A5039246008- Immunodeficiency and Autoimmune Disorders
- Asthma and respiratory diseases
- Blood disorders and treatments
- Immune Cell Function and Interaction
- Allergic Rhinitis and Sensitization
- Blood groups and transfusion
- Respiratory viral infections research
- Drug-Induced Adverse Reactions
- Pediatric health and respiratory diseases
- Respiratory and Cough-Related Research
- T-cell and B-cell Immunology
- Parvovirus B19 Infection Studies
- COVID-19 Clinical Research Studies
- Cystic Fibrosis Research Advances
- Cytomegalovirus and herpesvirus research
- Ocular Surface and Contact Lens
- Cancer Immunotherapy and Biomarkers
- Congenital Ear and Nasal Anomalies
- Long-Term Effects of COVID-19
- Breast Lesions and Carcinomas
- Immune responses and vaccinations
- Genomic variations and chromosomal abnormalities
- Contact Dermatitis and Allergies
- Eosinophilic Esophagitis
- Chronic Lymphocytic Leukemia Research
Selçuk University
2016-2025
Selçuk Üniversitesi Tıp Fakültesi Hastanesi
2019-2024
ENT and Allergy
2022
Cukurova University
2020
London North West Healthcare NHS Trust
2020
Konya Food and Agriculture University
2020
Sağlık Bilimleri Üniversitesi
2020
Izmir University
2020
Istanbul University
2020
Increased levels of acute-phase reactants and lymphopenia are predictors disease severity in coronavirus 2019 (COVID-19). This study aimed to investigate the role apoptosis etiology patients with COVID-19. multicentered, prospective, case-control was conducted polymerase chain reaction (+) severe acute respiratory syndrome 2 (SARS-CoV-2) patients, an age-gender-matched control group. Samples were taken at time diagnosis analyzed via flow cytometry within 24 h. The participants' demographic...
One of the severe combined immunodeficiencies (SCIDs), which is caused by a genetic defect in signal transduction pathways involved T-cell activation, ZAP70 deficiency. Mutations lead to both abnormal thymic development and defective receptor (TCR) signaling peripheral T-cells. In contrast lymphopenia most SCID patients, ZAP70-deficient patients have lymphocytosis, despite selective absence CD8+ The clinical presentation usually before 2 years age with typical findings SCID. Here, we present...
Abstract Background Genetic deficiencies of immune system, referred to as inborn errors immunity (IEI), serve a valuable model study human responses. In multicenter prospective cohort, we evaluated the outcome SARS‐CoV‐2 infection among IEI subjects and analyzed genetic characteristics that determine adverse COVID‐19 outcomes. Methods We studied 34 patients (19M/15F, 12 [min: 0.6‐max: 43] years) from six centers. diagnosed by finding positive PCR test ( n = 25) and/or lung tomography scoring...
Keles S, Artac H, Kara R, Gokturk B, Ozen A, Reisli I. Transient hypogammaglobulinemia and unclassified hypogammaglobulinemia: ‘Similarities differences’.Pediatr Allergy Immunol 2010: 21: 843–851.© 2010 John Wiley & Sons A/S of infancy (THI) is characterized by recurrent infections one or more reduced serum immunoglobulin (Ig) levels. Usually, this clinical picture resolves spontaneously 3 yr age. However, persists until adolescence in some patients. In recent years, those patients have been...
The aim of this study was to evaluate the role T- and B-regulatory cells (Tregs Bregs) in pathogenesis idiopathic granulomatous mastitis (IGM).This includes 47 patients with pathologically proven IGM (Group P) 26 healthy subjects C). Group P were divided into two groups according whether their lesions active PA, n: 21) or remission PR, 26). By using flow-cytometry, frequencies CD3+CD4+CD45RA-Foxp3high activated Tregs (aTregs), CD3+CD4+CD45RA-Foxp3low non-suppressive Tregs,...
ABSTRACT Acute generalized exanthematous pustulosis (AGEP) is a severe adverse cutaneous reaction characterized by the rapid development of nonfollicular sterile pustules on an erythematous base. AGEP drug induced in 90% cases but has been associated with viral infections. This report describes rare case parvovirus B19 infection pediatric patient.
Monogenic immune dysregulation diseases (MIDD) are caused by defective immunotolerance. This study was designed to increase knowledge on the prevalence and spectrum of MIDDs, genetic patterns, outcomes in Middle East North Africa (MENA). MIDD patients from 11 MENA countries (Iran, Turkey, Kuwait, Oman, Algeria, Egypt, United Arab Emirates, Tunisia, Jordan, Qatar, Azerbaijan) were retrospectively evaluated. 343 (58% males 42% female) at a median (IQR) age 101 (42-192) months enrolled. The...
The aim of the study was to determine effects zinc and melatonin supplements on immunity parameters female rats with breast cancer induced by DMBA.Group 1; Control, Group 2; 7,12-dimethylbenz[a]anthracene (DMBA), 3; DMBA + zinc, 4; melatonin, 5; melatonin. rats' 80 mg/kg. Groups 3-5 received daily 5 mg/kg doses respectively. Lymphocyte rates, T-lymphocyte subgroups, B-lymphocyte natural killer cells (NK), T (NKT) were evaluated.The most significant increase in lymphocyte, T-lymphocyte, CD4...
This study analyzed peripheral blood lymphocyte subsets to determine their role in the etiopathogenesis of IGM.This includes 51 pathologically proven IGM patients (active disease: 26 and remission: 25) 28 healthy volunteers. The analyses were performed by flow cytometric immunophenotyping.The percentage T helper all lower than control groups (p = 0.001). Absolute cytotoxic count 0.03), both 0.035) absolute 0.002) natural killer cells, 0.038) 0.008) higher group. with active disease was group...
The patients with CD3γ deficiency can present different clinical findings despite having the same homozygous mutation. We report three new CD3gamma-deficient siblings from a consanguineous family combined T-B+NK+ immunodeficiency and their variable cellular phenotypes mutation of CD3G gene (c.80-1G>C). also re-evaluate previously reported non-consanguineous two median age at diagnosis was 11 years (14 months-20 years). found all five to display autoimmunity: autoimmune thyroiditis (n = 5),...
Abstract Background Dedicator of cytokinesis 8 (DOCK8) deficiency is the main cause autosomal recessive hyper‐IgE syndrome (HIES). We previously reported selective loss group 3 innate lymphoid cell (ILC) number and function in a Dock8 ‐deficient mouse model. In this study, we sought to test whether DOCK8 required for maintenance ILC subsets humans. Methods Peripheral blood ILC1‐3 16 DOCK8‐deficient patients recruited at pretransplant stage, seven with dominant (AD) HIES due STAT3 mutations,...
To evaluate serum 25-hydroxyvitamin D [25(OH)D3] levels of vernal keratoconjunctivitis (VKC) children.A total 62 non-atopic healthy children (64.5% male, mean age 10.79 ± 3.3 years) and 29 VKC (75.9%, 12.17 2.7 were included in the study. Serum 25(OH)D3 measured by HPLC compared between two groups a p value <0.05 was considered as statistically significant.The level group significantly lower than control (11.02 5.16 ng/mL 15.99 7.36 ng/mL, respectively) (p = 0.002). Severe vitamin deficiency...