A5100713904- Thermoregulation and physiological responses
- Heart Rate Variability and Autonomic Control
- Exercise and Physiological Responses
- T-cell and B-cell Immunology
- Sports Performance and Training
- Cancer Immunotherapy and Biomarkers
- Hemodynamic Monitoring and Therapy
- Muscle metabolism and nutrition
- Cardiovascular Syncope and Autonomic Disorders
- Cancer survivorship and care
- Non-Invasive Vital Sign Monitoring
- Cardiovascular and exercise physiology
- Atherosclerosis and Cardiovascular Diseases
- Immune Cell Function and Interaction
- Climate Change and Health Impacts
- Systemic Lupus Erythematosus Research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cardiac Arrest and Resuscitation
- Ecology and Vegetation Dynamics Studies
- Clinical practice guidelines implementation
- Immunotherapy and Immune Responses
- Fire effects on ecosystems
- Sports injuries and prevention
- Infrared Thermography in Medicine
- Psoriasis: Treatment and Pathogenesis
St James's University Hospital
2019-2024
University of Leeds
2017-2024
Kijabe Hospital
2023
Queen Elizabeth University Hospital
2022
The University of Texas Health Science Center at San Antonio
2021
Pacific University
2021
University of California, Los Angeles
2020
United States Army Institute of Surgical Research
2014-2019
St. Jude Children's Research Hospital
2018-2019
Texas Biomedical Research Institute
2019
Electronic patient self-Reporting of Adverse-events: Patient Information and aDvice (eRAPID) is an online eHealth system for patients to self-report symptoms during cancer treatment. It provides automated severity-dependent advice guiding self-management or medical contact displays the reports in electronic records. This trial evaluated impact eRAPID on symptom control, healthcare use, self-efficacy, quality life (QOL) a population treated predominantly with curative intent.Patients...
This report demonstrates that the investigational prostatic carcinoma marker known as prostate-specific membrane antigen (PSM) possesses hydrolytic activity with substrate and pharmacologic properties of N-acetylated alpha-linked acidic dipeptidase (NAALADase). NAALADase is a hydrolase has been characterized in mammalian nervous system on basis its catabolism neuropeptide N-acetylaspartylglutamate (NAAG) to yield glutamate N-acetylaspartate hypothesized influence glutamatergic signaling...
Studies have suggested that sickle cell trait elevates the risks of exertional rhabdomyolysis and death. We conducted a study in relation to these outcomes, controlling for known risk factors rhabdomyolysis, large population active persons who had undergone laboratory tests hemoglobin AS (HbAS) were subject exertional-injury precautions.We used Cox proportional-hazards models test whether death varied according status among 47,944 black soldiers testing HbAS on duty U.S. Army between January...
This study compared the effects of hypohydration (HYP) on endurance exercise performance in temperate and cold air environments. On four occasions, six men two women (age = 24 ± 6 yr, height 170 cm, weight 72.9 11.1 kg, peak O 2 consumption 48 9 ml·kg −1 ·min ) were exposed to 3 h passive heat stress (45 °C) early morning with [euhydration (EUH)] or without (HYP; 3% body mass) fluid replacement. Later day, subjects sat a (2 (20 environment minimal clothing for 1 before performing 30 min...
The purpose of this study was to quantify the variability and stability 1st morning body mass (BM) fluctuations during daily exercise in heat while following traditional fluid intake guidance. Data from 65 men were examined retrospectively. BM monitored over 4 15 consecutive days. Group variation 0.51+/-0.20 kg. coefficient 0.66+/-0.24%, normally distributed, not related either absolute (r = 0.04) or number measurements 0.34). Three days resulted a similar estimate compared 6 9 d, although...
Patients undergoing major cancer surgery frequently require post-acute care for complications and adverse effects. Enhanced recovery after programmes mean that patients are increasingly discharged home earlier. Symptom/complication detection post-discharge is sub-optimal. Systematic patient monitoring following may be optimally achieved through routine electronic patient-reported outcome (ePRO) data capture. ePRO systems employ clinical algorithms to guide management of automatically alert...
We sought to determine the relative contributions of cessation skeletal muscle pumping and withdrawal central command rapid decrease in arterial pressure during recovery from exercise. Twelve healthy volunteers underwent three exercise sessions, each consisting a warm-up, 3 min cycling at 60% maximal heart rate, 5 one following modes: seated (inactive), loadless pedaling (active), passive cycling. Mean (MAP), cardiac output, thoracic impedance, rate were measured. When measured 15 s after...
Obstructive sleep apnea (OSA) consists of repetitive choking spells due to sleep-induced reduction upper airway muscle tone. Millions adults and children live unaware this condition, which can have a profound affect on their health quality life. Obesity, gender, genetic, hormonal factors mediate risk for OSA interact in multifaceted manner the pathogenesis disease. Obesity is most established primary factor given that body mass index, visceral fat, neck circumference are major predictors...
This study examined the effects of hypohydration and moderate hyperthermia (core temperature elevation) on anaerobic exercise performance in a temperate environment.Eight active males completed two passive heat exposure trials (180 min, 45 degrees C, 50% rh) with (EUH) without (HYP) fluid replacement. A single 15-s Wingate test (WAnT) was used to assess (peak power, mean fatigue index) before (-180 min) again at three time points after include immediately (0 min), 30 60 min environment (22...
The serotonin system may contribute to reduced human performance when hypohydrated in the heat. This study determined whether branched-chain amino acid (BCAA) supplementation could sustain exercise and cognitive heat (40 degrees C dry bulb, 20% relative humidity) by 4% of body mass. Seven heat-acclimated men completed two experimental trials, each consisting one preparation test day. On day 1, a low-carbohydrate diet was eaten subjects performed exhaustive cycling (morning) treadmill...
High tolerance to progressive reductions in central blood volume has been associated with higher heart rate (HR), peripheral vascular resistance (PVR), sympathetic nerve activity (SNA), and vagally mediated cardiac baroreflex sensitivity (BRS). Using a database of 116 subjects classified as high presyncopal-limited lower body negative pressure (LBNP), we tested the hypothesis that greater withdrawal (i.e., BRS > 1.0) would demonstrate LBNP HR, PVR, SNA. Subjects underwent presyncope. Mean...
Background Cancer is treated using multiple modalities (e.g. surgery, radiotherapy and systemic therapies) frequently associated with adverse events that affect treatment delivery quality of life. Regular event reporting could improve care safety through timely detection management. Information technology provides a feasible monitoring model, but applied research needed. This programme developed evaluated an electronic system, called eRAPID, for cancer patients to remotely self-report...
Rhabdomyolysis (RM) is a skeletal muscle disorder resulting in severe cellular injury caused by vigorous physical activity and other systemic etiologies. RM associated with significant morbidity, such as acute renal failure, can be fatal. that occurs the US Active Duty Army (ADA) results time lost from training, deployment, combat. We sought to systemically describe epidemiology of ADA clinical quantifying terms absolute numbers, examine rate trends, identify soldiers at elevated risk.We...
<b><i>Background:</i></b> Sarcoidosis is a chronic inflammatory disease of unknown etiology, which can involve different organs and systems. Accordingly, sarcoidosis mimic breast cancer, making the differential diagnosis very difficult. <b><i>Case Report:</i></b> 5 patients with both cancer followed by Rabin Medical Center between January 1993 June 2012 were enrolled in this study. Additionally, comprehensive literature review identified 104...
BACKGROUND During traumatic hemorrhage, the ability to identify shock and intervene before decompensation is paramount survival. Lactate extremely sensitive shock, its clearance has been demonstrated a useful gauge of resuscitation status. Though lactate can be measured in field, logistical constraints render it impractical certain environments. The compensatory reserve represents new clinical measurement reflecting remaining capacity compensate for hypoperfusion. We hypothesized index (CRI)...
Severe dengue hemorrhagic fever (DHF) is a viral infection that acts to increase permeability of capillaries, resulting in internal hemorrhage. Linear frequency domain Fourier spectral analysis represents the most published noninvasive tool for diagnosing and assessing health status via calculated heart rate variability (HRV). As such, HRV may be useful clinical DHF patients, but prone erroneous results conclusions due influence average HR during time period assessment (defined as...
Are women more susceptible to acute postexercise orthostatic hypotension compared with men? We hypothesized that decreases in arterial pressure during recovery from dynamic exercise are greater men. studied 8 men and 11 inactive active cycling exercise. Heart rate, stroke volume (SV), cardiac output, mean (MAP), total peripheral resistance (TPR) were measured after 3 min of at 60% calculated maximum heart rate. At 1 exercise, MAP decreased less ( P < 0.05) (−18 ± 2 mmHg) (−30 mmHg). This...
To identify the effects of exercise recovery mode on cutaneous vascular conductance (CVC) and sweat rate, eight healthy adults performed two 15-min bouts upright cycle ergometry at 60% maximal heart rate followed by either inactive or active (loadless pedaling) recovery. An index CVC was calculated from ratio laser-Doppler flux to mean arterial pressure. then expressed as a percentage maximum (%max) determined local heating. At 3 min postexercise, greater during (chest: 40 ± 3, forearm: 48...
The purpose of this study was to identify whether baroreceptor unloading responsible for less efficient heat loss responses (i.e., skin blood flow and sweat rate) previously reported during inactive compared with active recovery after upright cycle exercise (Carter R III, Wilson TE, Watenpaugh DE, Smith ML, Crandall CG. J Appl Physiol 93: 1918-1929, 2002). Eight healthy adults performed two 15-min bouts supine followed by or (no-load pedaling) recovery. Core temperature (T(core)), mean...
New Findings What is the central question of this study? The negative intrathoracic pressure created by inspiration (i.e. respiratory pump) associated with enhanced venous return, although its contribution as a potential mechanism compensation during blood loss has not been quantified. main finding and importance? We demonstrated that optimizing creation represented haemorrhage was quantifiably reflected in reduced rate diminution compensatory reserve, resulting increased tolerance to...