A5029876637- COVID-19 Clinical Research Studies
- Inflammasome and immune disorders
- Pancreatitis Pathology and Treatment
- GDF15 and Related Biomarkers
- Liver Disease Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Neutropenia and Cancer Infections
- SARS-CoV-2 and COVID-19 Research
- Blood disorders and treatments
- Adipose Tissue and Metabolism
- Vitamin C and Antioxidants Research
- Retinal and Optic Conditions
- Folate and B Vitamins Research
- Nigella sativa pharmacological applications
- Cerebrovascular and Carotid Artery Diseases
- Lipoproteins and Cardiovascular Health
- Diet and metabolism studies
- Streptococcal Infections and Treatments
- Cardiovascular Function and Risk Factors
- Sleep and Work-Related Fatigue
- Inflammation biomarkers and pathways
- Inflammatory Biomarkers in Disease Prognosis
- Bioactive Compounds and Antitumor Agents
- Congenital Heart Disease Studies
- Nutrition, Health and Food Behavior
Selçuk University
2015-2024
Selçuk Üniversitesi Tıp Fakültesi Hastanesi
2020-2024
Usak University
2023
KTO Karatay University
2022
Istanbul Arel University
2022
Atlas Üniversitesi
2022
Sağlık Bilimleri Üniversitesi
2020
Izmir University
2020
Istanbul University
2020
Cukurova University
2020
: Inflammatory bowel diseases primarily encompass Crohn's disease and ulcerative colitis. Insufficient levels of tryptophan cause an imbalance in the gut microbiota, leading to inflammation gastrointestinal tract. The main catabolic pathway is kynurenine pathway. Our study aims evaluate serum tryptophan, pathway, oxidative stress parameters, including total oxidant status antioxidant capacity, patients with
BACKGROUND/AIMS: Chronic obstructive pulmonary disease (COPD) is a common chronic airway with acute exacerbations of varying frequency that the main cause morbidity and mortality. The aim this study was to investigate utility extracts flavanol-3-ols rich (%85-92) Juniperus drupacea fruit in treatment rats PPE-induced COPD.
Abstract Objective Our aim in this study was to evaluate the levels of Activating Transcription Factor‐6 (ATF‐6), Inositol‐Requiring Enzyme 1 (IRE‐1), and C/EBP‐Homologous Protein (CHOP), which are critical markers endoplasmic reticulum (ER) stress, patients with gestational diabetes mellitus (GDM), a condition increasingly recognized for its complex biochemical molecular underpinnings. Materials Methods A total 89 aged 18–45 years who applied our hospital between January 2024 December were...
Abstract A nationwide multicenter study was organized to establish reference intervals (RIs) in the Turkish population for 25 commonly tested biochemical analytes and explore sources of variation values, including regionality. Blood samples were collected 28 laboratories from seven regions (≥400 samples/region, 3066 all). The sera collectively analyzed Uludag University Bursa using Abbott reagents analyzer. Reference materials used standardization test results. After secondary exclusion...
This study aims to evaluate the effect of quercetin on fracture healing in an open model rats.A total 80 Wistar-Albino male rats were used this study. The divided into 10 groups. Daily oral treatment 100 mg/kg dissolved corn oil given four groups, whereas other group control treated with only. Histopathological and radiological examinations performed at end Weeks 2 4 these rats, while biomechanical biochemical 6, since harder callus was required. Among last two that not subjected model, one...
To measure products of free radical damage in childhood obesity.Plasma radicals were assayed 24 children with exogenous obesity and non-obese healthy controls. A new colorimetric method was used that measures the generation peroxy (D-Roms), first reaction between oxygen.D-Roms levels higher obese than group (33.3+/-10.1 mg% H2O2 vs 22.8+/-2.8 H2O2; p <0.001). Moreover, D-Roms hyperlipidemia normolipidemia (49.6+/-3.1 27.8+/-3.2 level positively correlated waist-hip ratio, serum total...
Many plants such as Dracaena cinnabari have been used in traditional medicine since ancient times due to their including bioactive compounds phenolic compounds, tocopherols, and organic acids. The aim of present study is determine the presence diversity components phenolic, acids tocopherols resin extracts, reveal which solvents can be effective extraction these what extent. Methanol, ethanol, chloroform, water, vinegar were resin. widest was obtained with for acids, methanol solvent...
Abstract Introduction A nationwide multicentre study was conducted to establish well-defined reference intervals (RIs) of haematological parameters for the Turkish population in consideration sources variation values (RVs). Materials and methods K2-EDTA whole blood samples (total 3363) were collected from 12 laboratories. Sera also measurements iron, UIBC, TIBC, ferritin use latent abnormal exclusion (LAVE) method. The analysed within 2 hours each laboratory using Cell Dyn Ruby (Abbott),...
To examine the effects of calcium antagonists nimodipine and magnesium sulfate (MgSO4) on tissue endogenous antioxidant levels, authors studied superoxide dismutase (SOD) glutathione peroxidase (GPx) levels in rabbit brain 1 hour after experimental head trauma. Forty New Zealand rabbits were anesthetized randomly divided into four groups. Group (n = 10) was sham operated group. 2 10), control group, received trauma no treatment. 3 intravenous (IV) μgr/kg nimodipine. 4 IV 100 mg/kg MgSO4....
The aim of this study was to examine whether asymmetric dimethylarginine (ADMA) concentrations are associated with ventricular function in the infants mothers gestational diabetes.Twenty-five term newborns diabetes and as control group (n = 25) normal general health status were evaluated at two time points, on 3rd postnatal day, 3th months. Echocardiographic evaluations all participants performed ADMA level measured.In first analysis, 10 patients (40%) had a septal thickness 6 mm or more,...
The COVID-19 pandemic has brought countries' health services into sharp focus. It was drawn to our group's attention that healthcare workers (HCWs) had a lower mortality rate against higher incidence compared the general population in Turkey. Since risk of exposure tuberculosis bacillus among are than population, we aimed investigate if there is relationship between BCG and Mycobacterium history with severity infected HCWs. This study conducted 465 HCWs from thirty-three hospitals assess...
AIM: Noscapine, a naturally occurring alkaloid obtained from opium poppy, is microtubule-targeting agent.This study aimed to investigate the effects of noscapine on human breast cancer cell lines by comparing them with those tamoxifen and docetaxel.METHODS: MCF-7 MDA MB-23 were used observe docetaxel, tamoxifen, proliferation.For each drug, blocks prepared cultured cells treated IC50 dose drug these examined histologically.The expressions Ki-67, Bcl-2, BAX, cyclin-D1 assessed...
Abstract The novel coronavirus disease 2019 (COVID‐19) remains a global health emergency, and understanding the interactions between virus host immune responses is crucial to preventing its lethal effects. expansion of myeloid‐derived suppressor cells (MDSCs) in COVID‐19, thereby suppressing responses, has been described as responsible for severity disease, but correlation MDSC subsets COVID‐19 elusive. Therefore, we classified patients according clinical laboratory findings—aiming...
In this study, chemical composition such as vitamins, fatty acids and trace elements of Nigella sativa L. seeds collected from East Anatolia Region Turkey were investigated. Fatty in the lipid extracts converted into methyl esters. The esters extracted with n-hexane, they w ere se parated quantified by g c hromatography. F at solub le vitamins deter mined HPLC mixture acetonitrile/methanol (3/1, v/v) was used mobile phase. or determination levels, solutions microwave digestion a certain...
Ischemia-reperfusion models are used to evaluate treatment options that may minimize cellular damage after ischemia.To investigate the effects of amantadine and topiramate on apoptosis oxidative damage.This experiment was performed using 30 male Wistar albino rats. The right internal carotid artery identified clamped with an aneurysm clip under general anesthesia, except for animals in control group. After 10 min occlusion, removed, allowing reperfusion. reperfusion a waiting period 12 h,...
Background: The progression of COVID-19 has different clinical presentations, which raises a number immunological questions.
 Objectives: This study aimed to investigate MMP-9 and TIMP-1 levels in patients diagnosed with whether the MMP-9/TIMP-1 ratio is associated lung involvement COVID-19.
 Methods: was conducted 192 45 healthy controls. ELISA used measure TIMP-1.
 Results: were found be higher than those TIMP- 1 detected more on chest CT scans no scans. A comparison...
Objective: Childhood obesity which is a predictor of adulthood associated with type 2 diabetes, metabolic syndrome, dyslipidemia, coronary artery diseases and subclinical inflammation. Growth differentiation factor-15, also known as macrophage inhibitory cytokine-1 (MIC-1/GDF15) member the transforming growth factor- β super family increases during inflammatory states. Adults have increased serum concentrations MIC-1/GDF15. MIC-1/GDF15 cardio risk in adults. Design: Identification obese...