A5054503835- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Blood disorders and treatments
- Hematopoietic Stem Cell Transplantation
- Hemoglobinopathies and Related Disorders
- Platelet Disorders and Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Immunodeficiency and Autoimmune Disorders
- Hemophilia Treatment and Research
- Iron Metabolism and Disorders
- Neutropenia and Cancer Infections
- Sarcoma Diagnosis and Treatment
- Complement system in diseases
- Blood groups and transfusion
- Renal cell carcinoma treatment
- Prenatal Screening and Diagnostics
- Neurogenetic and Muscular Disorders Research
- Neonatal Health and Biochemistry
- Venous Thromboembolism Diagnosis and Management
- COVID-19 Clinical Research Studies
- Acute Myeloid Leukemia Research
- Neuroblastoma Research and Treatments
- Soft tissue tumor case studies
- Renal and related cancers
- Blood properties and coagulation
Eskişehir Osmangazi University
2004-2024
Eskişehir Osmangazi Üniversitesi Tıp Fakültesi Hastanesi
2019-2023
Eskişehir City Hospital
2021
Altınbaş University
2019-2021
Dr. Behçet Uz Çocuk Hastalıkları Hastanesi
2014-2020
Sağlık Bilimleri Üniversitesi
2019
Hematology\Oncology Clinic
2018
Balıkesir University
2018
Gaziosmanpaşa Taksim Eğitim ve Araştırma Hastanesi
2018
Izmir Tepecik Eğitim ve Araştırma Hastanesi
2017
Objective: The clinical impact of central line bundle programs for line–associated bloodstream infections has been well demonstrated in intensive care units. However, the experience totally implantable venous access devices (ports) pediatric-hematology patients was limited. Methods: A retrospective study designed to compare and evaluate implementing a 2-year 5-month period, including 10 months prebundle 11 (that includes needleless split-septum devices), finally 8 period which single-use...
Intensive chemotherapy can cause long-lasting immunosuppression in children who survived cancer. The varies according to the type of cancer, intensity and age patient. A sufficient immune reconstruction when has been completed childhood cancer survivors, re-vaccination program achieve antibody levels for some life-threatening vaccine-preventable infectious diseases. This study evaluates serological status pediatric acute lymphoblastic leukemia (ALL) cases before after intensive treatment....
Thalassemias are the most common monogenic disorders worldwide. Thalassemia patients experience difficulties in their schooling, finding jobs and/or marriage because of functional and physical limitations caused by this disease. It is expected that quality life (QoL) with thalassemia will be lower than those without The aim study was to benefit worldwide terms QoL mental health. This cross-sectional performed Turkey. population consisted 57 β-thalassemia major (β-TM) control group. short...
Immune thrombocytopenic purpura (ITP) results from accelerated platelet destruction mediated by autoantibodies to glycoproteins. Some patients with chronic ITP are refractory all therapies [steroids, intravenous immunoglobulin (IVIG), anti-D and immunosuppresive drugs] have low counts episodic bleeding. We retrospectively evaluated the efficacy safety of rituximab treatment splenectomy in paediatric diagnosed who were unresponsive steroids, IVIG, cyclosporine mycophenolate mofetil. Records...
Introduction: Inherited factor VII (FVII) deficiency is the most common of rare bleeding disorders and shows a heterogenous distribution phenotypes independent activity level. The score (BS) evaluates phenotype patients with disorders. Thromboelastography (TEG) thrombin generation assays (TGAs) are 2 methods to evaluate global hemostasis, controversially both tests useful for identifying different tendency phenotypes. purpose this study was investigate use BS (TEG TGAs) predict inherited...
The purpose of the study is to describe sleep habits, assess prevalence disturbances in pediatric cancer patients and healthy controls, compare patterns, problems. One hundred-thirty-five 190 controls were evaluated. Healthy children matched for age, sex, economic status, parental education family structure constituted control group. Sleep was evaluated by using Children`s Habits Questionnaire (CSHQ). problems detected half patients. There no significant differences total score subscale...
Abstract Background In patients with acute lymphoblastic leukemia (ALL), the risk of thromboembolism increases due to hemostatic changes secondary primary disease and treatment‐related factors. this multicenter study, we aimed research frequency central nervous system (CNS) thrombosis occurring during treatment, hereditary acquired factors, clinical laboratory features thrombosis, treatment approaches, thrombosis‐related mortality morbidity rates in pediatric ALL patients. Procedure...
Protein sentezinde, pek çok enzimin yapı ve işlevinde görev alır, hücre solunumunda, vücutta oksijen elektronların taşınmasında rol oynar (1).Bu nedenle, eksikliğinde sadece anemi değil diğer
Thymomas are the most common masses located in anterior mediastinum, and they often associated with autoimmune disorders including myasthenia gravis, polymyositis, aplastic anemia (AA). Autoreactive T-cell clones generated by thymoma may lead to disorders. We report case of a 14-year-old boy who was examined for AA, underlying cause determined be an immune-mediated complication thymoma. He had no matched sibling donors. underwent thymectomy, 3 months later he treated immunosuppressive...
Hepatitis-associated aplastic anemia (HAA) is a form of acquired (AA) in which bone marrow failure develops after an acute attack hepatitis. Bone leading to AA generally severe cases HAA and fatal if left untreated. This retrospective multicenter study investigated clinical laboratory characteristics, possible causes, treatment, outcome children. Twenty patients from 8 centers were included the study. Aspartate aminotransferase alanine <3 5×upper limit normal (ULN) 2 patients, <5 10×ULN...
Inhibitor development is the most frequent and serious complication of treatment in patients with hemophilia. Immune tolerance induction (ITI) only option for eradication factor VIII (FVIII) inhibitor. We would like to present our case hemophilia whose FVIII inhibitor was done by a low-dose ITI regimen. Our patient has been applied on-demand therapy until 8 years age. Secondary prophylaxis began because having hemophilic arthropathy. A low titer (4.2 BU/ml) detected fifth month prophylaxis....
Chronic neutropenia (CN) is defined as that persists for >3 months; it caused by a heterogeneous group of diseases in children. The aim the present study was to evaluate significance and clinical manifestations CN children at single children's hospital. Between October 2004 April 2014, patient data were evaluated retrospectively. Thirty-one patients assessed this study. Thirteen them (41.9%) younger than 12 months age initial diagnosis. There no difference absolute number neutrophils...
Abstract The complementation Q group (FANCQ) subtype of Fanconi anemia (FA) caused by the ERCC4/XPF mutation is very rare. Two siblings, aged 13 and 10 with phenotypic features, presented right hemiparesis focal‐onset seizures. In both cases, cranial magnetic resonance imaging (MRI) showed mass‐like lesions accompanied peripheral edema calcification. one case, oral steroid treatment surgical excision were performed, while in other lesion regressed just without surgery. Both siblings remained...
Data on the risk factors and outcomes for pediatric patients with SARS-CoV-2 infection (COVID-19) following hematopoietic stem cell transplantation (HSCT) are limited. The study aimed to analyze clinical signs, factors, ICU admission mortality in a large cohort who underwent allogeneic HSCT prior COVID-19 infection. In this nationwide study, we retrospectively reviewed data of 184 recipients had between March 2020 August 2022. median time from was 209.0 days (IQR, 111.7-340.8; range, 0-3845...
The improved survival rates of childhood cancers raise the long-term risk second primary malignancy (SPM) in and adolescent cancer survivors. intensity treatment protocol used, use some groups chemotherapeutics, radiotherapy were found to be factors for development malignancies (SPMs). Forty-one patients who developed acute myelocytic leukemia or any solid organ within 25 years follow-up, after completion pediatric lymphoblastic (ALL) treatment, included study. mean duration initial ALL...
Background. Microbiologic confirmation of respiratory tract infections gained importance during the coronavirus disease 2019 (COVID-19) pandemic. This study retrospectively evaluated seasonal distribution, clinical presentation, and complications viral (RVIs) other than COVID-19 in children with cancer after pandemic lockdown. Methods. Two hundred sixty-five inpatient outpatient RVI episodes 219 pediatric patients confirmed by multiplex reverse transcriptase polymerase chain reaction...
We report on a 12-year-old boy with congenital thrombotic thrombocytopenic purpura, who had an erroneous diagnosis as chronic immune thrombocytopenia. The patient presented complaints of jaundice and skin rash. Laboratory analysis showed nonimmune hemolytic anemia severe Peripheral blood smear 8% schistocytes, polychromasia, anisocytosis. ADAMTS13 antigen activity were suspected to be lower than 5% any antibodies against the enzyme. DNA sequence analyses resulted in compound heterozygosity...
Abstract Background Retinoblastoma (RB) is the most common intraocular malignancy in childhood. Advanced RB, associated with exceedingly poor prognosis, requires more intensive multiagent chemotherapy than conventional regimens. Rescue of bone marrow after achieved stem cell transplantation. The sequential courses (tandem transplantation) high‐dose followed by autologous transplantation allow for even greater dose intensity consolidation potential to use different active chemotherapeutics at...
Purpose: Invasive fungal infections are an important cause of morbidity and mortality in children with febrile neutropenia. Although liposomal amphotericin B (L-AMB) is used safely due to its broad antifungal activity, it causes side effects such as nephrotoxicity hypokalemia. Methods: Medical records 45 hematological malignancies who were given empirical L-AMB for neutropenia between November 2011 December 2019 reviewed retrospectively. The estimated glomerular filtration rate (eGFR), serum...
Allogeneic hematopoietic stem cell transplantation (HSCT) is the curative therapy for β-thalassemias that induces severe life-threatening complications. The human leukocyte antigen (HLA) registries and umbilical cord blood banks have carried out diligent searches to find matched unrelated donors (MUDs) about 70.0% of patients from 2000 onwards. chance finding a non-sibling fully family higher in some ethnic groups which consanguineous marriages are common. We studied compared transplant...
Abstract Background: Proper clinical use of blood products requires competent theoretical and practical knowledge transfusion medicine. In this study, we aimed to evaluate levels medicine attainment educational targets identify factors affecting the education Methods: A multicentric survey study was performed among final-year medical students. The questions were prepared based on learning objectives for curriculum. questionnaire focused safety administration. Results: included 727 (24%) 3009...