A5036156678- Cerebrospinal fluid and hydrocephalus
- Traumatic Brain Injury and Neurovascular Disturbances
- Spinal Dysraphism and Malformations
- Fetal and Pediatric Neurological Disorders
- Intracranial Aneurysms: Treatment and Complications
- Meningioma and schwannoma management
- Neonatal and fetal brain pathology
- Spinal Fractures and Fixation Techniques
- Epilepsy research and treatment
- Scoliosis diagnosis and treatment
- Head and Neck Surgical Oncology
- Electrospun Nanofibers in Biomedical Applications
- Trauma and Emergency Care Studies
- Pituitary Gland Disorders and Treatments
- Systemic Sclerosis and Related Diseases
- Bone Tumor Diagnosis and Treatments
- Trace Elements in Health
- Spine and Intervertebral Disc Pathology
- Cerebrovascular and genetic disorders
- Heavy Metal Exposure and Toxicity
- Glioma Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Child Abuse and Related Trauma
- Otolaryngology and Infectious Diseases
- Vasculitis and related conditions
Children's Hospital of Orange County
2024-2025
Loma Linda University
2020-2024
Neurological Surgery
2011-2024
Loma Linda University Medical Center
2024
University of Washington
2012-2021
University of Toronto
2019-2020
Hospital for Sick Children
2020
Smith College
2018
Syracuse University
2018
University of Memphis
2018
Meningomyelocele is one of the most severe forms neural tube defects (NTDs) and frequent structural birth defect central nervous system. We assembled Spina Bifida Sequencing Consortium to identify causes. Exome genome sequencing 715 parent-offspring trios identified six patients with chromosomal 22q11.2 deletions, suggesting a 23-fold increased risk compared general population. Furthermore, analysis separate deletion cohort suggested 12- 15-fold NTD meningomyelocele. The loss
Fibrosis remains a significant cause of failure in implanted biomedical devices and early absorption proteins on implant surfaces has been shown to be key instigating factor. However, lipids can also regulate immune activity their presence may contribute biomaterial-induced foreign body responses (FBR) fibrosis. Here it is demonstrated that the surface presentation affects FBR by influencing reactions cells materials as well resultant inflammatory/suppressive polarization. Time-of-flight...
Abstract Purpose Parry-Romberg syndrome (PRS) is a rare disorder characterized by slowly progressive hemifacial atrophy. Although the underlying etiology unknown, proposed disease mechanisms which include autoimmune, infection, trauma, and other causes have been as mechanisms. Approximately, 10–20% of PRS patients neurologic manifestations such epilepsy, headaches, or associated vascular malformations. There are reports responsive to immunosuppressive medications, supporting autoimmune...
OBJECTIVE Shunt obstruction by cells and/or tissue is the most common cause of shunt failure. Ventricular catheter alone accounts for more than 50% failures in pediatric patients. The authors sought to systematically collect explanted ventricular catheters from Seattle Children's Hospital with a focus on elucidating cellular mechanisms underlying obstruction. METHODS In operating room, hardware was placed 4% paraformaldehyde. Weekly, samples were transferred buffer solution and stored at...
The stroke rate, management, and outcome after blunt cerebrovascular occlusion (Biffl Grade IV injury) is not well defined, given the rarity of disease. Both hemodynamic failure embolic mechanisms have been implicated in pathophysiology subsequent occlusion. In this study, authors evaluated their center's experience with Biffl injuries, focusing on elucidating optimal management.A retrospective review identified all internal carotid artery (ICA) or vertebral (VA) injuries over a 7-year...
Abstract The majority of patients with hydrocephalus are dependent on ventriculoperitoneal shunts for diversion excess cerebrospinal fluid. Unfortunately, these failure‐prone and over half all life‐threatening pediatric failures caused by obstruction the ventricular catheter brain's resident immune cells, reactive microglia astrocytes. Poly(2‐hydroxyethyl methacrylate) (PHEMA) hydrogels widely used biomedical implants. extreme hydrophilicity PHEMA confers resistance to protein fouling,...
Pineal region tumors are rare intracranial that more common in children than adults. Surgical management of this using a tailored approach is strategy enhances extent resection and neurological outcome.To review our institutional experience with pineal adults over the past 10 years.Our pathology database patient records were retrospectively reviewed for details regarding clinical radiological presentation, surgical management, resection, morbidity, outcome. Statistical analysis was performed...
Post-traumatic hydrocephalus (PTH) is a potentially treatable cause of poor recovery from traumatic brain injury (TBI) that remains poorly understood, particularly among children.To better understand the risk factors for pediatric PTH using large, multi-institutional database.We conducted retrospective cohort study administrative data 42 hospitals participating in Pediatric Health Information System. All patients ≤21 yr surviving hospitalization with an International Classification Diseases,...
Shunt obstruction in the treatment of hydrocephalus is poorly understood, multi-factorial, and many cases modeled ineffectively. Several mechanisms may be responsible, one which involves shunt infiltration by reactive cells from brain parenchyma. This has not been culture cannot consistently examined vivo without a large sample size. We have developed tested three-dimensional vitro model astrocyte migration proliferation around clinical grade ventricular catheters into catheter holes that...
In the endovascular treatment of wide-necked unruptured aneurysms, there is controversy over which adjunctive device (stent vs balloon) appropriate. At payer level it has been posited that stents and balloons treat same and, as such, more expensive should not be reimbursed.We challenge this assertion, instead hypothesize aneurysms treated with stent assistance are morphologically different than those selected for balloon assistance.Retrospective review an between 2008 2010. Morphological...
Hemangiopericytomas (HPCs) are rare dural-based neoplasms. Preoperative embolization of these notoriously hypervascular tumors can be challenging as they often receive their dominant blood supply from pial feeders arising the internal carotid artery (ICA) or vertebrobasilar (VB) circulation. This study reviews our historical experience with HPC and introduces transtumoral technique for backfilling tumor vasculature by delivering Onyx-18 through diminutive external (ECA) feeders.A...
Herniated intervertebral discs can result in pain and neurological compromise. Treatment for this condition is categorized as surgical or non-surgical. We sought to identify trends inpatient management of herniated using a national database.Patient discharges identified with principal procedure relating laminectomy excision disc were selected from the Nationwide Inpatient Sample (Healthcare Cost Utilization Project - Agency Healthcare Research Quality, Rockville, MD), under auspices data...
Study Design. Retrospective study. Objective. To define distinct Klippel-Feil syndrome (KFS) patient phenotypes that are associated with the need for surgical intervention. Summary of Background Data. KFS is characterized by congenital fusion cervical vertebrae; however, patients often present a variety other spinal and extraspinal anomalies suggesting this encompasses heterogeneous population. Moreover, it remains unclear how abnormalities seen in correlate to neurological outcomes Methods....
Achondroplasia is the most common form of short-limb dwarfism in humans, with an incidence 1 25,000-40,000 live births. About one-third achondroplasia patients will require operative intervention for lumbar spinal stenosis, generally presenting progressive neurogenic claudication. The anatomy achondroplastic spine, shortened pedicles, hypertrophic zygapophyseal joints, and thickened laminae frequently results development multilevel interapophyseolaminar while stenosis usually absent at...