lymphoblastic leukemia (ALL) between January 2010 April 2015. patient blood counts biochemical parameters measured before infusion were retrospectively recorded. We assessed infusions...
Infantile hemangioma (IH) is the most common form of benign childhood vascular tumor. Most resolve spontaneously, but treatment recommended in patients who develop complication. Propranolol as first-line therapy, while case non-response to therapy depends on clinical experiences each center. The aim this study was investigate efficacy low-dose propranolol IH, and outcomes percutaneous intralesional bleomycin injection (IBI) unresponsive propranolol.Medical records 104 children diagnosed with...
Infantile hepatic hemangioendothelioma (IHHE) is the most common benign vascular liver tumor and typically occurs during first 6 months of life. A 4-month-old male patient presented with abdominal distention. physical examination revealed massive hepatomegaly. Liver enzyme levels were normal. The alpha fetoprotein level was 1,323 mg/dL (6-1,000). Abdominal magnetic resonance imaging (MRI) showed multiple, well-defined hyperintense nodular lesions in liver. MRI findings suggested IHHE....
Hemophagocytic lymphohystiocytosis (HLH) is characterized by fever, splenomegaly, pancytopenia, and elevated levels of triglycerides ferritin. These signs symptoms are common to other metabolic diseases.A 5-month-old female infant, who presented with respiratory distress, massive hepatomegaly, bicytopenia, was diagnosed as having HLH chemotherapy initiated. The patient negative for familial gene mutations. Respiratory distress laboratory findings improved rapidly after starting chemotherapy....
The present study investigates the predictive value of procalcitonin (PCT), C-reactive protein (CRP), presepsin (PRE-SEP) and soluble-triggering receptor, as expressed on myeloid cells (sTREM-1) levels in bloodstream infections pediatric patients with febrile neutropenia. A total 47 episodes neutropenia that developed 30 children malignancy were analyzed this study, while control group comprised 27 who had undergone chemotherapy for (completed ≥2 years ago) without neutropenia, fever or drug...
Cerebral sinovenous thrombosis (CSVT) in children is a rare and life-threatening cerebrovascular disease. Hence, we evaluated its clinical presentations, inherited acquired prothrombotic risk factors along with the accompanying diseases, locations as well outcomes of anticoagulant therapy CSVT.The medical records pediatric CSVT patients treated between January 2011 September 2018 were analyzed retrospectively.The study included 29 children, 15 boys (51.7%) 14 girls (48.3%), median age being...
Saprochaete capitata (S. capitata) is a very rare fungal pathogen that causes disseminated opportunistic infections in patients with hematologic malignancies. Fever resistant to broad-spectrum antibiotic and antifungal treatment common the presence of fungemia during period profound neutropenia. We describe three cases leukemic children who died from S. following first febrile neutropenic episode after induction chemotherapy. an emergent infection associated high mortality low susceptibility...
The most common childhood cancer is acute lymphoblastic leukemia (ALL).Chemotherapy-associated hematological toxicity well-known; however, there are few studies on hematologic incidence in children with ALL.We investigated the severity and of during intense chemotherapy processes treated ALL IC-BFM 2009 protocol.The study included 41 leukemic standard (SR) intermediate risk (IR) groups between 2011 2015.During induction period, grade 4 neutrophil count was 60%; ≥ 3 hemoglobin level 34%;...
Metabolic syndrome (MetS) and obesity have increasingly been reported in survivors of childhood cancer. Osteopontin (OPN) is primarily synthesized adipose tissue thought to a role the development insulin resistance (IR). The aim this study was investigate frequency MetS acute lymphoblastic leukemia (ALL) establish relationship between serum OPN levels anthropometric measurements glucose metabolism.A total 50 ALL (median age: 10.5 years; post-treatment interval 4.54 ± 2.48 years), 20 healthy...
: The Bernard-Soulier syndrome (BSS) is a rare disease with prevalence of 1/1000 000; it characterized by macrothrombocytopenia. BSS develops as result defect in the glycoprotein GPIb-IX-V complex on platelet surface. In this article, we present pediatric patient novel mutation that has been identified for first time BSS. A 13-month-old male was admitted severe thrombocytopenia unresponsive to intravenous immunoglobulin neonatal period and recurrent mucocutaneous bleeding which initiated at...
Abstract Objectives This study investigated the diagnostic power of reticulocyte hemoglobin equivalent (Ret-He) in differential diagnosis hypochromic microcytic anemia to differentiate iron deficiency (IDA) and thalassemia trait (TT) based on traditionally used erythrocyte index formulas. Methods Twenty-six children with (ID), 26 IDA, 33 β-TT, 41 healthy were assessed. Complete blood count parameters, Ret-He, immature fraction (IRF), low-fluorescence ratio (LFR), Mentzer’s indexes (MI)...
Objective Transfusion of blood and components is a special type tissue transplantation, life-saving treatment. However, besides the benefits product transfusions, there are also some undesirable side effects. In present study, frequency transfusion reactions related to were investigated. Methods this retrospective types time occurrence acute reaction (ATR), used in our hospital between January 2018 2020 evaluated for hemovigilance using unit products application effect reporting forms....
MicroRNAs have the potential to regulate systemic and cellular iron homeostasis at multiple points. In deficiency anemia (IDA), hypoxia, platelet reactivity, potentially microRNAs play a role in development of hypercoagulability. A total 57 children diagnosed with IDA between October 2016 2017 48 healthy were included this cross-sectional study. Blood count parameters, serum iron, transferrin saturation, ferritin level, maximum clot firmness (MCF), formation time index, which are indicators...
Aim: Acute rheumatic fever (ARF) is the most common cause of acquired heart disease especially in developing countries.This study intended to evaluate relationship between severity cardiac involvement and hematological parameters children diagnosed with carditis at first episode ARF.Methods: In this study, 45 ARF 30 healthy same age gender, September 2015 February 2019, were retrospectively reviewed.The data patients recorded from hospital automation system.Patients acute (ARC) grouped into...
Abs tractAim: Idiopathic peripheral facial paralysis [Bell's palsy (BP)] is the most common cause of acute, one-sided paralysis, whose etiopathogenesis currently unknown.However, inflammation considered to play a role in etiopathogenesis.In this study, we examined relationship between hematologic parameters and indices children with BP. Methods:The study included 60 pediatric patients diagnosed BP December 2017 May 2022 healthy controls same age gender.The patient control cohorts severity...
Data on the risk factors and outcomes for pediatric patients with SARS-CoV-2 infection (COVID-19) following hematopoietic stem cell transplantation (HSCT) are limited. The study aimed to analyze clinical signs, factors, ICU admission mortality in a large cohort who underwent allogeneic HSCT prior COVID-19 infection. In this nationwide study, we retrospectively reviewed data of 184 recipients had between March 2020 August 2022. median time from was 209.0 days (IQR, 111.7-340.8; range, 0-3845...
<title>Abstract</title> Introduction: Social responsibility projects have a prominent place in the education of Faculty Medicine. There are many different models social literature. It has been determined that most appropriate project model for needs medical is 'CARE' model, which stands Clinical Activities, Advocacy, Research, and Education. Therefore, designed implemented form clinical activities students communicate face-to-face with patients may contribute positively to students' thoughts...
Objectives: Our aim in this study is to investigate the effect of fibrosis at diagnosis on treatment and survival childhood acute lymphoblastic leukemia (ALL). Methods: This retrospective. We evaluated relationship between patients' age, white blood cell count diagnosis, morphological blast percentage flow cytometric day 15th 33th, absolute peripheral smear 8th, degree bone marrow biopsy 36 pediatric patients. The thirty-third after induction therapy was measured. Results: Twenty-eight...