A5027004066- Cardiac, Anesthesia and Surgical Outcomes
- Respiratory Support and Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Anesthesia and Sedative Agents
- Intensive Care Unit Cognitive Disorders
- Sepsis Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Intracranial Aneurysms: Treatment and Complications
- Anesthesia and Pain Management
- Hemodynamic Monitoring and Therapy
- Nosocomial Infections in ICU
- Anesthesia and Neurotoxicity Research
- Airway Management and Intubation Techniques
- Neurosurgical Procedures and Complications
- Intraoperative Neuromonitoring and Anesthetic Effects
- Cystic Fibrosis Research Advances
- Neonatal Respiratory Health Research
- Cerebrospinal fluid and hydrocephalus
- Family and Patient Care in Intensive Care Units
- Renal function and acid-base balance
- Blood transfusion and management
- Tracheal and airway disorders
- Emergency and Acute Care Studies
- COVID-19 Clinical Research Studies
- Palliative Care and End-of-Life Issues
Duke University
2021-2025
Duke University Hospital
2023-2025
Duke Medical Center
2023-2025
Yale University
2020-2024
Yale New Haven Hospital
2023
University of California, San Francisco
2023
Oregon Health & Science University
2014-2021
Cleveland Clinic
2021
Outcomes Research Consortium
2021
Committee on Publication Ethics
2021
Abstract Background Case-fatality from COVID-19 has been reported to be relatively high in patients age 65 years or older. We sought determine the age-specific rates of mortality at population level. Methods obtained information regarding total number deaths for six consecutive weeks beginning 50th recorded death, among 16 countries that a cases as April 12, 2020. performed an ecological study model per week by group (54 younger, 55–64 years, and older) sex using Poisson mixed effects...
: To investigate if light sedation favorably affects subsequent patient mental health compared with deep sedation. Symptoms of posttraumatic stress disorder are common in patients after they have undergone prolonged mechanical ventilation and associated depth.: Randomized, open-label, controlled trial.: Single tertiary care center.: Adult requiring ventilation.: Patients were randomized to receive either (patient awake cooperative) or asleep, awakening upon physical stimulation).:...
Bloodstream infections (BSIs) are a major public health problem associated with high morbidity. Little evidence exists regarding the epidemiology of BSIs and use appropriate empirical antimicrobial therapy.To estimate association between receipt initial therapy in-hospital mortality.This retrospective cross-sectional study used data from Premier Healthcare database 2016 to 2020. The analysis included 32 100 adult patients (aged ≥18 years) 183 US hospitals who received at least 1 new systemic...
<h3>Objective</h3> To investigate the efficacy and safety of 4 antipseudomonal treatments in children with cystic fibrosis recently acquired<i>Pseudomonas aeruginosa</i>infection. <h3>Design</h3> Randomized controlled trial. <h3>Setting</h3> Multicenter trial United States. <h3>Participants</h3> Three hundred four aged 1 to 12 years within 6 months of<i>P aeruginosa</i>detection. <h3>Interventions</h3> Participants were randomized antibiotic regimens for 18 (six 12-week quarters) between...
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are known to be associated with increased mortality costs in trauma patients. We estimated the independent impact of these conditions on cost, beyond severity which they correlated.One-year prospective cohort.All patients admitted intensive care unit a level I center were evaluated daily for ALI/ARDS using American-European Consensus Conference definition.The main outcome measures hospital costs. Logistic regression was...
Intensive insulin therapy (IIT) with tight glycemic control may reduce mortality and morbidity in critically ill patients has been widely adopted practice throughout the world. However, there is only one randomized controlled trial showing unequivocal benefit to this approach that study population was dominated by post-cardiac surgery patients. We aimed determine association between IIT a mixed of patients.We conducted cohort comparing three consecutive time periods before after protocol...
Rationale: Introduction of sedation protocols has been associated with improved patient outcomes. It is not known if an update to existing high-quality protocol, featuring increased assessment and reduced benzodiazepine exposure, process outcome quality metrics.Methods: This was observational before (n = 703) after 780) cohort study mechanically ventilated patients in a 24-bed trauma-surgical intensive care unit (ICU) from 2009 2011. The three main protocol updates were: (1) requirement...
Prior studies supported an association between intensive care unit (ICU) organizational model or staffing patterns and outcome in critically ill patients.To examine the of closed versus open models with patient mortality across adult ICUs King County (WA).Cohort study patients acute lung injury (ALI).ICU structure, organization, practices were assessed using self-administered mail questionnaires completed by medical director nurse manager. We defined as units that required transfer to...
The authors sought to describe changes in clinical management associated with brain tissue oxygen (PbO(2)) monitoring and how these affected outcomes resource utilization.The cohort study comprised 629 patients admitted a Level I trauma center diagnosis of severe traumatic injury over period 3 years. Hospital mortality rate, neurological outcome, utilization 123 who underwent both PbO(2) intracranial pressure (ICP) were compared the same measures 506 ICP only. main hospital functional...
Residual paralysis is common after general anesthesia involving administration of neuromuscular blocking drugs (NMBDs). Management NMBDs and reversal frequently guided by train-of-four (TOF) monitoring. We hypothesized that monitoring eye muscles associated with more frequent residual than at the adductor pollicis.This prospective cohort study enrolled 180 patients scheduled for elective surgery anticipated use NMBDs. Collected variables included site, age, gender, weight, body mass index,...
Abstract Rationale The risk of pulmonary exacerbation following Pseudomonas aeruginosa ( Pa ) acquisition in children with cystic fibrosis (CF) is unknown. Objectives To determine if failure antibiotic therapy to eradicate and frequency recurrence are associated increased risk. Methods cohort included 282 CF who participated the EPIC trial ages 1–12 newly acquired , defined as either a first lifetime positive respiratory culture or after two years negative cultures (past isolation but >2...
Timing and preparation for tracheal extubation are as critical the initial intubation. There limited data on specific strategies a planned extubation. The extent to which difficult airway at reintubation contributes patient morbidity is unknown. aim of present study was describe occurrence complications failed associated risk factors, estimate mortality with attempts.Cohort 2,007 critically ill adult patients admitted ICU an ETT. Patients were classified in 2 groups, based requirement...
Poor sleep quality and short duration have been associated with elevated risk for several cancer types; however, the relationship between outcomes has not well characterized. We assessed association pre-diagnostic attributes subsequent survival within Women's Health Initiative (WHI).We identified WHI participants in whom a first primary invasive had diagnosed during follow-up (n = 21,230). Participants provided information on characteristics at enrollment. Cox regression was used to...