A5011962328- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Amyotrophic Lateral Sclerosis Research
- Dementia and Cognitive Impairment Research
- Neurogenetic and Muscular Disorders Research
- Alzheimer's disease research and treatments
- Restless Legs Syndrome Research
- Genetic Neurodegenerative Diseases
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Prion Diseases and Protein Misfolding
- Sleep and related disorders
- Sleep and Wakefulness Research
- Radiomics and Machine Learning in Medical Imaging
- Peripheral Neuropathies and Disorders
- Botulinum Toxin and Related Neurological Disorders
- RNA regulation and disease
- Neurological diseases and metabolism
- Acute Ischemic Stroke Management
- Neurobiology of Language and Bilingualism
- Adipose Tissue and Metabolism
- Epilepsy research and treatment
- Health disparities and outcomes
- Climate Change and Health Impacts
- Parkinson's Disease and Spinal Disorders
University of Bari Aldo Moro
2021-2025
King's College Hospital
2020-2025
King's College London
2019-2025
Harvard University
2024
University of Trieste
2024
John Wiley & Sons (United States)
2024
Hudson Institute
2024
King's College Hospital NHS Foundation Trust
2020-2023
University Hospital HM Puerta del Sur
2019-2022
Neuroscience Institute
2020
Diagnostic incidence data for syndromes associated with frontotemporal lobar degeneration (FTLD) in multinational studies are urgent light of upcoming therapeutic approaches.To assess the FTLD across Europe.The Frontotemporal Dementia Incidence European Research Study (FRONTIERS) was a retrospective cohort study conducted from June 1, 2018, to May 31, 2019, using population-based registry 13 tertiary research clinics UK, Netherlands, Finland, Sweden, Spain, Bulgaria, Serbia, Germany, and...
Anti-myelin oligodendrocyte glycoprotein antibodies (MOG-Ab) recently emerged as a potential biomarker in patients with inflammatory demyelinating diseases of the central nervous system. We here compare clinical and laboratory findings observed cohort MOG-Ab seropositive seronegative cases describe IgG subclass analysis results. Consecutive serum samples referred to Verona University Neuropathology Laboratory for aquaporin-4 (AQP4)-Ab and/or testing were analysed between March 2014 May 2017....
Abstract INTRODUCTION Sleep and rest–activity rhythm alterations are common in neurodegenerative diseases. However, their characterization patients with behavioral variant frontotemporal dementia (bvFTD) has proven elusive. We investigated alterations, sleep disturbances, neural correlates bvFTD. METHODS Twenty‐seven bvFTD 25 healthy controls completed questionnaires underwent 7 days of actigraphy while concurrently maintaining a diary. Cortical complexity thickness were calculated from...
The field of neurodegenerative diseases is a major challenge faced by public health and still in need robust preventive measures disease-modifying treatments. Population-based studies can offer the framework context primary secondary prevention diseases. epidemiology disorders last decades has focused on descriptive mainly based use clinical criteria. However, definition basically insufficient both to well-characterize different phenotypes make an early diagnosis. Descriptive needs new...
Objective Irisin, released by muscles during exercise, was recently identified as a neuroprotective factor in mouse models of Alzheimer disease (AD). In cohort AD patients, we studied cerebrospinal fluid (CSF) and plasma irisin levels, sex interactions, correlations with biomarkers. Methods Correlations between CSF levels biomarkers (amyloid β 1‐42, hyperphosphorylated tau, total tau [t‐tau]) Clinical Dementia Rating Scale Sum Boxes (CDR‐SOB) were analyzed patients dementia (n = 82), mild...
Human endogenous retroviruses (HERV) K/W seem to play a role in fostering and exacerbation of some neurological diseases, including amyotrophic lateral sclerosis (ALS). Given these findings, the immunity response against HERV-K HERV-W envelope surface (env-su) glycoprotein antigens serum cerebrospinal fluid (CSF) was investigated for ALS, multiple (MS) Alzheimer's disease patients healthy controls.Four antigenic peptides derived respectively from env-su proteins were studied 21 definite or...
To date, there are no clinically effective neuroprotective or disease-modifying treatments that can halt Parkinson's disease (PD) progression. The current clinical approach focuses on symptomatic management. This failure may relate to the complex neurobiology underpinning development of PD and absence true translational animal models. In addition, diagnosis relies presentation motor symptoms which occur when neuropathology is already established. These multiple factors could contribute...
Constipation is regarded as one of the prodromal features Parkinson's disease (PD) and there emerging evidence linking gastrointestinal dysfunction cognitive impairment (CI) in PD.We explored whether constipation associated with development CI two independent cohorts de novo PD patients (n = 196 from Non-motor International Longitudinal Study [NILS] n 423 Progression Markers Initiative [PPMI] study).Constipation was clinically defined using Non-Motor Symptoms Scale (NMSS) item-21 Scales for...
The increased incidence and the significant health burden associated with Parkinson's disease (PD) have stimulated substantial research efforts towards identification of effective treatments diagnostic procedures. Despite technological advancements, a cure is still not available PD often diagnosed long time after onset when irreversible damage has already occurred. Blood transcriptomics represents potentially disruptive technology for early diagnosis PD. We used transcriptome data from PPMI...
It has been recently suggested that LRRK2 mutations are associated with a more benign clinical phenotype and potentially preserved cholinergic function in Parkinson's disease (PD). However, to our knowledge, no studies have tested whether the better progression observed LRRK2-PD patients is volumes of brain area, basal forebrain (BF). To address this hypothesis, here we compared BF carriers without PD respect idiopathic (iPD) controls, assessed they iPD.Thirty-one symptomatic 13 asymptomatic...
The identification of biomarkers that reflect worse progression nonmotor symptoms (NMS) in Parkinson's disease (PD) is currently an unmet need. main aim this study was to investigate whether cerebrospinal fluid (CSF) and serum neurofilament light (NfL), measured at baseline or longitudinally, can be used predict the NMS patients with PD.Baseline longitudinal NfL levels were CSF 392 PD 184 healthy controls from Progression Marker Initiative. assessed using several scales, including, but not...
Background: Speech graph analysis (SGA) of dreams has recently shown promise as an objective and language-invariant diagnostic tool that can aid neuropsychiatric diagnosis. Whilst the notion dreaming mentations reflect distinct physiologic processes is not new, such studies in patients with sleep disorders remain exceptionally scarce. Here, using SGA other dream content analyses, we set to investigate structural thematic differences morning recalls diagnosed Non-Rapid Eye Movement Parasomnia...
Background The assessment of clinical prognosis in autoimmune encephalitis: Girona (ACPE-Gi) score is a scale for evaluating the severity acute phase encephalitis (AE) and predicting risk disability at 3 months, measured by modified Rankin (mRS). Methods Patients were strictly diagnosed with AE according to current criteria between 1 January 2009 31 March 2023 University Hospital Dr. Josep Trueta Girona, Catalonia, Spain. ACPE-Gi included 14 items, every item was scored from 0 3, depending...
Background: The frequent presentation of Alzheimer's disease (AD) with neuropsychiatric symptoms (NPS) in the context normal or minimally-impaired cognitive function led to concept Mild Behavioral Impairment (MBI). While MBI's impact on subsequent decline is recognized, its association brain network changes biologically-defined AD remains unexplored. Objective: To investigate correlation structural covariance networks MBI-C checklist sub-scores patients. Methods: We analyzed 33 patients,...
Network modeling is increasingly used to study brain alterations in neurological disorders. In this study, we apply a novel approach based on the similarity of regional radiomics feature characterize gray matter network changes patients with behavioral variant frontotemporal dementia (bvFTD) using MRI data. cross-sectional assessed structural 3 T data from twenty bvFTD and 20 cognitively normal controls. Radiomics features were extracted T1-weighted cortical subcortical segmentation....
Transcranial magnetic resonance-guided focused ultrasound (tcMRgFUS) thalamotomy is a novel and effective treatment for controlling tremor in essential patients.To provide comprehensive characterization of the radiological, topographical, volumetric aspects tcMRgFUS thalamic lesion, to quantify how they relate clinical outcomes.In this study, radiological data from forty patients with medically-refractory treated unilateral were retrospectively analyzed. Treatment efficacy was assessed...
Background: Sexual dysfunction (SD) is one of the least studied non-motor symptoms in Parkinson’s disease (PD). Objectives: To assess sexual function a cohort patients with early-onset PD (EOPD) and compare it to group healthy controls. Methods: In this cross-sectional multicenter study, SD was assessed gender-specific multi-dimensional self-reported questionnaires: The Brief Male Function Inventory (BSFI-M) Female Index (FSFI). Scores between controls were compared associations...
Radiomics is a challenging development area in imaging field that greatly capturing interest of radiologists and neuroscientists. However, radiomics features show strong non-biological variability determined by different facilities protocols, limiting the reproducibility generalizability analysis frameworks. Our study aimed to investigate usefulness harmonization reduce site-effects on over specific brain regions. We selected T1-weighted magnetic resonance (MRI) using MRI dataset Parkinson’s...