A5016880215- Lipoproteins and Cardiovascular Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Disease and Adiposity
- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Atherosclerosis and Cardiovascular Diseases
- Atrial Fibrillation Management and Outcomes
- Cardiac Valve Diseases and Treatments
- Hormonal Regulation and Hypertension
- Diabetes Treatment and Management
- Acute Myocardial Infarction Research
- Cardiac, Anesthesia and Surgical Outcomes
- Paraoxonase enzyme and polymorphisms
- Venous Thromboembolism Diagnosis and Management
- Biomarkers in Disease Mechanisms
- Bone Tissue Engineering Materials
- Birth, Development, and Health
- Cardiac Ischemia and Reperfusion
- Vitamin D Research Studies
- Macrophage Migration Inhibitory Factor
- Pregnancy and preeclampsia studies
- Cardiovascular Health and Disease Prevention
Istanbul University-Cerrahpaşa
2020-2025
Istanbul University
2013-2023
Haseki Eğitim ve Araştırma Hastanesi
2021
Adli Tıp Kurumu
2020
Laboratoire de Biochimie
2011-2014
Research Institute of Complex Problems of Cardiovascular Disease Russian Academy of Medical Sciences
2014
European Union of Medical Specialists
2014
Yeditepe University
2014
Armed Forces Institute of Pathology
2014
University of Prishtina
2014
Abstract A nationwide multicenter study was organized to establish reference intervals (RIs) in the Turkish population for 25 commonly tested biochemical analytes and explore sources of variation values, including regionality. Blood samples were collected 28 laboratories from seven regions (≥400 samples/region, 3066 all). The sera collectively analyzed Uludag University Bursa using Abbott reagents analyzer. Reference materials used standardization test results. After secondary exclusion...
Procalcitonin (PCT) is implicated as an inflammatory marker in early atherosclerosis. In order to investigate the clinical consequences of increased PCT levels acute coronary syndrome (ACS), 77 patients (29 with non-ST-elevation myocardial infarction [MI], 34 ST-elevation MI and 14 unstable angina pectoris) were included followed up for 6 months. The determined at initial presentation within 48 h admission. Five died during hospitalization their admission significantly higher than survivors...
Extracorporeal perfusion systems utilized in open-heart surgeries with cardiopulmonary bypass can affect multiple body systems. The primary adverse effects of Perfusion Systems (EPS) on the hematological system include postoperative bleeding and coagulation issues. aim this study is to evaluate on-pump time cross-clamp duration total platelet count (PLT) indices performed using bypass. This evaluation achieved by comparing PLT, mean volume (MPV), distribution width (PDW), plateletcrit (PCT)...
This study is designed to evaluate the N-terminal pro-BNP (NTproBNP) levels in patients with mitral stenosis (MS) and its possible correlation clinical echocardiographic parameters of disease. The group consisted 29 isolated MS (patients greater mild regurgitation were excluded) 20 normal control subjects similar age gender distribution. Blood samples for NTproBNP collected at time examination. elevated compared controls (325 +/- 249 pg/dL [19.9-890] versus 43 36 [5.76-193.3], P < 0.001)....
Summary The aim of the study was to observe changes in haematological parameters and blood lipid profile through copper (Cu) deficiency. Eighty broiler chicks were used study. separated into two equal groups ( n = 40), feed treatment according started on day 7. animals control group fed with normal feed. Those Cu‐deficient that did not contain supplemental Cu. Blood samples taken from all days 7, 21 49. Fibrinogen prothrombin time assayed plasma; total cholesterol, high density lipoprotein...
Resistin, which is derived from the gene of RSTN, belongs to a family cysteine-rich secretory proteins called resistin-like molecules (RELMs). Increased serum resistin levels are associated with coronary artery disease (CAD) and risk cardiovascular death. Patients (n = 214) an initial diagnosis stable angina pectoris, unstable myocardial infarction without ST-segment elevation referred catheter laboratory for angiography were enrolled in study. We aimed investigate relationship between...
Background. In view of recent evidence that serum creatinine and dysfunctional apolipoprotein (apo)A-I may serve as inflammation mediators in people with enhanced inflammation, we studied whether or not these molecules were interrelated associated coronary heart disease (CHD) likelihood even subjects without metabolic syndrome (MetS) type-2 diabetes. Methods. Among unselected middle-aged Turkish adults available apo A-I, lipoprotein(a) measurements, 697 participants (designated 'healthy')...
Background and aim High-dose statin therapy before percutaneous coronary intervention (PCI) is thought to reduce the occurrence of Peri-procedural Myocardial Infarction (PPMI), which associated with increased mortality prolonged hospitalization, especially in naïve patients. This study aims investigate effect rosuvastatin loading dose on PPMI major adverse cardiac cerebrovascular events (MACCE) patients undergoing elective PCI, considering their use. Methods One hundred sixty-five stable...
We aimed to investigate the role of oxidative stress related with ischemia- reperfusion damage on pathogenesis atrial fibrillation (AF) developing after coronary artery bypass graft (CABG) surgery.In our prospective, single-center study, 118 patients who underwent elective isolated on-pump CABG surgery were included. Patients divided into two groups according development postoperative (POAF) as Group 1: developed POAF, and 2: remained in sinus rhythm. In addition preoperative demographic,...
Objectives: Some evidence suggests that serum lipoprotein[Lp](a) may be inversely linked to type-2 diabetes. We aimed determine in nondiabetic people the relationship of [Lp](a) with insulin resistance and new-onset diabetes (NOD).Materials methods: Population-based middle-aged adults (n = 1685) were categorized by fasting glucose stratified gender, having excluded prevalent diabetic subjects. NOD 90) occurred over a median 5 years' follow-up.Results: Subjects subsequently developed NOD,...
Introduction. Extracorporeal circulation (ECC) related systemic oxidative stress is a well-known entity but the underlying mechanisms are not clearly described. Our aim was to investigate relation between indices, inflammatory markers, and phosphorylcholine-coated (PCC) ECC systems. Patients Methods. Thirty-two consecutive coronary artery bypass grafting (CABG) cases were randomly assigned Group I (PCC, n = 18) II (noncoated, 14) circuits. Total Antioxidant Status (TAS), Oxidant (TOS), Tumor...
Metabolic syndrome is associated with cardiovascular disease and oxidative stress. The aim of this study was to investigate the differences novel stress parameters lipid profiles in men women metabolic syndrome.The population included 88 patients syndrome, consisting 48 postmenauposal (group I) 40 II). Premenauposal were excluded. Plasma levels total antioxidant status (TAS) (TOS) determined by using Erel automated measurement method, index (OSI) calculated. To perform calculation, resulting...
We determined the effect of 6-month rosuvastatin treatment on blood lipids, oxidative parameters, apolipoproteins, high-sensitivity C-reactive protein, lipoprotein(a), homocysteine, and glycated hemoglobin (HbA1c) in patients with metabolic syndrome (MetS). Healthy individuals (men aged >40 years postmenopausal women) a body mass index ≥ 30 (n = 100) who fulfilled National Cholesterol Education Program Adult Treatment Panel III diagnostic criteria for MetS were included. Total cholesterol...
AIM:To assess the association of a surrogate fatty liver disease (FLD) with incident type-2 diabetes, coronary heart disease, and all-cause mortality. METHODS:In prospective population-based study on 1822 middle-aged adults, stratified to gender, we used an algorithm index (FLI) identify associations outcomes.An ≥ 60 indicated presence FLD.In Cox regression models, adjusted for age, smoking status, high-density lipoprotein cholesterol, systolic blood pressure, assessed predictive value FLI...
Background Atrial fibrillation (AF) is a very common cardiac arrhythmia, and associated with an increased mortality in patients hypertension. Whether the best therapeutic approach for these to restore sinus rhythm (SR) or adequately control ventricular rate still controversial. The aim of this study compare both strategies Methods Results Two hundred twenty-one hypertension AF duration >48 h were randomly assigned either (n=155) (n=66) group. Exercise capacity was improved group 1st year...
To investigate whether impaired fasting glucose (IFG) confers cardiovascular risk.A non-diabetic population-based sample representative of middle-aged and elderly Turks was studied at 8.5 years' follow-up for incident diabetes coronary heart disease (CHD). Metabolic syndrome (MetS) defined by ATP-III criteria modified male abdominal obesity, IFG type 2 were identified the American Diabetes Association. Stratification presence MetS used. Outcomes predicted providing estimates hazard ratio...