Abstract Background Case-fatality from COVID-19 has been reported to be relatively high in patients age 65 years or older. We sought determine the age-specific rates of mortality at population level. Methods obtained information regarding total number deaths for six consecutive weeks beginning 50th recorded death, among 16 countries that a cases as April 12, 2020. performed an ecological study model per week by group (54 younger, 55–64 years, and older) sex using Poisson mixed effects...

: To investigate if light sedation favorably affects subsequent patient mental health compared with deep sedation. Symptoms of posttraumatic stress disorder are common in patients after they have undergone prolonged mechanical ventilation and associated depth.: Randomized, open-label, controlled trial.: Single tertiary care center.: Adult requiring ventilation.: Patients were randomized to receive either (patient awake cooperative) or asleep, awakening upon physical stimulation).:...

Pectus excavatum repair using the Nuss procedure is associated with significant postoperative opioid consumption even in presence of a continuous thoracic paravertebral block. A CQI project was initiated by adding combined glucocorticoids as perineural adjuvants to An electronic health record review patients undergoing procedures single surgeon at major academic children's hospital from June 2013 December 2021 performed no excluded. The received pre-incision bilateral T4 blocks...

Intensive insulin therapy (IIT) with tight glycemic control may reduce mortality and morbidity in critically ill patients has been widely adopted practice throughout the world. However, there is only one randomized controlled trial showing unequivocal benefit to this approach that study population was dominated by post-cardiac surgery patients. We aimed determine association between IIT a mixed of patients.We conducted cohort comparing three consecutive time periods before after protocol...

Rationale: Introduction of sedation protocols has been associated with improved patient outcomes. It is not known if an update to existing high-quality protocol, featuring increased assessment and reduced benzodiazepine exposure, process outcome quality metrics.Methods: This was observational before (n = 703) after 780) cohort study mechanically ventilated patients in a 24-bed trauma-surgical intensive care unit (ICU) from 2009 2011. The three main protocol updates were: (1) requirement...

Renal function generally is assessed by measurement of GFR and urinary albumin excretion. Other intrinsic kidney functions, such as proximal tubular secretion, typically are not quantified. Tubular secretion solutes more efficient than glomerular filtration a major mechanism for renal drug elimination, suggesting important clinical consequences dysfunction. Measuring an independent marker may provide insight into disease etiology improve prediction adverse outcomes. We estimated measuring...

The American Society of Anesthesiologists' (ASA) Task Force on Management the Difficult Airway has developed a decision tree tool that uses inductive assessments to guide anesthesiologist's choice pathway in ASA's Algorithm. prompts anesthesiologist consider risk difficulty with laryngoscopy (direct or indirect) and tracheal intubation, facemask supraglottic ventilation, gastric contents aspiration, rapid oxyhemoglobin desaturation. For every airway management event, approach integrates...

Prior studies supported an association between intensive care unit (ICU) organizational model or staffing patterns and outcome in critically ill patients.To examine the of closed versus open models with patient mortality across adult ICUs King County (WA).Cohort study patients acute lung injury (ALI).ICU structure, organization, practices were assessed using self-administered mail questionnaires completed by medical director nurse manager. We defined as units that required transfer to...

The authors sought to describe changes in clinical management associated with brain tissue oxygen (PbO(2)) monitoring and how these affected outcomes resource utilization.The cohort study comprised 629 patients admitted a Level I trauma center diagnosis of severe traumatic injury over period 3 years. Hospital mortality rate, neurological outcome, utilization 123 who underwent both PbO(2) intracranial pressure (ICP) were compared the same measures 506 ICP only. main hospital functional...

The Lystedt law requires high school athletes who have sustained a concussion to be removed from practice and play not allowed return until cleared by medical professional.To determine the effect of on injury documentation in Seattle public schools.Cross-sectional study.Seattle schools.The numbers students, aged 13 19 years 2008-2009, 2009-2010, 2010-2011 years, were 4348, 4925, 4806, respectively.All injuries documented SportsWare athletic trainers schools. We evaluated all injuries,...

Timing and preparation for tracheal extubation are as critical the initial intubation. There limited data on specific strategies a planned extubation. The extent to which difficult airway at reintubation contributes patient morbidity is unknown. aim of present study was describe occurrence complications failed associated risk factors, estimate mortality with attempts.Cohort 2,007 critically ill adult patients admitted ICU an ETT. Patients were classified in 2 groups, based requirement...

Associations of C-reactive protein (CRP) and fibrinogen with death may weaken over time. Combining both markers improve prediction in older adults. In 5,828 Cardiovascular Health Study participants (United States, 1989-2000), 383 deaths (183 cardiovascular disease (CVD)) years 1-3 (early) 914 (396 CVD) 4-8 (late) occurred. For men, when comparing highest to lowest quartiles, hazard ratios for early were 4.1 (95% confidence interval (CI): 2.7, 6.3) CRP CI: 6.4) models adjusted CVD risk....

<h3>BACKGROUND:</h3> Assessment of a patient9s readiness for removal the endotracheal tube in ICU is based on respiratory, airway, and neurological measures. However, nearly 20% patients require reintubation. We created prediction model need reintubation, which incorporates variables importantly contributing to extubation failure. <h3>METHODS:</h3> This was cohort study 2,007 endotracheally intubated subjects who required admission at tertiary care center. Data collection included...

Common carotid artery intima-media thickness (IMT), a measure of subclinical cardiovascular disease, changes during the cardiac cycle. The magnitude this effect and its implications have not been well studied.Far-wall IMT measurements right common were measured at end diastole peak systole in 5633 individuals from Multi-Ethnic Study Atherosclerosis (MESA). Multivariable regression models generated with end-diastolic IMT, peak-systolic change cycle as dependent variables traditional risk...

Electromagnetic interference from monopolar electrosurgery may disrupt implantable cardioverter defibrillators.Current management recommendations by the American Society of Anesthesiologists and Heart Rhythm are based on expert clinical opinion since there is a paucity data regarding risk electromagnetic to defibrillators during surgery.With protocolized dispersive electrode positioning in patients with defibrillators, clinically meaningful was 7% above-the-umbilicus noncardiac surgery 0%...

The study was designed to investigate the association between sleep disturbances and common mental disorders (CMDs) among Peruvian college students. A total of 2538 undergraduate students completed a self-administered questionnaire gather information about characteristics, sociodemographic, lifestyle data. Evening chronotype, quality, daytime sleepiness were assessed using Horne Ostberg morningness–eveningness questionnaire, Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale,...

Abstract Editor’s Perspective What We Already Know about This Topic Article Tells Us That Is New Background Hispanic women choose epidural labor analgesia less commonly than non-Hispanic women. may represent a healthcare disparity related to language barrier and inadequate opportunities for education. It was hypothesized that language-concordant, educational program regarding epidurals would improve utilization in two independent cohorts of Methods A randomized controlled trial, blinded...

Biomedical studies often measure variables with error. Examples in the literature include investigation of association between change some outcome variable (blood pressure, cholesterol level etc.) and a set explanatory (age, smoking status etc.). Typically, one fits linear regression models to investigate such associations. With measured error, problem occurs when we baseline value as covariate. In instances, can find relationship observed even there is no these true variable. We present...

We sought to examine prospectively the association of serum homocysteine and methylene tetrahydrofolate reductase (MTHFR) C677T gene polymorphism with risk venous thromboembolism (VTE). studied these relationships in a nested case-control study 303 VTE cases 635 matched controls from population-based cohort 21,680 adults six U.S. communities. The highest quintile carried non-statistically significant adjusted odds ratio 1.55 (95% CI, 0.93-2.58) compared lowest overall but among aged 45-64...