Randall M. Chesnut
A5070361361- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Arrest and Resuscitation
- Traumatic Brain Injury Research
- Trauma and Emergency Care Studies
- Cerebrospinal fluid and hydrocephalus
- Neurosurgical Procedures and Complications
- Spinal Fractures and Fixation Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Sepsis Diagnosis and Treatment
- S100 Proteins and Annexins
- Spine and Intervertebral Disc Pathology
- Hemodynamic Monitoring and Therapy
- Acute Ischemic Stroke Management
- Anesthesia and Neurotoxicity Research
- Intraoperative Neuromonitoring and Anesthetic Effects
- Intracranial Aneurysms: Treatment and Complications
- Neonatal Respiratory Health Research
- Optical Imaging and Spectroscopy Techniques
- Cervical and Thoracic Myelopathy
- Hip and Femur Fractures
- Autopsy Techniques and Outcomes
- Trauma Management and Diagnosis
- Head and Neck Surgical Oncology
- Facial Trauma and Fracture Management
- Cerebrovascular and Carotid Artery Diseases
University of Washington
2015-2024
Neurological Surgery
2015-2024
Harborview Medical Center
2015-2024
Harborview Injury Prevention and Research Center
2017-2023
Seattle University
1976-2022
Antwerp University Hospital
2022
University of Antwerp
2022
University of Cambridge
2022
Addenbrooke's Hospital
2022
Hospital Posadas
2020
The scope and purpose of this work is 2-fold: to synthesize the available evidence translate it into recommendations. This document provides recommendations only when there support them. As such, they do not constitute a complete protocol for clinical use. Our intention that these be used by others develop treatment protocols, which necessarily need incorporate consensus judgment in areas where current lacking or insufficient. We think important have evidence-based clarify what aspects...
As triage and resuscitation protocols evolve, it is critical to determine the major extracranial variables influencing outcome in setting of severe head injury. We prospectively studied from injury (GCS score ≤ 8) 717 cases Traumatic Coma Data Bank. investigated impact on hypotension (SBP < 90 mm Hg) hypoxia (Pao2 60 Hg or apnea cyanosis field) as secondary brain insults, occurring through resuscitation. Hypoxia were independently associated with significant increases morbidity mortality...
Induction of hypothermia in patients with brain injury was shown to improve outcomes small clinical studies, but the results were not definitive. To study this issue, we conducted a multicenter trial comparing effects those normothermia acute injury.
Intracranial-pressure monitoring is considered the standard of care for severe traumatic brain injury and used frequently, but efficacy treatment based on in improving outcome has not been rigorously assessed.
Abstract Indications for Surgery Timing Methods
Department of Medical Informatics and Clinical Epidemiology Oregon Health & Science University Portland, OR Neurological Surgery Safar Center for Resuscitation Research Pittsburgh School Medicine Pittsburgh, PA
Management algorithms for adult severe traumatic brain injury (sTBI) were omitted in later editions of the Brain Trauma Foundation's sTBI Guidelines, as they not evidence-based.We used a Delphi-method-based consensus approach to address management patients undergoing intracranial pressure (ICP) monitoring. Forty-two experienced, clinically active specialists from six continents comprised panel. Eight surveys iterated queries and comments. An in-person meeting included whole- small-group...
A relationship between reduced brain tissue oxygenation and poor outcome following severe traumatic injury has been reported in observational studies. We designed a Phase II trial to assess whether neurocritical care management protocol could improve levels patients with the feasibility of III efficacy study.
Abstract RECOMMENDATIONS (see Methodology) Indications for Surgery Timing Methods
Most traumatic brain injuries (TBIs) are classified as mild (mTBI) based on admission Glasgow Coma Scale (GCS) scores of 13 to 15. The prevalence persistent functional limitations for these patients is unclear.To characterize the natural history recovery daily function following mTBI vs peripheral orthopedic injury in first 12 months postinjury using data from Transforming Research and Clinical Knowledge Traumatic Brain Injury (TRACK-TBI) study, and, clinical computed tomographic (CT) scans,...
Abstract When the fourth edition of Brain Trauma Foundation's Guidelines for Management Severe Traumatic Injury were finalized in late 2016, it was known that results RESCUEicp (Trial Decompressive Craniectomy Intracranial Hypertension) randomized controlled trial decompressive craniectomy would be public after guidelines released. The guideline authors decided to proceed with publication but update recommendations later spirit “living guidelines,” whereby topics are updated more frequently,...
Current guidelines for the treatment of adult severe traumatic brain injury (sTBI) consist high-quality evidence reports, but they are no longer accompanied by management protocols, as these require expert opinion to bridge gap between published and patient care. We aimed establish a modern sTBI protocol patients with both intracranial pressure (ICP) oxygen monitors in place. Our consensus working group consisted 42 experienced actively practicing leaders from six continents. Having...
<h3>Importance</h3> Traumatic brain injury (TBI) has been associated with adverse mental health outcomes, such as posttraumatic stress disorder (PTSD) and major depressive (MDD), but little is known about factors that modify risk for these psychiatric sequelae, particularly in the civilian sector. <h3>Objective</h3> To ascertain prevalence of PTSD MDD among patients evaluated emergency department mild TBI (mTBI). <h3>Design, Setting, Participants</h3> Prospective longitudinal cohort study...
<h3>Importance</h3> Moderate to severe traumatic brain injury (msTBI) is a major cause of death and disability in the US worldwide. Few studies have enabled prospective, longitudinal outcome data collection from acute chronic phases recovery after msTBI. <h3>Objective</h3> To prospectively assess outcomes areas life function at 2 weeks 3, 6, 12 months <h3>Design, Setting, Participants</h3> This cohort study, as part Transforming Research Clinical Knowledge TBI (TRACK-TBI) was conducted 18...