A5103005988- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Ultrasound and Hyperthermia Applications
- Parkinson's Disease and Spinal Disorders
- Genetic Neurodegenerative Diseases
- Transcranial Magnetic Stimulation Studies
- Long-Term Effects of COVID-19
- Glycogen Storage Diseases and Myoclonus
- Obsessive-Compulsive Spectrum Disorders
- Spine and Intervertebral Disc Pathology
- Neuroscience and Neural Engineering
- Salivary Gland Tumors Diagnosis and Treatment
- Diabetic Foot Ulcer Assessment and Management
- Neurological and metabolic disorders
- Intraoperative Neuromonitoring and Anesthetic Effects
- Nerve injury and regeneration
- Pancreatitis Pathology and Treatment
- Stroke Rehabilitation and Recovery
- Cerebrospinal fluid and hydrocephalus
- Peripheral Neuropathies and Disorders
- Ear and Head Tumors
- Ultrasound Imaging and Elastography
University Hospital HM Puerta del Sur
2017-2025
HM Hospitales
2021-2025
Hospital Universitario Ramón y Cajal
2013-2024
Universidad Autónoma de Madrid
2024
Universidad San Pablo CEU
2017-2021
Biomedical Research Networking Center on Neurodegenerative Diseases
2019-2021
University of Chile
1995
Abstract MR-guided focused ultrasound (MRgFUS), in combination with intravenous microbubble administration, has been applied for focal temporary BBB opening patients neurodegenerative disorders and brain tumors. MRgFUS could become a therapeutic tool drug delivery of putative neurorestorative therapies. Treatment Parkinson’s disease dementia (PDD) is an important unmet need. We initiated prospective, single-arm, non-randomized, proof-of-concept, safety feasibility phase I clinical trial...
The subthalamic nucleus is the preferred neurosurgical target for deep-brain stimulation to treat cardinal motor features of Parkinson's disease. Focused ultrasound an imaging-guided method creating therapeutic lesions in structures, including nucleus.We randomly assigned, a 2:1 ratio, patients with markedly asymmetric disease who had signs not fully controlled by medication or were ineligible surgery undergo focused subthalamotomy on side opposite their main sham procedure. primary efficacy...
Unilateral focused ultrasound ablation of the internal segment globus pallidus has reduced motor symptoms Parkinson's disease in open-label studies.We randomly assigned, a 3:1 ratio, patients with and dyskinesias or fluctuations impairment off-medication state to undergo either opposite most symptomatic side body sham procedure. The primary outcome was response at 3 months, defined as decrease least points from baseline score on Movement Disorders Society-Unified Disease Rating Scale, part...
Intracerebral vector delivery in nonhuman primates has been a major challenge. We report successful blood-brain barrier opening and focal of adeno-associated virus serotype 9 vectors into brain regions involved Parkinson’s disease using low-intensity focus ultrasound adult macaque monkeys. Openings were well tolerated with generally no associated abnormal magnetic resonance imaging signals. Neuronal green fluorescent protein expression was observed specifically confirmed opening. Similar...
Abstract Background Parkinson's disease (PD) exhibits a high prevalence of dementia as severity and duration progress. Focused ultrasound (FUS) has been applied for transient blood–brain barrier (BBB) opening cortical regions in neurodegenerative disorders. The striatum is primary target delivery putative therapeutic agents PD. Objective Here, we report prospective, single‐arm, nonrandomized, proof‐of‐concept, phase I clinical trial (NCT03608553 amended) PD with to test the safety...
Background Unilateral magnetic resonance-guided focused ultrasound (FUS) thalamotomy is efficacious for the treatment of medically refractory essential tremor (ET). Viability bilateral FUS ablation unexplored. Methods Patients diagnosed with ET and previously treated unilateral at least 5 months before underwent treatment. The timepoints were baseline (before first thalamotomy) FUS1 FUS2 (4 weeks 6 after second thalamotomy, respectively). primary endpoint was safety. Efficacy assessed...
Unilateral magnetic resonance imaging (MRI)-guided focused ultrasound subthalamotomy (FUS-STN) improves cardinal motor features among patients with asymmetrical Parkinson disease (PD). The feasibility of bilateral FUS-STN is as yet unexplored.
ABSTRACT Background The subthalamic nucleus (STN) is considered a key structure in motor, behavioral, and emotional control. Although identification of the functional topography STN has therapeutic implications treatment motor features Parkinson's disease (PD), details its somatotopic organization humans are not well understood. Objective aim this study was to characterize correlation with outcomes induced by subthalamotomy. Methods We used diffusion‐weighted imaging assess connectivity...
Abstract Background Unilateral focused ultrasound ventral intermediate thalamotomy (Vim‐FUS) is effective in treating Parkinson's disease (PD) tremor. Ultrasound ablation of the subthalamic nucleus (STN‐FUS) has demonstrated efficacy improving all cardinal motor features PD, including Objective To compare parkinsonian tremor control between Vim‐FUS and STN‐FUS. Methods Retrospective, two‐center study consecutive PD patients with medication‐refractory who underwent unilateral or STN‐FUS June...
The nigrostriatal system is especially vulnerable to neurodegeneration in Parkinson's disease (PD) and the blood-brain barrier (BBB) a limiting factor for delivery of therapeutic agents brain. This pilot study aimed demonstrate safety, feasibility tissue penetration (by 18F-Choline-positron emission tomography (PET)) MR-guided focused ultrasound (MRgFUS) simultaneous BBB opening (BBB-O) substantia nigra (SN) putamen PD.
Background Unilateral focused ultrasound subthalamotomy (FUS-STN) improves motor features of Parkinson’s disease (PD) in moderately advanced patients. The less invasive nature FUS makes its early application PD feasible. We aim to assess the safety and efficacy unilateral FUS-STN patients with than 5 years from diagnosis (early PD). Methods Prospective, open-label study. Eligible had highly asymmetrical cardinal features. primary outcome was safety, defined as treatment-related adverse...
Subthalamotomy using transcranial magnetic resonance-guided focused ultrasound (tcMRgFUS) is a novel and promising treatment for Parkinson's Disease (PD). In this study, we investigate if baseline brain imaging features can be early predictors of tcMRgFUS-subthalamotomy efficacy, as well which are the post-treatment changes associated with clinical outcomes. Towards aim, functional structural neuroimaging extensive data from thirty-five PD patients enrolled in double-blind trial were...
Multiple sclerosis (MS)-related tremor is frequent and can often be refractory to medical treatment, which makes it a potential source of major disability. Functional neurosurgery approaches such as thalamic deep brain stimulation (DBS) or radiofrequency thalamotomy are proven effective, but the application invasive techniques in MS has so far been limited. Magnetic resonance (MR)-guided focused ultrasound thalamotomy, already approved for treating essential parkinsonian tremor, provides...
Essential tremor (ET) is the most common movement disorder, affecting 1% of population worldwide. There sound evidence that medically refractory improves with thalamotomy and deep brain stimulation (DBS) targeting thalamic ventralis intermedius nucleus (VIM). In last few years, incisionless technique magnetic resonance-guided focused ultrasound (MRgFUS) has been demonstrated to be an effective procedure for unilateral thalamotomy,1 a positive profile regard side effects. The thalamus...
Deep brain stimulation of the subthalamic nucleus is efficient for treatment motor symptoms (i.e., tremors) in patients with Parkinson's disease. Gait disorders usually appear during advanced stages idiopathic disease up to 80% and have an important impact on their quality life. The effects deep gait balance are still controversial. For this reason, alternative targets been considered, such as pedunculopontine pars reticulata substantia nigra, involved integration functional connections...