Hidayet Ece Arat-Çelik

ORCID: 0000-0002-0880-8974
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About
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Research Areas
  • Bipolar Disorder and Treatment
  • Tryptophan and brain disorders
  • Genetics and Neurodevelopmental Disorders
  • Adolescent and Pediatric Healthcare
  • Electrolyte and hormonal disorders
  • DNA Repair Mechanisms
  • Epigenetics and DNA Methylation
  • Adipokines, Inflammation, and Metabolic Diseases
  • Child Nutrition and Feeding Issues
  • Pharmacological Effects and Toxicity Studies
  • Mitochondrial Function and Pathology
  • RNA Research and Splicing
  • Cancer-related molecular mechanisms research
  • RNA modifications and cancer
  • Metabolism and Genetic Disorders
  • Maternal Mental Health During Pregnancy and Postpartum
  • Neuroinflammation and Neurodegeneration Mechanisms

Maltepe University
2023-2024

Dokuz Eylül University
2023

İzmir University of Economics
2023

Addictive disorders are associated with systemic and central nervous system inflammation, which may be important for the onset development of these diseases. Although lymphocyte-related parameters have recently been studied in alcohol use disorder (AUD), immune-inflammation index (SII) inflammatory response (SIRI) haven't. Lymphocyte-related ratios, SII SIRI levels were evaluated between AUD healthy controls (HC) this study. It was a retrospective cross-sectional This study included 72...

10.1080/15321819.2023.2277806 article EN Journal of Immunoassay and Immunochemistry 2023-11-12

Previous evidence suggests elevated levels of oxidatively-induced DNA damage, particularly 8-hydroxy-2'-deoxyguanosine (8-OH-dG), and abnormalities in the repair 8-OH-dG by base excision (BER) bipolar disorder (BD). However, genetic disposition these remains unknown. In this study, we aimed to investigate damage BER mechanisms individuals with BD their siblings, as compared healthy controls (HCs). 46 BD, 41 siblings 51 HCs were included study. Liquid chromatography-tandem mass spectrometry...

10.1038/s41398-024-02901-3 article EN cc-by Translational Psychiatry 2024-05-24

Previous studies have suggested a possible connection between childhood trauma, the course of illness, and neurocognitive impairment in individuals with bipolar disorder (BD). This cross-sectional study aimed to investigate relationship trauma functioning sample consisting 41 euthymic BD, 37 who at least one sibling 48 healthy controls (HCs). We assessed history using Childhood Trauma Questionnaire (CTQ). Both BD Sibling groups showed higher rates emotional abuse, neglect, total scores...

10.1016/j.nsa.2023.101138 article EN cc-by-nc-nd Neuroscience Applied 2023-01-01

Abstract Previous evidence suggests elevated levels of oxidative DNA damage, particularly 8-hydroxy-2'-deoxyguanosine (8-OH-dG), and abnormalities in the repair 8-OH-dG by base excision (BER) BD. However, genetic disposition these remains unknown. In this study, we aimed to investigate damage BER mechanisms individuals with BD their siblings, as compared healthy controls (HCs). 46 BD, 41 siblings 51 HCs were included study. Liquid chromatography-tandem mass spectrometry was employed evaluate...

10.21203/rs.3.rs-3273378/v1 preprint EN cc-by Research Square (Research Square) 2023-10-09
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