A5028743743- Muscle metabolism and nutrition
- Metabolism and Genetic Disorders
- Growth Hormone and Insulin-like Growth Factors
- Metabolomics and Mass Spectrometry Studies
- High Altitude and Hypoxia
- Exercise and Physiological Responses
- Diet and metabolism studies
- Neonatal Health and Biochemistry
- Sports Performance and Training
- Obesity, Physical Activity, Diet
- Child Nutrition and Water Access
- Nicotinic Acetylcholine Receptors Study
- Infant Nutrition and Health
- Folate and B Vitamins Research
- Child Nutrition and Feeding Issues
- Adipose Tissue and Metabolism
- Birth, Development, and Health
- Smoking Behavior and Cessation
- Coffee research and impacts
- Adrenal Hormones and Disorders
- Clinical Nutrition and Gastroenterology
- Heavy Metal Exposure and Toxicity
- Antibiotics Pharmacokinetics and Efficacy
- Thyroid Disorders and Treatments
- Spaceflight effects on biology
Boston Children's Hospital
2016-2025
Harvard University
2015-2025
Boston Children's Museum
2011-2024
U.S. Army Research Institute of Environmental Medicine
2001-2018
MetaMetrics (United States)
2018
United States Army
2001-2014
Kellogg's (Canada)
2014
University of Connecticut
2013
Harvard University Press
2012-2013
Ames Research Center
2012
Sugar-sweetened beverage consumption is associated with weight gain and risk of type 2 diabetes mellitus. Few studies have tested for a relationship coronary heart disease (CHD) or intermediate biomarkers. The role artificially sweetened beverages also unclear.We performed an analysis the Health Professionals Follow-Up Study, prospective cohort study including 42 883 men. Associations cumulatively averaged sugar-sweetened (eg, sodas) diet intake incident fatal nonfatal CHD (myocardial...
While circulating levels of soluble Intercellular Adhesion Molecule 1 (sICAM-1) have been associated with diverse conditions including myocardial infarction, stroke, malaria, and diabetes, comprehensive analysis the common genetic determinants sICAM-1 is not available. In a genome-wide association study conducted among 6,578 participants in Women's Genome Health Study, we find that three SNPs at ICAM1 (19p13.2) locus (rs1799969, rs5498 rs281437) are non-redundantly plasma concentrations...
Compared to soy, whey protein is higher in leucine, absorbed quicker and results a more pronounced increase muscle synthesis.Objective: To determine whether supplementation with promotes greater increases mass compared soy or carbohydrate, we randomized non-resistance-trained men women into groups who consumed daily isocaloric supplements containing carbohydrate (carb; n = 22), (whey; 19), (soy; 22).Methods: All subjects completed supervised, whole-body periodized resistance training program...
To determine the diagnostic accuracy of a rapid host-protein test for differentiating bacterial from viral infections in patients who presented to emergency department (ED) or urgent care center (UCC).
OBJECTIVE: To explore the relationship between tobacco smoke exposure (reported versus biomarker) and rates of readmission for children hospitalized asthma. METHODS: We enrolled a prospective cohort 774 aged 1 to 16 years admitted asthma or bronchodilator-responsive wheezing. The primary outcome was at least asthma- wheeze-related within year. Caregivers reported any home, in secondary residence, car. measured serum saliva cotinine levels with mass spectrometry. used logistic regression...
This study evaluated the individual components of insulin-like growth factor I (IGF-I) system [i.e., total and free IGF-I, binding protein (IGFBP)-2 -3, acid-labile subunit (ALS)] in 10 young, healthy men (age: 22 ± 1 yr, height: 177 2 cm, weight: 79 3 kg, body fat: 11 1%) overnight for 13 h after two conditions: a resting control (Con) an acute, heavy-resistance exercise protocol (Ex). The Ex was high-volume, multiset that alternated between 10- 5-repetition maximum sets with 90-s rest...
This investigation determined if 3 levels of controlled caffeine consumption affected fluid-electrolyte balance and renal function differently. Healthy males (mean ± standard deviation; age, 21.6 3.3 y) consumed mg · kg −1 d on days 1 to 6 (equilibration phase). On 7 11 (treatment phase), subjects either 0 (C0; placebo; n = 20), (C3; or (C6; 19) in capsules, with no other dietary intake. The following variables were unaffected ( P > 0.05) by different doses 1, 3, 6, 9, within normal...
Insulin-like growth factor (IGF)-I is a biomarker that may have greater utility than other conventional nutritional biomarkers in assessing nutritional, health, and fitness status. We hypothesized the IGF-I system would directionally track short-term energy deficit be more related to changes body composition biomarkers. Thirty-five healthy men (24 +/- 0.3 yr) underwent 8 days of exercise imbalance. Total free IGF-I, IGF binding proteins-1, -2, -3, acid labile subunit, transferrin, ferritin,...
Energy restriction coupled with high energy expenditure from arduous work is associated an altered insulin-like growth factor-I (IGF-I) system and androgens that are coincident losses of fat-free mass. The aim this study was to determine the effects two levels dietary protein content its on IGF-I, androgens, mass accompanying deficit. We hypothesized higher would attenuate decline anabolic hormones and, thus, prevent Thirty-four men [24 (SD 0.3) yr, 180.1 1.1) cm, 83.0 1.4) kg] participated...
Whey protein intake reduces CVD risk, but little is known whether whey-derived bioactive peptides regulate vascular endothelial function (VEF). We determined the impact of a extract (NOP-47) on VEF in individuals with an increased cardiovascular risk profile. Men and women impaired brachial artery flow-mediated dilation (FMD) ( n 21, age 55 sem 1·3) years, BMI 27·8 0·6) kg/m 2 , FMD 3·7 0·4) %) completed randomised, cross-over study to examine ingestion NOP-47 (5 g) improves postprandial...
Neosaxitoxin (NeoSTX) is a site-1 sodium channel blocker that produces prolonged local anesthesia in animals and humans. Under Food Drug Administration-approved phase 1 Investigational New trial, the authors evaluated safety efficacy of NeoSTX alone combined with 0.2% bupivacaine (Bup) without epinephrine.The conducted double-blind, randomized, controlled trial involving healthy male volunteers aged 18 to 35 yr receiving two 10-ml subcutaneous injections. Control sites received Bup. In part...
Journal Article Interlaboratory comparability of serum cotinine measurements at smoker and nonsmoker concentration levels: A round-robin study Get access John T. Bernert, Bernert Search for other works by this author on: Oxford Academic PubMed Google Scholar Peyton Jacob, Jacob David B. Holiday, Holiday Neal L. Benowitz, Benowitz Connie S. Sosnoff, Sosnoff Mira V. Doig, Doig Colin Feyerabend, Feyerabend Kenneth M. Aldous, Aldous Mehran Sharifi, Sharifi Mark D. Kellogg, Kellogg ... Show more...
The serotonin system may contribute to reduced human performance when hypohydrated in the heat. This study determined whether branched-chain amino acid (BCAA) supplementation could sustain exercise and cognitive heat (40 degrees C dry bulb, 20% relative humidity) by 4% of body mass. Seven heat-acclimated men completed two experimental trials, each consisting one preparation test day. On day 1, a low-carbohydrate diet was eaten subjects performed exhaustive cycling (morning) treadmill...
The cardiovascular effects of endothelin-1 (ET-1) in trout were examined unanesthetized fish, perfused tissues, and isolated vascular rings. In vivo, a bolus 500 ng/kg body wt ET-1 transiently lowered arterial (postgill) blood pressure (BP) by nearly 30%; 1,500 produced triphasic, pressor-depressor-pressor, response. Continuous infusion 0.1, 1, 10, 30 ng.kg-1.min-1 progressively BP but did not affect heart rate (HR), urine flow, or electrolyte excretion. the situ (10(-11) to 10(-8) M) had no...
Like caffeine, theobromine crosses the blood-brain barrier and binds to adenosine receptors, suggesting it might share caffeine's beneficial effects on mood vigilance. Therefore, purpose of this study was assess effect doses commonly found in foods vigilance parameters sensitive caffeine. Caffeine tested as a positive control. Twenty-four men (age, 23 [3] years) completed 6 double-blind trials during which they consumed experimental beverages, assessed their using standardized self-report...
Diagnosis and management of diabetic ketoacidosis (DKA) often rely on the measurement urine ketones along with blood glucose, anion gap, pH. These values, however, do not reliably reflect severity ketoacidosis. The Abbott Precision Xceed Pro® meter is an FDA-approved device that quantitatively measures β-hydroxybutyrate (BOH) in whole blood. This study was undertaken to determine whether ketone meets analytical criteria aid DKA diagnosis hospital.54 heparinized venous BOH concentrations from...
To develop age- and sex-specific RBC reference intervals using the National Health Nutrition Examination Survey (NHANES) 1999 to 2012, a large nationally representative, population-based, cross-sectional database (n = 44,328). Comprehensive medical data were used define "healthy" population. Reference for count, hemoglobin, hematocrit, mean cell hemoglobin concentration, volume, red distribution width computed piecewise regression, an evidence-based statistical procedure that identifies...
Abstract Global untargeted metabolomics (GUM) has entered clinical diagnostics for genetic disorders. We compared the utility of GUM with traditional targeted (TM) as a screening tool in patients established disorders and determined scope discovery no diagnosis under investigation. TM data 226 patients. The first cohort (n = 87) included confirmed inborn errors metabolism (IEM) syndromes; second 139) without who were undergoing evaluation disorder. In known 87), performed sensitivity 86%...