About
Contact & Profiles
A5067537097
Research Areas
- Genetics and Neurodevelopmental Disorders
- Ubiquitin and proteasome pathways
- Endoplasmic Reticulum Stress and Disease
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- RNA Research and Splicing
Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry
2021-2024
Charles University
2024
During eukaryotic transcription elongation, RNA polymerase II (RNAP2) is regulated by a chorus of factors. Here, we identified common binary interaction module consisting TFIIS N-terminal domains (TNDs) and natively unstructured TND-interacting motifs (TIMs). This was conserved among the elongation machinery linked complexes including factor TFIIS, Mediator, super complex, elongin, IWS1, SPT6, PP1-PNUTS phosphatase, H3K36me3 readers, other Using nuclear magnetic resonance, live-cell...
10.1126/science.abe2913
article
EN
Science
2021-11-25
10.1016/j.isci.2024.110893
article
EN
cc-by-nc
iScience
2024-09-06
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