A5003503947- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Acute Lymphoblastic Leukemia research
- Neutropenia and Cancer Infections
- Childhood Cancer Survivors' Quality of Life
- Antifungal resistance and susceptibility
- Vascular Anomalies and Treatments
- Folate and B Vitamins Research
- Blood Coagulation and Thrombosis Mechanisms
- Neonatal Health and Biochemistry
- Congenital Diaphragmatic Hernia Studies
- Blood groups and transfusion
- Venous Thromboembolism Diagnosis and Management
- Immunodeficiency and Autoimmune Disorders
- Hematopoietic Stem Cell Transplantation
- Erythrocyte Function and Pathophysiology
- Platelet Disorders and Treatments
- Hematological disorders and diagnostics
- Food Allergy and Anaphylaxis Research
- Renal Diseases and Glomerulopathies
- Streptococcal Infections and Treatments
- Case Reports on Hematomas
- Vitamin K Research Studies
- Histiocytic Disorders and Treatments
- Viral-associated cancers and disorders
Memorial Ankara Hospital
2012-2024
Dr Sami Ulus Çocuk Sağlığı ve Hastalıkları Eğitim ve Araştırma Hastanesi
2011-2023
Ministry of Health
2014-2023
Sağlık Bilimleri Üniversitesi
2018-2023
University of Health Science
2023
University of Health Sciences
2023
Committee on Publication Ethics
2022
Health and Human Development (2HD) Research Network
2022
Ankara Onkoloji Eğitim ve Araştırma Hastanesi
2021
Erzurum Regional Training and Research Hospital
2016-2018
Venous thromboembolism (TE) and arterial TE are rare in children, but can cause severe morbidity mortality. The incidence of is 8.6-57 per 100 000 among hospitalized children 0.14-0.9 the general pediatric population. risk increased nephrotic syndrome (NS) patients. thromboembolic complications NS patients approximately 3%. Herein we report a patient that presented with massive bilateral pulmonary embolism (PE) whom underlying condition was NS. At onset clinical course findings were...
The endocrinological complications in β-thalassemia major patients do affect the life quality to a large extend. In this study, of 47 patients, who have been followed-up at our hospital's pediatric hematology department, were evaluated. Out cases included 55.3% was male and 44.7% female. patients' mean levels ferritin, whose age 10.0 ± 4.5 years (2–20 years), 2497 1469 ng/mL (472–8558 ng/mL). At least one pathology 27 out (57.4%) more than 14 (29.7%) thalassemia observed. most frequently...
Abstract Background Kawasaki disease (KD) may cause cardiac and coronary complications. Since definite markers to accurately predict involvement is not present, we aimed analyze the role of hematological indices [neutrophil-to lymphocyte ratio (NLR), platelet-to (PLR), lymphocyte-to monocyte (LMR), mean platelet volume (MPV)-to (MPVLR)], prognostic nutritional index (PNI) systemic immune-inflammation (SII) in predicting KD. Patients The medical records 134 KD patients admitted between...
Background/aim: Bacteremia remains an important cause of morbidity and mortality during febrile neutropenia (FN) episodes. We aimed to define the risk factors for bacteremia in neutropenic children with hemato-oncological malignancies. Materials methods: The records 150 patients aged ?18 years who developed FN hematology oncology clinics were retrospectively evaluated. Patients compared negative blood cultures.Results: mean age was 7.5 ± 4.8 years. Leukemia more prevalent than solid tumors...
Introduction: The beta thalassemias are common genetic disorders in Turkey and this retrospective study our aim was to evaluate β-globin chain mutations the phenotypic severity of β-thalassemia patients followed-up hospital, a tertiary center which serves from all regions Turkey. Materials Methods: 106 pediatric were analysed for gene by using DNA analysis. Patients classified as having major or intermedia based on age at diagnosis, transfusion frequency lowest hemoglobin concentration...
To investigate bone mineral density (BMD) in children with celiac disease (CD) and to evaluate the association between vitamin K levels osteoporosis.Children CD age- sex-matched healthy control subjects were prospectively included study. BMD was measured, serum anti-tissue transglutaminase IgA, ferritin, folate, B12, 25-hydroxy D K2, calcium, phosphate, alkaline phosphatase, parathormone assayed all subjects.Overall, 72 patients (mean age 11.69±3 years, 59.7% female) 30 12.27±2.12 63.3%...
Thrombotic thrombocytopenic purpura (TTP) is a rare, dangerous, life-threatening disease characterized by microangiopathic hemolytic anemia and thrombocytopenia, along with organ dysfunction due to microangiopathy-related ischemia. Plasma exchange steroids are used for initial treatment, rituximab often in refractive patients. Caplacizumab, cyclophosphamide, splenectomy among other treatment options. It has been reported that bortezomib, proteasome inhibitor, can be the management of...
Endocrine organs are highly susceptible to effects of high-dose chemotherapy. The objective the study was evaluate endocrine and metabolic complications after hematopoietic stem cell transplantation (HSCT) in children.The patients who underwent HSCT our center from April 2010 October 2014 with at least 1 year follow-up were analyzed retrospectively.One-hundred children (M/F:59/41; mean age 8.9±4.8 years, time 3.4±1.2 years) included study. Female hypogonadism most common dysfunction (35.7%),...
Güngör A, Yaralı N, Fettah Ok-Bozkaya İ, Özbek Kara A. Hereditary spherocytosis: Retrospective evaluation of 65 children. Turk J Pediatr 2018; 60: 264-269. spherocytosis (HS) is a common cause congenital hemolytic anemia in Caucasians and it could be diagnosed at any age. The aim this study to examine the demographic characteristics, clinical features laboratory findings children with HS their complications observed during follow up. Sixty-five patients, hereditary between January 2008...
Abstract Background Vitamin D receptor ( VDR ) polymorphisms have been studied in immune‐mediated disorders, but not yet immune thrombocytopenic purpura ITP ). We investigated whether variants were associated with children. Methods The study included 44 children a diagnosis of and 100 healthy controls. Five (Cdx‐2, FokI, BsmI, ApaI TaqI) genotyped used to evaluate the association . Results distribution three Cdx‐2 genotype groups GG , GA AA was significantly different between patients...
Hepatosplenic candidiasis (HSC) is a form of invasive fungal infection that occurs most commonly in patients with acute leukemia treated chemotherapy and requires protracted antifungal therapy. Immune reconstitution inflammatory syndrome (IRIS) best characterized as dysregulated responses triggered by rapid resolution immunosuppression.We present child diagnosed standard-risk precursor B cell-acute lymphoblastic who developed HSC Candida-related IRIS during recovery neutropenia associated...
Improvement in long-term survival patients with acute lymphoblastic leukemia (ALL) childhood has led to the need for monitorization of treatment-related morbidity and mortality. In current study, we aimed evaluate endocrine side effects treatment ALL survivors who were remission at least 2 years.Sixty diagnosed ALL, years, cross-sectionally evaluated complications.The median age time diagnosis, chemotherapy completion, study was 5 years (minimum-maximum: 1.7-13), 8 4.25-16), 11.7 7-22),...
The aim of this study was to investigate the effects donor characteristics on CD34+ cell yield in BM harvest. Between April 2010 and November 2013, consecutive donors who underwent harvesting our transplantation unit were retrospectively investigated. Donors classified into two groups: those donated without mobilization (steady-state donors) received G-CSF for stem (G-CSF-primed donors). Donor (age, gender, race, body weight, BMI, laboratory factors including donor's leukocyte, platelet,...
Hb Adana (HBA1: c.179G > A) is a very rare, unstable form of α-globin variant that results from deficient synthesis functional α chains. We present 2-month-old boy with hypochromic microcytic anemia, and remarkable anisocytosis, target cells basophilic stippling on his peripheral blood smear. α-Globin gene analysis the patient determined homozygosity for HBA1: A, mutation known as Adana. On follow-up visit, hemoglobin (Hb) levels were stable at 9.0–9.5 g/dL mean corpuscular volume (MCV) was...
Invasive fungal infections (IFIs) constitute a leading cause of morbidity and infection-related mortality among hematopoietic stem cell transplant (HSCT) recipients. With the use secondary prophylaxis, history IFI is not an absolute contraindication to allo-HSCT. However, still, recurrence remains risk factor for transplant-related mortality. In this study, 105 children undergoing HSCT between April 2010 February 2013, 10 patients who had before transplantation undergone allo-HSCT were...
Massive splenic infarction and portal vein thrombosis (PVT) due to chronic myeloid leukemia (CML) is extremely rare. We describe 2 children who were presented with massive PVT in the course of CML. treated splenectomy one medical treatment another whom resolved by cytoreductive treatment, led downsizing spleen or splenectomy. Splenic infarct should be considered CML patients long-lasting severe abdominal pain despite appropriate attempts. Splenectomy spared for persistent symptoms complications.
A 12-year-old male patient diagnosed with congenital afibrinogenemia presented to our center pain, swelling, and ecchymosis in his leg after trauma.His past medical history revealed that he had been shortly birth because of umbilical bleeding.Laboratory tests at admission prolonged prothrombin time activated partial thromboplastin time, almost undetectable fibrinogen levels.A bone scan radiograms both legs showed multiple cystic lesions the tibiae (Figure 1).Magnetic resonance imaging (MRI)...
Heavy menstrual bleeding (HMB) is a common condition in adolescents. However, disorders are known to be one of the causes HMB adolescent girls, so they should considered. Simple methods that can used primary health care needed determine whether patients have disorders. The aim this study was evaluate score admitted with and diagnostic value who were symptomatic but whose initial hemostatic tests normal.A total 113 adolescents 20 healthy girls included study. Pediatric Bleeding Questionnaire...
Abstract Background In patients with acute lymphoblastic leukemia (ALL), the risk of thromboembolism increases due to hemostatic changes secondary primary disease and treatment‐related factors. this multicenter study, we aimed research frequency central nervous system (CNS) thrombosis occurring during treatment, hereditary acquired factors, clinical laboratory features thrombosis, treatment approaches, thrombosis‐related mortality morbidity rates in pediatric ALL patients. Procedure...