A5031112242- CAR-T cell therapy research
- Cancer Research and Treatments
- 3D Printing in Biomedical Research
- Immunotherapy and Immune Responses
- Tissue Engineering and Regenerative Medicine
- Nanoparticle-Based Drug Delivery
- Virus-based gene therapy research
- Nanoplatforms for cancer theranostics
- Immune Cell Function and Interaction
- Electrospun Nanofibers in Biomedical Applications
- Viral Infections and Immunology Research
- MicroRNA in disease regulation
- Sarcoma Diagnosis and Treatment
- RNA modifications and cancer
- Immune cells in cancer
- Diet and metabolism studies
- Neuroblastoma Research and Treatments
- Advanced Drug Delivery Systems
- Pluripotent Stem Cells Research
- Advanced biosensing and bioanalysis techniques
- Adipose Tissue and Metabolism
- Chromatin Remodeling and Cancer
- Curcumin's Biomedical Applications
- Congenital heart defects research
- Analytical Chemistry and Chromatography
Rice University
2018-2023
Lonza (United States)
2023
Bridge University
2022
Baylor College of Medicine
2022
Baylor University
2022
University of California, Santa Barbara
2016-2018
Seagate (United States)
2001
Proinflammatory cytokines have been approved by the Food and Drug Administration for treatment of metastatic melanoma renal carcinoma. However, effective cytokine therapy requires high-dose infusions that can result in antidrug antibodies and/or systemic side effects limit long-term benefits. To overcome these limitations, we developed a clinically translatable delivery platform composed polymer-encapsulated human ARPE-19 (RPE) cells produce natural cytokines. Tumor-adjacent administration...
Fibrosis remains a significant cause of failure in implanted biomedical devices and early absorption proteins on implant surfaces has been shown to be key instigating factor. However, lipids can also regulate immune activity their presence may contribute biomaterial-induced foreign body responses (FBR) fibrosis. Here it is demonstrated that the surface presentation affects FBR by influencing reactions cells materials as well resultant inflammatory/suppressive polarization. Time-of-flight...
Immune modulatory alginate encapsulation platform can be used in the pericardial space to provide enhanced therapeutic efficacy heart.
In vitro and in vivo assessment of safety efficacy are the essential first steps developing nanoparticle-based therapeutic systems. However, it is often challenging to use knowledge gained from studies predict outcome since complexity environment, including existence flow a multicellular lacking traditional models. Here, we describe microfluidic co-culture model comprising 4T1 breast cancer cells EA.hy926 endothelial under physiological conditions its utilization assess penetration...
Surface modification of nanoparticles is a well-established methodology to alter their properties enhance circulation half-life. While literature studies using conventional, in vitro characterization are routinely used evaluate the biocompatibility such modifications, relatively little attention has been paid assess stability surface modifications physiologically relevant conditions. Here, microfluidic devices were study effect factors that adversely impact including vascular flow and...
Abstract SWI/SNF and related chromatin remodeling complexes act as tissue-specific tumor suppressors are frequently inactivated in different cancers. Although many regulatory activities of have been identified using 2D cell culture, the effects alterations more complex 3D tissues remained poorly understood. Here we employed culture conditions that yield transcriptomic states mirroring primary lung adenocarcinoma (LUAD) specimens better than culture. By analyzing spatial patterns gene...
Abstract Biomaterials induced host immune responses, and fibrotic overgrowth remains a major barrier to the long-term function of medical devices biomaterial consisting tissue grafts. Screening new biomaterials identify anti-fibrotic formulation requires in vivo testing, which is challenging multiplex significant obstacle progress this field. Herein, we synthesized combinatorial chemically modified hydrogel library developed cellular barcoding method that enables high-throughput multiplexed...
Biomaterials In article number 2205709, Christian C. Schreib, Omid Veiseh, and co-workers explore how lipid deposition affects the way body responds to implanted biomaterials. They discover that certain types of phospholipids tend accumulate on immune-evasive implants, while different sets fatty acid lipids deposit immunogenic implants. These directly impact transcriptome macrophages found surface implant materials.
<h3>Background</h3> IL-2 have been approved by the FDA for treatment of metastatic melanoma and renal carcinoma. However, potent effective pharmacological activity is limited its short half-life in circulation severe adverse effects associated with high systemic exposure. To overcome toxicities administration, intraperitoneal (IP) administration cytokines has studied multiple cancer types. In one study, IP ovarian (n=24) patients resulted an ORR 25% (4 complete, 2 partial responses). use...
Abstract Adeno-associated virus (AAV) vector-based gene therapies can be applied to a wide range of diseases. AAV expression last for months years, but vector re-administration may necessary achieve life-long treatment. Unfortunately, immune system response against these vectors is potentiated after the first administration, which prevents clinical use repeated administration AAVs. Reducing AAVs while minimizing immunosuppression would improve delivery efficiency and long-term safety. In...
<h3>Background</h3> Aldesleukin, recombinant human IL-2 has been approved by the FDA for treatment of melanoma and renal cancer. However, effective cytokine therapy is limited its short half-life in circulation severe adverse effects associated with high systemic exposure when administered iv. To overcome these limitations, Avenge Bio developed a localized delivery LOCOcyte<sup>TM</sup> platform comprised polymer encapsulated epithelial cells that produce potent immune effector molecules...
Abstract Recombinant IL-2 has been approved for the treatment of melanoma and renal cancer. However, therapy is limited by its short half-life in circulation associated toxicities that emerge as a result high systemic exposure. To overcome these limitations, we developed localized cytokine LOCOcyteTM platform composed allogeneic engineered cells which produce potent immune effector molecules local delivery with temporal regulation activity. Administration AVB-001 mice non-human primates...
Background Pro-inflammatory cytokines have been approved by the FDA for treatment of metastatic melanoma and renal carcinoma. 1 2 However, effective cytokine therapy is limited its short half-life in circulation severe adverse effects associated with high systemic exposure. 3 To overcome these limitations, we developed a clinically translatable localized delivery platform composed polymer encapsulated epithelial cells that produce natural (IL2, IL7, IL10, or IL12) temporal regulation....