Vascular malformations (VMs) are described as congenital of the vasculature derived from capillaries, veins, lymphatic vessels, arteries, or a combination these vessels. They can cause significant morbidity resulting soft tissue hypertrophy-related disfiguration, bony abnormalities, and even organ compromise. usually treated with various interventional procedures to achieve local control; however, chance success decreases anatomical distribution malformation widens. Unfortunately, medical...

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome of excessive immune activation. Secondary HLH develops as complication infection, drugs, rheumatologic conditions, or malignancy. The main objectives this work were to identify the etiology secondary and prognostic factors associated with mortality. Patients diagnosed HLH, between January 2011 December 2016, retrospectively included in study. We analyzed clinical laboratory findings well from 24 pediatric patients HLH....

Abstract Aim Pediatric testicular tumors are rare entities accounting for only 1–2% of all pediatric solid tumors. We aimed to present the experiences a tertiary hospital on and reveal changing surgical treatment trends over years. Methods The patients who underwent surgery scrotal between 1992 2022 were reviewed retrospectively. patients' demographic data, laboratory, radiologic, histopathological, findings, postoperative follow-up evaluated. evaluated as prepubertal, postpubertal, in...

In the management of pediatric thyroid nodules with atypia undetermined significance (AUS) cytology, The American Thyroid Association (ATA) guidelines recommend surgery while European (ETA) fine-needle aspiration biopsy (FNAB) repetition after 6 months. aim this study is to determine markers malignancy in AUS cases and discuss nodules. specimens 20 patients who underwent due cytology were re-evaluated subcategorized according Bethesda 2023 classification. On histological diagnosis cases, 11...

Infection by human herpesvirus 8 (HHV-8) in childhood is common the Mediterranean basin; however, classic Kaposi sarcoma (KS) exceedingly rare children not infected with HIV and receiving immunosuppression, only 30 cases having been reported since 1960. We recently 2 autosomal X-linked recessive primary immunodeficiencies underlying KS a context of multiple clinical manifestations. These reports suggested that otherwise healthy might also result from inborn errors immunity more specific to...

Objective: To evaluate the effectiveness and safety of sirolimus therapy in a child with macroglossia due to lymphatic malformation. Methods: Sirolimus treatment was applied patient an initial dosing 0.8 mg/m 2 per dose, administered orally, twice daily at approximately 12-hour intervals. Results: After 9 months therapy, there nearly complete resolution The last evaluation performed 6 after withdrawal treatment, lesion had almost completely resolved. Conclusion: This article presents novel...

Abstract 6‐Mercaptopurine (6MP) is an essential anticancer drug used in the treatment of childhood acute lymphoblastic leukemia (ALL). Thiopurine methyltransferase (TPMT) polymorphisms are major determinants interindividual differences severe toxicity or efficacy 6MP. Four variant alleles, TPMT*2 , TPMT*3A TPMT*3B and TPMT*3C responsible over 80% low undetectable enzyme activity. The frequencies these variants were investigated among 106 children with ALL Turkish population. only deficiency...

The molecular etiology of childhood acute lymphoblastic leukemia (ALL) is likely to involve interactions between environmental factors and genetic make up. Understanding these various predisposing genes for the risk developing considerable importance. CYP2E1 a susceptible gene in this respect, especially its capacity bioactivate many procarcinogens including benzene N-nitrosodimethylamine. possesses several polymorphisms humans, among them, CYP2E1*5B *6 have been shown be associated with...

Anthracycline chemotherapeutic agents carry the well-recognised risk of cardiac toxicity. The aim this study was to determine long-term effect anthracycline chemotherapy on biventricular function in childhood cancer survivors using tissue Doppler imaging and two-dimensional speckle tracking echocardiography.The included 45 cancers 50 healthy age-matched control patients. Cardiac prospectively studied with conventional echocardiography, imaging, echocardiography after completion treatment....

Testicular microlithiasis (TM), a rare condition characterized by calcification within the seminiferous tubules, is associated with benign and malignant disorders of testis. We review current practices following up pediatric patients diagnosed TM incidentally on scrotal ultrasonography (US). analyzed retrospectively patient characteristics, family history, indications for US, pathological features, US findings, outcome, follow-up. At our institution, 2875 examinations were performed 2477...

Abstract Background Vitamin D receptor ( VDR ) polymorphisms have been studied in immune‐mediated disorders, but not yet immune thrombocytopenic purpura ITP ). We investigated whether variants were associated with children. Methods The study included 44 children a diagnosis of and 100 healthy controls. Five (Cdx‐2, FokI, BsmI, ApaI TaqI) genotyped used to evaluate the association . Results distribution three Cdx‐2 genotype groups GG , GA AA was significantly different between patients...

Through its receptor (VDR), vitamin D

Background . Trichosporon asahii is an opportunistic fungus that causes infections in immunosuppressed patients. Neutropenia developing due to malignancies important risk factor for fungal infection. Case Report. We present two pediatric oncology cases successfully treated with voriconazole after T. infection known cause fatal sepsis and invasive Conclusion. There no conclusive evidence the antifungal agent effective neutropenic patients infected Liposomal amphotericin B has also been...

Ca 125 is a tumor marker for the diagnosis and monitoring of ovarian carcinoma. We investigated serum levels in 44 children with leukemia 59 lymphoma at initial presentation 4 weeks after chemotherapy. Serum were measured chemilumimetrically sandwich enzyme-linked immunosorbent assay. The incidence elevated was significantly higher (14 children) (26 than healthy (2 children). In patients non-Hodgkin's (NHL) who had abdominal involvement and/or serous membrane (ascides, pleural, pericardial...

Objective: To compare standardized uptake values (SUV) derived from pre-treatment 18 F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) imaging and clinical prognostic factors in pediatric patients with Hodgkin lymphoma (HL).Methods: Pre-treatment FDG PET/CT findings of 28 children HL were evaluated this retrospective study.Metabolic tumor volume (MTV), SUV max normalized by weight (SUV ), lean body mass lbm surface area bsa ) plasma glucose levels tumors...

Germ cell tumor (GCT) is a rare malignancy accounting for 2-3% of all pediatric tumors. The overall survival rate children and adolescents with GCT more than 80% after adopting combined therapy. aim this study to review clinical presentation, management, outcome in single-center series extracranial GCT. Clinical characteristics, pathologic presentations, outcomes 101 GCT, treated at our hospital from 1988 2011, were analyzed. Sixty-two patients female 39 them male. Fifty-eight (57%) had...

Ewing`s sarcoma (ES) is the second most common childhood primary malignant tumor of bone. The popular locations ES are long bones and pelvis. involvement mandible very rare in childhood. In last 10 years, we met with three cases our department. Initially patients had symptoms similar to periodontal inflammation. might be considered inflammation its initial stages, what frequently leads delayed treatment. Although this has an aggressive clinical behavior rapid growth, early diagnosis can...

Vitamin D receptor (VDR) polymorphisms are found more commonly in some tumor types than healthy individuals, suggesting that (Cdx2, Fok1, Bsm1, Apa1, Taq1) contribute to development. There is no previous report on VDR polymorphism Hodgkin’s lymphoma (HL) patients. patterns 95 pediatric HL cases with 100 controls were compared. No statistically significant difference was between the patient group and control terms of Cdx2, Taq1 ( P >0.5). Our findings suggest may not play a role

Kikuchi–Fujimoto disease (KFD) is a histiocytic necrotising lymphadenitis characterised by painful cervical lymphadenopathy, fever, malaise and weight loss. Infections, auto-immune pathogenesis genetic association have been implicated. A 12-year-old boy presented with 1-month history of abdominal pain, constipation loss, lymph node was detected in the right axilla. Chest CT demonstrated multiple nodes, especially left mediastinum. Salmonella enteritidis group D blood culture he treated...