In vitro and in vivo assessment of safety efficacy are the essential first steps developing nanoparticle-based therapeutic systems. However, it is often challenging to use knowledge gained from studies predict outcome since complexity environment, including existence flow a multicellular lacking traditional models. Here, we describe microfluidic co-culture model comprising 4T1 breast cancer cells EA.hy926 endothelial under physiological conditions its utilization assess penetration...

Patients with chronic obstructive pulmonary disease receive a range of treatments including but not limited to inhaled bronchodilators, and systemic corticosteroids, supplemental oxygen, rehabilitation. Pulmonary rehabilitation is multidisciplinary intervention that seeks combine patient education, exercise, lifestyle changes into comprehensive program. Programs 6 8 weeks in length have been shown improve health, reduce dyspnea, increase exercise capacity, psychological well-being,...

Background: COPD exacerbations occur more frequently with disease progression and are associated worse prognosis higher healthcare expenditure. Purpose: To utilize a networked system, optimized statistical process control (SPC), for remote patient monitoring (RPM) to identify potential predictors of exacerbations. Methods: Seventeen subjects, mean (SD) age 69.7 (7.2) years, moderate severe received RPM. Over 2618 patient-days (7.17 patient-years) monitoring, we obtained daily symptom scores,...

Surface modification of nanoparticles is a well-established methodology to alter their properties enhance circulation half-life. While literature studies using conventional, in vitro characterization are routinely used evaluate the biocompatibility such modifications, relatively little attention has been paid assess stability surface modifications physiologically relevant conditions. Here, microfluidic devices were study effect factors that adversely impact including vascular flow and...

Abstract Background Cemented endoprosthetic reconstruction after resection of primary bone sarcomas has been in common use for decades. Although multiple studies have reported the survivorship endoprostheses, implant revision surgery is less well established. Given that earlier advances systemic therapy improved survival patients with sarcoma, usage endoprostheses can be expected to increase and, as such, understanding will help inform patient and surgeon expectations. Additionally, new...

The demand for efficient and effective exercises has grown in concert with increased attention to fitness as a determinant of overall health. While past studies have examined the benefits traditional conditioning exercises, there been few investigations high intensity functional training (HIFT). aim this study was measure energy expenditure relative from participation signature, 35-minute group-based HIFT regimen. During session, 13 volunteers (aged 23-59 years, 6 females) donned portable...

Aims Delayed postoperative inoculation of orthopaedic implants with persistent wound drainage or bacterial seeding a haematoma can result in periprosthetic joint infection (PJI). The aim this vivo study was to compare the efficacy vancomycin powder vancomycin-eluting calcium sulphate beads preventing PJI due delayed inoculation. Methods A mouse model knee used. Mice were randomized into groups intervention at time surgery (postoperative day (POD) 0): sterile control (SC; n = 6); infected...

Thoracic outlet syndrome (TOS) is a rare injury that affects Major League Baseball (MLB) pitchers and often corrected with surgical resection of the first rib. There are limited return-to-play (RTP) data for this surgery in MLB pitchers.It was hypothesized who undergo rib TOS will show (1) high rate RTP, (2) no difference postoperative career length compared controls, (3) pre- performance, (4) performance controls.Cohort study; Level evidence, 3.This retrospective cohort study evaluated...

Abstract Background The durability of endoprostheses after limb salvage surgery is influenced by surgical factors (resection length, implant location, and residual bone quality), design (modular versus custom design, rotating fixed hinge, coating, collars, the use cross pins), host (patient’s immune status, activity levels, age). In general, radiation therapy increases risk fractures, infection, delayed wound healing, impaired osseointegration. Several studies have shown exposure to be...

Objective: To measure metabolic and physiological demand, subjective fatigue, enjoyment during a signature 30-minute immersive virtual reality (IVR) adaptive cable resistance exergaming session. Methods: Fourteen healthy college-aged individuals (seven females) were initially acquainted with the IVR equipment gameplay dynamics. Participants then underwent session performing six different exercises. A portable gas exchange analyzer concurrently assessed energy expenditure (EE) through...

Prior studies have examined the benefits of graduated compression garments (GCG) with regards to diverse exercise regimens; however, relationship between GCG and autonomic nervous system (ANS) has not been fully explored. The aim this study was examine Heart Rate Variability (HRV) trends-a proxy for ANS modulation-in response donning during a progressive overload training regimen designed induce overtraining. Ten college-aged male novice runners were recruited 8-week crossover study. After...

To evaluate whether preoperative magnetic resonance imaging (MRI) measurements of multiple tendon autograft sources could be used to improve estimates intraoperative hamstring (HTA) diameter.Patients who underwent anterior cruciate ligament reconstruction with HTA at our institution were identified through electronic health records. Preoperative MRI the patellar (PT) length, PT width, thickness, quadriceps semitendinosus (ST) cross-sectional area (CSA), and gracilis (GT) CSA conducted by 2...

Analysis of metabolic gas exchange and muscular output measures have enabled researchers to index activity intensity energy expenditure for a myriad exercises. However, there is no current research that investigates the physiological demands riding electrically powered skateboards. The aim this study was measure energetic cost trends novel skateboard engineered emulate snowboarding on dry-land. While skateboard, eight participants (aged 21-37 years, 1 female) donned portable breath-by-breath...

PURPOSE: To determine the rates of return to play (RTP) and performance changes Major League Baseball (MLB) pitchers after undergoing rib resection surgery for treatment thoracic outlet syndrome (TOS). The authors hypothesized that players would have high RTP with no significant differences in performance. METHODS: MLB from 2000 2019 seasons were included. Inclusion criteria included at least one season played prior 18 months time end study period. was defined as playing game surgery....

<sec> <title>BACKGROUND</title> The intersection of games and exercise has sparked the growth novel training systems with potential to promote quality physical activity. Innovations in Immersive Virtual Reality (IVR) have propelled “exergaming” forefront fitness landscape. Researchers yet fully explore physiological metabolic efficacy applications immersive environment interactive programming. </sec> <title>OBJECTIVE</title> This study aimed measure (i.e., energy expenditure (EE)) heart rate...