A5080718356- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Advanced MRI Techniques and Applications
- Botulinum Toxin and Related Neurological Disorders
- Ultrasound and Hyperthermia Applications
- Transcranial Magnetic Stimulation Studies
- Neuroscience and Neural Engineering
- Alzheimer's disease research and treatments
- Parkinson's Disease and Spinal Disorders
- Glycogen Storage Diseases and Myoclonus
- Voice and Speech Disorders
- Ultrasound Imaging and Elastography
- Obsessive-Compulsive Spectrum Disorders
University Hospital HM Puerta del Sur
2017-2023
Biomedical Research Networking Center on Neurodegenerative Diseases
2020-2023
HM Hospitales
2021-2023
Universidad Europea
2019-2023
Centro de Investigación Biomédica en Red
2023
Instituto de Salud Carlos III
2023
Universidad San Pablo CEU
2017-2021
Universidad Europea
2019
Abstract MR-guided focused ultrasound (MRgFUS), in combination with intravenous microbubble administration, has been applied for focal temporary BBB opening patients neurodegenerative disorders and brain tumors. MRgFUS could become a therapeutic tool drug delivery of putative neurorestorative therapies. Treatment Parkinson’s disease dementia (PDD) is an important unmet need. We initiated prospective, single-arm, non-randomized, proof-of-concept, safety feasibility phase I clinical trial...
The subthalamic nucleus is the preferred neurosurgical target for deep-brain stimulation to treat cardinal motor features of Parkinson's disease. Focused ultrasound an imaging-guided method creating therapeutic lesions in structures, including nucleus.We randomly assigned, a 2:1 ratio, patients with markedly asymmetric disease who had signs not fully controlled by medication or were ineligible surgery undergo focused subthalamotomy on side opposite their main sham procedure. primary efficacy...
Abstract Background Parkinson's disease (PD) exhibits a high prevalence of dementia as severity and duration progress. Focused ultrasound (FUS) has been applied for transient blood–brain barrier (BBB) opening cortical regions in neurodegenerative disorders. The striatum is primary target delivery putative therapeutic agents PD. Objective Here, we report prospective, single‐arm, nonrandomized, proof‐of‐concept, phase I clinical trial (NCT03608553 amended) PD with to test the safety...
Unilateral magnetic resonance-guided focused ultrasound subthalamotomy (FUS-STN) has been shown to improve the cardinal motor features of Parkinson disease (PD). Whether this effect is sustained not known. This study aims report long-term outcome patients with PD treated unilateral FUS-STN.We conducted a prospective open-label asymmetrical who underwent FUS-STN. All were evaluated up 36 months after treatment. The primary was difference from baseline FUS-STN in score Movement Disorder...
In Parkinson's disease, striatal dopamine depletion produces profound alterations in the neural activity of cortico-basal ganglia motor loop, leading to dysfunctional output and parkinsonism. A key regulator is balance between excitation inhibition primary cortex, which can be assessed humans with transcranial magnetic stimulation techniques. Despite decades research, functional state cortical disease remains uncertain. Towards resolving this issue, we applied paired-pulse protocols 166...
Background Unilateral magnetic resonance-guided focused ultrasound (FUS) thalamotomy is efficacious for the treatment of medically refractory essential tremor (ET). Viability bilateral FUS ablation unexplored. Methods Patients diagnosed with ET and previously treated unilateral at least 5 months before underwent treatment. The timepoints were baseline (before first thalamotomy) FUS1 FUS2 (4 weeks 6 after second thalamotomy, respectively). primary endpoint was safety. Efficacy assessed...
Transcranial magnetic resonance-guided focused ultrasound (tcMRgFUS) thalamotomy is a novel and effective treatment for controlling tremor in essential patients.To provide comprehensive characterization of the radiological, topographical, volumetric aspects tcMRgFUS thalamic lesion, to quantify how they relate clinical outcomes.In this study, radiological data from forty patients with medically-refractory treated unilateral were retrospectively analyzed. Treatment efficacy was assessed...
Essential tremor (ET) is the most common movement disorder, affecting 1% of population worldwide. There sound evidence that medically refractory improves with thalamotomy and deep brain stimulation (DBS) targeting thalamic ventralis intermedius nucleus (VIM). In last few years, incisionless technique magnetic resonance-guided focused ultrasound (MRgFUS) has been demonstrated to be an effective procedure for unilateral thalamotomy,1 a positive profile regard side effects. The thalamus...
The microtubule-associated protein tau (MAPT) H1 homozygosity (H1/H1 haplotype) is a genetic risk factor for neurodegenerative diseases, such as Parkinson's disease (PD). MAPT has been associated with conversion to PD; however, results are conflicting since some studies did not find strong influence. Cortical hypometabolism cognitive impairment in PD. In this study, we aimed evaluate the metabolic pattern nondemented PD patients H1/H1 carriers comparison H1/H2 haplotype. addition, evaluated...