A5031012297- Bipolar Disorder and Treatment
- Folate and B Vitamins Research
- Anesthesia and Neurotoxicity Research
- DNA Repair Mechanisms
- Autism Spectrum Disorder Research
- Alzheimer's disease research and treatments
- Genetics and Neurodevelopmental Disorders
- Clinical Laboratory Practices and Quality Control
- Law, logistics, and international trade
- Circadian rhythm and melatonin
- Metabolism, Diabetes, and Cancer
- Reliability and Agreement in Measurement
- Poisoning and overdose treatments
- Neonatal Health and Biochemistry
- Infant Nutrition and Health
- Acute Lymphoblastic Leukemia research
- Tryptophan and brain disorders
- Cardiac Arrest and Resuscitation
- Cultural and Sociopolitical Studies
- Drug Transport and Resistance Mechanisms
- Adolescent and Pediatric Healthcare
- Dietary Effects on Health
- Legal Issues in Turkey
- Cardiac Ischemia and Reperfusion
- Methemoglobinemia and Tumor Lysis Syndrome
Dokuz Eylül University
2016-2025
İzmir University of Economics
2023
Maltepe University
2023
Neurosciences Institute
2016
Abstract Background: Brain-derived neurotrophic factor (BDNF) and glial cell line-derived (GDNF) have essential roles in synaptic plasticity which is involved pathogenesis treatment of psychiatric disorders. However, it not clear whether they act simultaneously during illness states major Methods: BDNF GDNF serum levels were measured concomitantly by enzyme-linked immunosorbent assay (ELISA) method 171 patients diagnosed with schizophrenia ( n = 33), bipolar disorder-manic episode 39),...
Objectives: In the field of laboratory medicine, minimizing errors and establishing standardization is only possible by predefined processes. The aim this study was to build an experimental decision algorithm model open improvement that would efficiently rapidly evaluate results biochemical tests with critical values evaluating multiple factors concurrently. Methods: built Weka software (Weka, Waikato, New Zealand) based on artificial neural network method. Data were received from Dokuz...
Abstract A nationwide multicenter study was organized to establish reference intervals (RIs) in the Turkish population for 25 commonly tested biochemical analytes and explore sources of variation values, including regionality. Blood samples were collected 28 laboratories from seven regions (≥400 samples/region, 3066 all). The sera collectively analyzed Uludag University Bursa using Abbott reagents analyzer. Reference materials used standardization test results. After secondary exclusion...
Abstract Objectives Calcium/Calmodulin-dependent protein kinase-2 (CaMKII) is a serine/threonine kinase prevalent in neuronal cells, playing key role memory, learning, and synaptic plasticity. Nonspecific CaMKII inhibition can prevent apoptosis cells reduce glutamate-induced cell death. Additionally, variations CaMKK enzyme levels affect hemopoietic stem proliferation, although the effects of on responses during stress remain unclear. This study aims to explore CaMKII’s impact survival...
Background Bacterial peritonitis episodes may disturb the functional and histological integrity of peritoneum in peritoneal dialysis patients. The renin–angiotensin–aldosterone system have fibrotic effects on peritoneum. Objective To study an angiotensin II receptor antagonist (irbesartan) aldosterone (spironolactone) prevention fibrosis a rat model bacterial peritonitis. Methods 40 Wistar rats were randomized into 5 groups: bacteria (B), bacteria–irbesartan (BI), bacteria–spironolactone...
<i>Background and Aims:</i> Elevated plasma homocysteine (PH) levels have been identified as a risk factor for cardiovascular diseases. The aims of this study were to investigate the influences submaximal acute aerobic exercise training on PH lipid profiles. <i>Methods:</i> 69 volunteersubjects (21.12 ± 2.08 years) randomized three groups acute, control groups. Examination blood samples collected before immediately after in group 6 weeks later...
Abstract The use of C‐reactive protein (CRP) assays is increasing for a wide range clinical conditions, and consequently the analytical performance requirements CRP are also changing. For this reason, manufacturers have been developing based on different methodologies to provide both high sensitivity measuring range. However, it questionable whether these methods can meet desired assays. Latex Cobas Integra 400 Tina‐quant Modular Analytics‐P were evaluated in terms detection limit,...
Abstract Objective : The examination of the urine remains to be one most commonly performed tests in laboratory practice. Currently, laboratories also need accredit their diagnostics by comparing measurement methods acceptable references. In this study we compared particle counts obtained new generation automated technique, image capture analysis (IQ‐200) with those a standardized chamber counts. Design and Methods same 258 samples from different departments hospital assayed IQ‐200 were...
Objective: Many of the vaccines developed for COVID-19 have been approved clinical emergency use before their safety and preclinical studies completed. The main aim this study was to investigate effects an inactivated SARS-CoV-2 virus vaccine (Vero cells) on renal function in Balb/C Albino mice. Methods: 21 healthy, 6– 8 week old BALB/c male mice were divided into three equal groups, 0.10 mL intramuscular saline dose volume administered first group. To second group, a single 120 U Vero cell...
Objective. N-acetylcysteine (NAC) has yielded some promising results recently in the prevention of radiocontrast nephropathy (RCN). In this study, structural and functional effects NAC on RCN were analyzed. Material methods. Twenty-eight Wistar rats randomized into four groups, as follows: Group 1, controls; 2, contrast; 3, contrast + NAC; 4, NAC. All deprived water for 24 h then medium (ioxoglate; 10 ml/kg) was administered to Groups 2 3. (50 mg/kg) introduced enterally 3 4 at a dose 50...
Diabetes is a chronic illness and have relatively high prevalence. Glycemic control fundamental to the management of diabetes. Hemoglobin A1c (HbA1c) commonly used laboratory test monitor glycemia manage This study aimed assess appropriateness frequency HbA1c order with respect approved guidelines for monitoring glycaemia patients.To rate inappropriate orders, records tests ordered between 2002 2004 were evaluated. Inappropriate orders defined as any given patient that takes place within 29-...
Aim: The aim of the study was to evaluate macular pigment optical density (MPOD) levels in patients with wet age-related degeneration (AMD), dry AMD, and also healthy controls. Settings Design: This conducted at Department Ophthalmology, design a prospective study. Patients Methods: Forty-eight 51 50 controls were included All naive both previous lutein or zeaxanthin administration any intravitreal injections. Fundus reflectance (VISUCAM 500, single 460 nm wavelength) used measure MPOD...
Neurotrophic factors are known to be involved in the pathogenesis of mood disorders. However, precise neurobiology underlying relapse into depression or switch mania under antidepressant treatment is not fully understood. Evidence suggests role neuroplasticity these processes.Brain-derived neurotrophic factor and glial cell line-derived (GDNF) serum levels were measured concomitantly during electroconvulsive (ECT) 30 depressive patients (25 with unipolar, 5 bipolar depression), including...
The nocturnal peak of melatonin can be altered after anesthesia and surgery. We aimed to examine the levels during day night with three commonly used inhalational anesthetics. Forty-eight male Wistar albino rats were randomized into eight groups. Rats administered between 7:00 am 1:00 pm (day groups) or (night for 6 hours. At end anesthesia, blood samples collected assessing levels. Mean values hours daytime 43.17±12.95 control, 59.79±27.83 isoflurane, 50.75±34.28 sevoflurane 212.20±49.56...
Previous evidence suggests elevated levels of oxidatively-induced DNA damage, particularly 8-hydroxy-2'-deoxyguanosine (8-OH-dG), and abnormalities in the repair 8-OH-dG by base excision (BER) bipolar disorder (BD). However, genetic disposition these remains unknown. In this study, we aimed to investigate damage BER mechanisms individuals with BD their siblings, as compared healthy controls (HCs). 46 BD, 41 siblings 51 HCs were included study. Liquid chromatography-tandem mass spectrometry...
Abstract Objectives Determining low-density lipoprotein (LDL) is a costly and time-consuming operation, but triglyceride value above 400 (TG>400) always requires LDL measurement. Obtaining fast forecast by accurate prediction can be valuable to experts. However, if high error margin exists, critical unusable. Our objective level with an less than low total acceptable rate (% TEa). Methods present work used 6392 lab records predict the patient using state-of-the-art Artificial Intelligence...