A5055158302- Hemoglobinopathies and Related Disorders
- Immunodeficiency and Autoimmune Disorders
- COVID-19 Clinical Research Studies
- Blood groups and transfusion
- COVID-19 and healthcare impacts
- Blood disorders and treatments
- Neutropenia and Cancer Infections
- Central Venous Catheters and Hemodialysis
- Venous Thromboembolism Diagnosis and Management
- Acute Lymphoblastic Leukemia research
- Platelet Disorders and Treatments
- Lymphoma Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Acute Myeloid Leukemia Research
- Infective Endocarditis Diagnosis and Management
- Blood Coagulation and Thrombosis Mechanisms
- Vascular Tumors and Angiosarcomas
- Protein Tyrosine Phosphatases
- Neonatal Health and Biochemistry
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Vascular Anomalies and Treatments
- Lymphadenopathy Diagnosis and Analysis
- Autoimmune Neurological Disorders and Treatments
- Lymphatic System and Diseases
- Genomic variations and chromosomal abnormalities
Palmetto Hematology Oncology
2021-2024
Istanbul Medipol University
2023-2024
Sağlık Bilimleri Üniversitesi
2017-2024
Ege University
2023
Children's Hospital
2012-2022
University of Health Science
2022
University of Health Sciences
2022
Dr. Behçet Uz Çocuk Hastalıkları Hastanesi
2021
İstanbul Kanuni Sultan Süleyman Eğitim ve Araştırma Hastanesi
2017-2021
Izmir University
2021
Autoimmune cytopenias are a heterogeneous group of disorders characterized by immune-mediated destruction haematopoietic cell lines. Effective and well-tolerated treatment options for relapsed-refractory immune limited. In this study, the aim was to evaluate efficacy safety sirolimus in disease within paediatric age group. The study enrolled patients who used with diagnosis cytopenia between December 2010 2020, followed at six centres Turkey. Of 17 patients, five (29.4%) were treated...
Thrombocytopenia is a common clinical problem in cancer patients undergoing high-dose chemotherapy and autologous hematopoietic stem cell transplantation (HSCT). It can occur as prolonged isolated thrombocytopenia (PIT) or secondary failure of platelet recovery (SFPR) may cause potentially fatal bleeding. However, data on the treatment post-transplant still lacking.
Objective: It is well known that increased oxidative stress leads to tissue damage in beta-thalassemia (β-thal) patients. Thiols are one of the most important antioxidant agents, and thiol/disulfide (SH/SS) homeostasis a novel marker. This study aimed investigate relationship thiol levels, SH/SS homeostasis, ischemia-modified albumin (IMA) patients with β-thal. Materials Methods: A hundred transfusion-dependent β-thal 41 healthy controls were included study. Results: Native thiol, total...
Background: Candidemia and Candida -associated catheter-related bloodstream infections (CRBSIs) are the significant cause of mortality morbidity in patients with malignancy. Methods: A retrospective analysis including all pediatric hematologic/oncologic malignancies CRBSIs treated Dr. Behçet Uz Children Diseases Surgery Training Research Hospital between period 2009 2020. Results: During study period, 53 children associated species were included. The most common malignancy was acute...
Introduction: Ewing sarcoma (ES) is a rare, aggressive, malignant tumor.It the second most common bone tumor in children.A total of 20-25% patients are metastatic at time diagnosis.The survival rate for localized disease (LD) approximately 70-74%.For (MD), it about 30%.The important prognostic factor affecting presence MD diagnosis.In this study, we investigated clinical characteristics, treatment outcome, and factors prognosis followed up with diagnosis ES. Materials Methods: Between 2007...
Hepatic hemangiomas (HH) are the most common vascular tumors of liver. It is important to distinguish from malignant liver tumors.The patients 0 1 years old, were diagnosed with HH and followed up in oncology outpatient clinic between 2009 2020 included study.A total 127 diagnosis study. Of patients, 99 (78%) had focal, 20 (15.7%) multifocal, 8 (6.3%) diffuse HHs. Surgery was performed confirmed histopathologically 6 (4.7%). During follow-up, 16 (12.5%) received medical treatment. Thirteen...
Lymphomas are solid tumors characterized by the malignant proliferation of lymphoid cells. Neurologic signs encountered in patients with Hodgkin's lymphoma can be due to direct spread tumor nervous system, secondary chemotherapy or radiation, mass compression, infectious causes and paraneoplastic syndromes. Paraneoplastic neurologic syndromes rarely non-Hodgkin's lymphoma. Except for cerebellar degeneration dermato/polymyositis both lymphoma, other uncommon have only been reported as...
Abstract Hydrothorax of the cerebrospinal fluid after a subarachnoid‐pleural fistula is rare condition. Subarachnoid‐pleural may appear trauma at thoracolumbar vertebral column or iatrogenically thoracotomy. A two years and four months old boy who was operated because ganglioneuroblastoma admitted to hospital due respiratory distress. The chest roentgenogram obtained thoracotomy, showed pleural effusion left side tube inserted. craniospinal magnetic resonance imagining revealed lumbar...
This study was organized to determine the efficacy and safety of deferasirox (DFX) in reducing SF patients with transfusion-dependent thalassemia (TDT). is a retrospective, descriptive 101 transfusion- dependent major who were followed for 48 months. Twenty-nine used an alternative chelator either alone or combined, not compliant treatment, changed drug due adverse reactions, had multiple transfusions did complete 4 years DFX use excluded. A total 72 out completed study. decreases noted 6-12...
Data on the risk factors and outcomes for pediatric patients with SARS-CoV-2 infection (COVID-19) following hematopoietic stem cell transplantation (HSCT) are limited. The study aimed to analyze clinical signs, factors, ICU admission mortality in a large cohort who underwent allogeneic HSCT prior COVID-19 infection. In this nationwide study, we retrospectively reviewed data of 184 recipients had between March 2020 August 2022. median time from was 209.0 days (IQR, 111.7-340.8; range, 0-3845...
Objective: Patients with Noonan syndrome (NS), who may need various surgical interventions throughout their lives, to be evaluated carefully in the preoperative period due risk of bleeding diathesis. There is a limited number studies evaluating diathesis patients NS. In this study, we aimed determine frequency NS and evaluate place thromboelastography (TEG) determining bleeding. Method: our score coagulation test results obtained from files 12 were evaluated. Results: The most frequently...
Hemoglobinopaties are the most common genetic disorder worldwide. Patients with transfusion-dependent thalassemia major (TDT) deficient in β-globulin chain production, resulting ineffective erytropoiesis and hemolysis. Consequently, patients TDT suffer from primary secondary iron overload, leading to severe organ dysfunction. In despite of significant improvements supportive care, especially monitoring treatment overload its complications, dysfunction progresses adulthood, morbidity...
The number of studies evaluating teicoplanin lock therapy in coagulase-negative staphylococcus-associated catheter infection pediatric malignancies is limited. aim this study was to evaluate the efficacy cancer cases. Twenty-two patients with totally implantable venous access device infection, who had undergone closure treatment, were included study. Demographic data, treatment days, and success data obtained from medical files patients. Fourteen (63.6%) acute lymphocytic leukemia, 3 (13.6%)...
This is the report of a 2-year-old boy who presented with fever, cytopenia, and splenomegaly. The patient was diagnosed hemophagocytic lymphohistiocytosis (HLH) treated HLH-2004 protocol. Repeated bone marrow aspiration showed amastigotes on follow-up. In endemic countries, visceral leishmaniasis should be considered in differential diagnosis to avoid chemotherapy toxicity.
The prevalence of intracardiac thrombus (ICT) is gradually increasing, though it rare among children. Data related to the occurrence ICT children are limited, and treatment recommendations have been made utilizing adult guidelines. primary objective this study determine associated factors, management, outcomes thrombosis in Between January 2013 2020, patients diagnosed with at Pediatric Hematology-Oncology Cardiology departments our hospital were included study. Demographic characteristics,...
invades surrounding structures such as the heart, lungs, pleura, and superior vena cava [1,2].Patients often present with cough, dyspnea, chest pain, syndrome [3].R-CHOP plus consolidative mediastinal radiation is an option [4].Herein, we report a rare case of asymptomatic PMBCL bulky mass in which patient achieved complete remission after R-CHOP radiation.
Objective: Renal involvement in systemic lupus erythematosus is an important cause of morbidity and mortality. Cyclophosphamide widely used the treatment nephritis. The aim this study to evaluate effectiveness intravenous cyclophosphamide children with Material Method: In study, 28 patients nephritis treated by pulse between years 1999, 2011 Istanbul Faculty Medicine, Department Pediatric Nephrology were investigated retrospectively. Clinical history, presenting symptoms findings, laboratory...
Autosomal recessive osteopetrosis is also known as infantile malignant (IMO). The clinical course often serious and if left untreated, it fatal in the 1st year of life. Diagnosis challenging delayed or misdiagnosed. Herein, we present an infant girl who was diagnosed with IMO during evaluations for her hypotonicity thrombocytopenia. A novel mutation chloride voltage-gated channel 7 (CLCN7) gene reported. 10-day-old female patient referred to our hospital evaluation hypotonicity. Her physical...
This study aimed to evaluate systemic thrombolysis experiences with recombinant tissue plasminogen activator (rtPA).Retrospective data were collected from 13 Turkish pediatric hematology centers. The dose and duration of rtPA treatment, concomitant anticoagulant complete clot resolution (CCR), partial (PCR), bleeding complications evaluated. Low-dose (LD) treatment was defined as 0.01-0.06 mg/kg/h high-dose (HD) 0.1-0.5 mg/kg/h.Between 2005 2019, 55 thrombotic episodes 54 patients a median...
Introduction Asparaginase is an indispensable drug in treating childhood acute lymphoblastic leukemia (ALL). Hypersensitivity reactions (HSR) are the most common side effects and interfere with antineoplastic activity of drug. This study aims to compare intramuscular (IM) intravenous (IV) administration routes Native Escherichia coli Lasparaginase (L-ASNase) terms hypersensitive reactions. Methods L-ASNase was randomly administered IV or IM newly diagnosed ALL patients HSR monitored all for...
Background: Data on the outcome and risk factors of pediatric patients with SARS-CoV-2 infection (COVID-19) following hematopoietic stem cell transplantation (HSCT) are limited. Objectives: We aimed to describe for a severe course mortality. Method: In this nationwide study, data were collected retrospectively from 28 transplant centers. Results: One hundred ninety-six children [(63.8% male; median age 8.75 (IQR, 4.86-14.30)] who received allogeneic (n: 184, 93.9%) or autologous 12, 6.1%)...