A5008915794- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Cardiac Arrest and Resuscitation
- Neurological disorders and treatments
- Cerebrospinal fluid and hydrocephalus
- Advanced MRI Techniques and Applications
- Trauma and Emergency Care Studies
- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Spinal Fractures and Fixation Techniques
- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Nicotinic Acetylcholine Receptors Study
- Neuroscience and Music Perception
- Fetal and Pediatric Neurological Disorders
- Parkinson's Disease Mechanisms and Treatments
- Meningioma and schwannoma management
- Hemispheric Asymmetry in Neuroscience
- Hearing Loss and Rehabilitation
- Ultrasound and Hyperthermia Applications
- Spinal Cord Injury Research
- Spinal Dysraphism and Malformations
- Multisensory perception and integration
- Barrier Structure and Function Studies
- Neuroendocrine regulation and behavior
University of Maryland, Baltimore
2014-2025
University of Maryland, Baltimore County
2025
Wolfson Medical Center
2025
Tel Aviv University
2025
University of Maryland, College Park
1998-2025
University of Maryland Medical Center
2001-2024
Brigham and Women's Hospital
2019
Stanford University
2019
University of Virginia
1991-2019
University of Toronto
1979-2019
Studies in animals indicate that methylprednisolone and naloxone are both potentially beneficial acute spinal-cord injury, but whether any treatment is clinically effective remains uncertain.
As triage and resuscitation protocols evolve, it is critical to determine the major extracranial variables influencing outcome in setting of severe head injury. We prospectively studied from injury (GCS score ≤ 8) 717 cases Traumatic Coma Data Bank. investigated impact on hypotension (SBP < 90 mm Hg) hypoxia (Pao2 60 Hg or apnea cyanosis field) as secondary brain insults, occurring through resuscitation. Hypoxia were independently associated with significant increases morbidity mortality...
✓ A new classification of head injury based primarily on information gleaned from the initial computerized tomography (CT) scan is described. It utilizes status mesencephalic cisterns, degree midline shift in millimeters, and presence or absence one more surgical masses. The term “diffuse injury” divided into four subgroups, defined as follows: Diffuse Injury I includes all diffuse injuries where there no visible pathology; II which cisterns are present, less than 5 mm, and/or high-...
Uncontrolled pilot studies have suggested the efficacy of focused ultrasound thalamotomy with magnetic resonance imaging (MRI) guidance for treatment essential tremor.We enrolled patients moderate-to-severe tremor that had not responded to at least two trials medical therapy and randomly assigned them in a 3:1 ratio undergo unilateral or sham procedure. The Clinical Rating Scale Tremor Quality Life Essential Questionnaire were administered baseline 1, 3, 6, 12 months. assessments videotaped...
✓ This study describes the relationship between raised intracranial pressure (ICP), hypotension, and outcome from severe head injury. The is based on information derived Traumatic Coma Data Bank where ICP records a relatively large number of patients were available to help delineate major factors influencing outcome. From total data base 1030 patients, 428 met minimum monitoring duration criteria for inclusion in present analysis. Outcome was classified according Glasgow Scale score...
✓ The majority of hospital admissions for head trauma are due to minor injuries; that is, no or only transient loss consciousness without major complications and not requiring intracranial surgery. Despite the low mortality rate following injury, there is controversy surrounding extent morbidity long-term sequelae. authors postulated consecutively admitted patients who fulfilled research diagnostic criteria injury were carefully screened antecedent neuropsychiatric disorder prior would...
✓ The 1-year follow-up data of a multicenter randomized controlled trial methylprednisolone (30 mg/kg bolus and 5.4 mg/kg/hr for 23 hours) or naloxone (5.4 4.0 treatment acute spinal cord injury are reported compared with placebo results. In patients treated within 8 hours injury, increased recovery neurological function was seen at 6 weeks months continued to be observed 1 year after injury. For motor function, this difference statistically significant (p = 0.030), found in total sensory...
✓ In this prospective multicenter study, the authors have examined data derived from initial computerized tomography (CT) scans of 753 patients with severe head injury. When CT findings were related to abnormal intracranial pressure and death, most important characteristics were: midline shift; compression or obliteration mesencephalic cisterns; presence subarachnoid blood. Diffuse hemispheric swelling was also found be associated an early episode either hypoxia hypotension.
Object The aim of this study was to assess outcome following decompressive craniectomy for malignant brain swelling due closed traumatic injury (TBI). Methods During a 48-month period (March 2000–March 2004), 50 967 consecutive patients with TBI experienced diffuse and underwent craniectomy, without removal clots or contusion, control intracranial pressure (ICP) reverse dangerous shifts. Diffuse demonstrated in 44 patients, an evacuated mass lesion four whom had been performed as separate...
✓ The outcome of severe head injury was prospectively studied in patients enrolled the Traumatic Coma Data Bank (TCDB) during 45-month period from January 1, 1984, through September 30, 1987. were collected on 1030 consecutive admitted with (defined as a Glasgow Scale (GCS) score 8 or less following nonsurgical resuscitation). Of these, 284 either brain-dead admission had gunshot wound to brain. Patients these two groups excluded, leaving 746 available for this analysis. overall mortality...
A multicenter double-blind randomized trial was conducted to examine the efficacy of a high dose methylprednisolone (1,000-mg bolus and daily thereafter for ten days) compared with standard (100-mg in 330 patients acute spinal cord injury. No difference neurological recovery motor function or pinprick light touch sensation observed between two treatment groups six weeks months after The lack effect independent severity initial lesion time from injury starting treatment. Although not...
To investigate the inter-rater reliability and validity of Neurobehavioural Rating Scale at various stages recovery after hospitalisation for closed head injury, we studied 101 trauma patients who had no antecedent neuropsychiatric disorder. The results demonstrated satisfactory showed that reflects both severity chronicity injury. A principal components analysis revealed four factors which were differentially related to injury presence a frontal lobe mass lesion. Although our findings...
✓ This paper describes the pilot phase of National Traumatic Coma Data Bank, a cooperative effort six clinical head-injury centers in United States. were collected on 581 hospitalized patients with severe non-penetrating traumatic head injury. Severe injury was defined basis Glasgow Scale (GCS) score 8 or less following nonsurgical resuscitation deterioration to GCS within 48 hours after A common data collection protocol, definitions, and instruments developed put into use by all commencing...
Mr. Chairman, ladies and gentlemen, it is an honor to receive from the American Society of Pharmacology Experimental Therapeutics 1996 Otto Krayer Award sponsored by Zeneca Pharmaceutics Co. I am especially delighted this award not only because remarkable contributions that
Levin, Harvey S.; Eisenberg, Howard M.; Benton, Arthur L.; Hickey, Rosemary MD Author Information
Twenty patients admitted for minor or moderate closed-head injury were studied to investigate the relationship between magnetic resonance imaging (MRI) and neurobehavioral sequelae. The MRI scans demonstrated 44 more intracranial lesions than did concurrent computerized tomography (CT) in 17 (85%); most of these located frontal temporal regions. Estimates lesion volume based on frequently greater with CT; however, disclosed no additional that required surgical evacuation. Neuropsychological...
✓ A multi-center double-blind randomized clinical trial was conducted by the National Acute Spinal Cord Injury Study Group to examine efficacy of high-dose methylprednisolone (1000-mg bolus and 1000 mg daily thereafter for 10 days) compared with that a standard dose (100-mg 100 days). No significant difference observed in neurological recovery motor function, pinprick response, or touch sensation 1 year after injury between two treatment groups, adjustment other potentially confounding...
Unilateral focused ultrasound ablation of the internal segment globus pallidus has reduced motor symptoms Parkinson's disease in open-label studies.We randomly assigned, a 3:1 ratio, patients with and dyskinesias or fluctuations impairment off-medication state to undergo either opposite most symptomatic side body sham procedure. The primary outcome was response at 3 months, defined as decrease least points from baseline score on Movement Disorders Society-Unified Disease Rating Scale, part...
✓ The investigators undertook a retrospective analysis of ventriculostomy infections to evaluate their relationship monitoring duration and prophylactic catheter exchange. In 1984, the results an epidemiological study ventriculostomy-related infection were published. One conclusions paper was that incidence rose after 5 days monitoring. This led recommendation catheters be prophylactically changed at 5-day intervals if prolonged required. A recent randomized prospective on central venous...
Neuronal nicotinic receptors (nAChR) are known to control transmitter release in the CNS. Thus, this study was aimed at exploring diversity and localization of nAChRs present CA1 interneurons rat hippocampal slices. The use a U-tube as agonist delivery system critical for reliable detection responses induced by brief exposure neurons ACh or alpha7 nAChR-selective choline. demonstrated that interneurons, addition expressing functional nAChRs, also express alpha4beta2-like activation both...
✓ The outcome 1 year after they had sustained a severe head injury was investigated in patients who were admitted to the neurosurgery service at one of four centers participating Traumatic Coma Data Bank (TCDB). Of 300 eligible survivors, quality recovery assessed by least Glasgow Outcome Scale (GOS) 263 (87%), whereas complete neuropsychological assessment performed 127 (42%) survivors. capacity undergo testing criterion as reflected significant relationship neurological indices acute and...
✓ To better understand the relationship between patient age and clinical outcome following traumatic coma, data for 661 patients, aged 15 years or older at time of receiving a nonpenetrating head injury, were analyzed. All patients prospectively followed information was entered into Traumatic Coma Data Bank. This statistically analyzed to determine trends interactions other prognostic indicators. Older had higher rates mortality overall; vegetative survival seen in 4.8% 8.0% did not exhibit...