A5102931158- Lipid Membrane Structure and Behavior
- MicroRNA in disease regulation
- RNA and protein synthesis mechanisms
- Lipid metabolism and biosynthesis
- RNA modifications and cancer
- Protein Structure and Dynamics
- Yersinia bacterium, plague, ectoparasites research
- Cancer-related molecular mechanisms research
- Chromosomal and Genetic Variations
- Gut microbiota and health
- Bacillus and Francisella bacterial research
- RNA Interference and Gene Delivery
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- Congenital Ear and Nasal Anomalies
- Head and Neck Cancer Studies
- Natural product bioactivities and synthesis
- Bacteriophages and microbial interactions
- Spectroscopy and Quantum Chemical Studies
- Immune Cell Function and Interaction
- Genomic variations and chromosomal abnormalities
- Sphingolipid Metabolism and Signaling
- Bacterial Genetics and Biotechnology
- Membrane Separation Technologies
- Metabolomics and Mass Spectrometry Studies
Basil Hetzel Institute
2024
Queen Elizabeth Hospital
2024
Central Adelaide Local Health Network
2024
The University of Adelaide
2024
Baylor College of Medicine
2016-2021
Texas Children's Hospital
2018
Oklahoma State Department of Health
2015
Occidental College
2009-2014
Wadsworth Center
2007-2013
New York State Department of Health
2013
During eukaryotic transcription elongation, RNA polymerase II (RNAP2) is regulated by a chorus of factors. Here, we identified common binary interaction module consisting TFIIS N-terminal domains (TNDs) and natively unstructured TND-interacting motifs (TIMs). This was conserved among the elongation machinery linked complexes including factor TFIIS, Mediator, super complex, elongin, IWS1, SPT6, PP1-PNUTS phosphatase, H3K36me3 readers, other Using nuclear magnetic resonance, live-cell...
MicroRNA (miRNA) deregulation in prostate cancer (PCa) contributes to PCa initiation and metastatic progression. To comprehensively define the cancer-associated changes miRNA targeting function commonly studied models of PCa, we performed photoactivatable ribonucleoside-enhanced cross-linking immunoprecipitation Argonaute protein a panel cell lines modeling different stages Using this comprehensive catalogue targets, analyzed on known drivers examined tissue-specific stage-specific pathway...
Yersinia pestis, the etiologic agent of plague, is closely related to pseudotuberculosis evolutionarily but has a very different mode infection. The RNA-binding regulatory protein, Hfq, mediates regulation by small RNAs (sRNAs) and required for virulence both Y. pestis pseudotuberculosis. Moreover, Hfq growth not pseudotuberculosis, at 37°C. Together, these observations suggest that sRNAs play important roles in survival may account some differences between We have used deep sequencing...
Abstract Intrinsically disordered proteins (IDPs) or unstructured segments within play an important role in cellular physiology and pathology. Low concentration, multiple binding partners, frequent post-translational modifications the presence of conformations make it difficult to characterize IDP interactions intact cells. We used peptide aptamers selected by using yeast-two-hybrid scheme in-cell NMR identify high affinity binders transiently structured at atomic resolution. Since both...
Abstract SETD2 contributes to gene expression by marking bodies with H3K36me3, which is thought assist in the concentration of transcription machinery at small portion coding genome. Despite extensive genome-wide data revealing precise localization H3K36me3 over bodies, physical basis for accumulation, maintenance, and sharp borders these sites remains rudimentary. Here we propose a model based on stochastic transcription-dependent placement transcription-independent spreading. Our analysis...
Abstract SWI/SNF and related chromatin remodeling complexes act as tissue-specific tumor suppressors are frequently inactivated in different cancers. Although many regulatory activities of have been identified using 2D cell culture, the effects alterations more complex 3D tissues remained poorly understood. Here we employed culture conditions that yield transcriptomic states mirroring primary lung adenocarcinoma (LUAD) specimens better than culture. By analyzing spatial patterns gene...