Melike Emiroğlu
A5086304897- Bacterial Infections and Vaccines
- Pneumonia and Respiratory Infections
- Kawasaki Disease and Coronary Complications
- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- Streptococcal Infections and Treatments
- COVID-19 Clinical Research Studies
- Hepatitis Viruses Studies and Epidemiology
- Diabetes and associated disorders
- Immunodeficiency and Autoimmune Disorders
- Viral gastroenteritis research and epidemiology
- Infective Endocarditis Diagnosis and Management
- Blood disorders and treatments
- Tuberculosis Research and Epidemiology
- Immune Cell Function and Interaction
- Hepatitis B Virus Studies
- Coronary Artery Anomalies
- Infection Control and Ventilation
- Herpesvirus Infections and Treatments
- Neonatal Respiratory Health Research
- Neutropenia and Cancer Infections
- COVID-19 and Mental Health
- Mechanical Circulatory Support Devices
- Helicobacter pylori-related gastroenterology studies
- Diagnosis and treatment of tuberculosis
Selçuk University
2016-2025
Selçuk Üniversitesi Tıp Fakültesi Hastanesi
2017-2024
Office of Infectious Diseases
2023
Government of Western Australia Department of Health
2023
Pediatrics and Genetics
2023
National Institute of Allergy and Infectious Diseases
2022
National Institutes of Health
2022
Institute of Cardiology
2019
Necmettin Erbakan University
2014-2016
Konya Eğitim ve Araştırma Hastanesi
2011-2016
Recessive or dominant inborn errors of type I interferon (IFN) immunity can underlie critical COVID-19 pneumonia in unvaccinated adults. The risk children, which is much lower than adults, remains unexplained. In an international cohort 112 children (<16 yr old) hospitalized for pneumonia, we report 12 (10.7%) aged 1.5–13 with (7 children), severe (3), and moderate (2) 4 the 15 known clinically recessive biochemically complete IFN immunity: X-linked TLR7 deficiency children) autosomal...
Patients with autoimmune polyendocrinopathy syndrome type 1 (APS-1) caused by autosomal recessive AIRE deficiency produce autoantibodies that neutralize I interferons (IFNs)1,2, conferring a predisposition to life-threatening COVID-19 pneumonia3. Here we report patients NIK or RELB deficiency, specific of autosomal-dominant NF-κB2 also have neutralizing against IFNs and are at higher risk getting pneumonia. In these found only in individuals who heterozygous for variants associated both...
We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients: IFN-α2 only three, plus IFN-ω five, and IFN-α2, IFN-β two; nine patients). Seven (3.8%) Abs at least ng/ml one IFN, whereas the other 12 (6.6%) 100 pg/ml. The auto-Abs neutralized both unglycosylated glycosylated IFNs. also detected pg/ml 4 2,267 uninfected (0.2%) 45 (2%). odds ratios (ORs) life-threatening were, therefore,...
Principal component analysis (PCA), homozygosity rate estimations, and linkage studies in humans are classically conducted through genome-wide single-nucleotide variant arrays (GWSA). We compared whole-exome sequencing (WES) GWSA for this purpose. analyzed 110 subjects originating from different regions of the world, including North Africa Middle East, which poorly covered by public databases have high consanguinity rates. tested applied a number quality control (QC) filters. Compared with...
Objectives: The aim of this study is to identify the epidemiological, clinical, and laboratory features coronavirus disease 2019 (COVID-19) in children. Methods: A retrospective was conducted by pediatric infectious specialists from 32 different hospitals all over Turkey case record forms. Pediatric cases who were diagnosed as COVID-19 between March 16, 2020, June 15, 2020 included. Case characteristics including age, sex, dates onset diagnosis, family, contact information recorded. Clinical...
Most cases of herpes simplex virus 1 (HSV-1) encephalitis (HSE) remain unexplained
Immunoprophylaxis is routinely recommended for infants born to mothers with hepatitis B virus (HBV) infection within the first 12-24 hours. Detection of surface antibody (HBsAb) resulting from immunoglobulin administered at birth may be perceived as a real vaccine response. This makes it difficult detect HBV infection. For this reason, that antigen positive and who received immunoprophylaxis should have HBsAb testing when they are 9-15 months old.
The etiology of bacterial meningitis in Turkey changed after the implementation conjugated vaccines against Streptococcus pneumoniae and Haemophilus influenzae type b (Hib) Turkish National Immunization Program (NIP). Administration Hib vaccine PCV-7 (7-valent pneumococcal conjugate vaccine) was implemented NIP 2006 2009, respectively. In 2011, replaced with PCV-13. Meningococcal have not yet been included NIP. This prospective study comprised 27 hospitals located seven regions represented...
This is an observational epidemiological study to describe causes of bacterial meningitis among persons between 1 month and 18 y age who are hospitalized with suspected in 7 Turkish regions. covering 32% the entire population Turkey. We present here results from 2013 2014. A clinical case was defined according followings: any sign including fever, vomiting, headache, meningeal irritation children above one year fever without documented source, impaired consciousness, prostration seizures...
Inborn errors of IFN-γ immunity can underlie tuberculosis (TB). We report three patients from two kindreds without EBV viremia or disease but with severe TB and inherited complete ITK deficiency, a condition associated that renders immunological studies challenging. They have CD4+ αβ T lymphocytopenia concomitant expansion CD4−CD8− double-negative (DN) Vδ2− γδ lymphocytes, both displaying unique CD38+CD45RA+T-bet+EOMES− phenotype. Itk-deficient mice recapitulated an the DN lymphocyte...
Objectives: Septic arthritis (SA) is a serious bacterial infection that must be treated efficiently and timely. The large number of culture-negative cases makes local epidemiological data important. Accordingly, this study aimed to evaluate the etiology, clinical characteristics, therapeutic approach SA in children Turkiye, emphasizing role real-time polymerase chain reaction (PCR) techniques diagnosis. Methods: In multi-center, prospective study, hospitalized due between February 2018 July...
To contribute to the diagnosis and treatment of pediatric abdominal tuberculosis cases by assessing clinical, laboratory, radiological features patients who presented at our clinic were diagnosed with tuberculosis.Clinical, reviewed retrospectively for 35 followed up Pediatric Infectious Diseases Clinic between January 1987 August 2012.The study group included 16 female (45.7%) 19 male (54.3%) an age range 6 months years (mean: 9.77±4.36 years). Twenty-nine peritonitis, five intestinal...
Successful vaccination policies for protection from invasive pneumococcal diseases (IPD) dependent on determination of the exact serotype distribution in each country. We aimed to identify serotypes strains causing IPD children Turkey and emphasize change before after with 7-valent conjugate vaccine (PCV-7) was included PCV-13 newly changed Turkish National Immunization Program. Streptococcus pneumoniae were isolated at 22 different hospitals Turkey, which provide healthcare services...
Shunt infections are seen in 3% to 20% of patients who have cerebrospinal fluid (CSF) shunts. Although the staphylococcal species most common cause shunt-related infections, Gram-negative bacteria increasingly reported with higher mortality rates. Tigecycline, a glycylcycline, is not approved for children. But era nosocomial due multidrug-resistant pathogens, it can be life-saving option. We report an infant ventriculoperitoneal meningitis treated tigecycline combination regimen. A...
Objectives: To determine the serotype distribution of pneumococcus causing invasive pneumococcal disease (meningitidis, bacteremia and empyema) in children Turkey, to observe potential changes this time guide effective vaccine strategies.Methods: We surveyed S. pneumoniae with conventional bacteriological techniques real-time polymerase chain reaction (RT-PCR) samples cerebrospinal fluid (CSF), blood pleural fluid. strains were isolated from 33 different hospitals which are giving health...