A5032631400- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Restless Legs Syndrome Research
- Botulinum Toxin and Related Neurological Disorders
- Long-Term Effects of COVID-19
- Genetic Neurodegenerative Diseases
- Sleep and Wakefulness Research
- Autism Spectrum Disorder Research
- Dysphagia Assessment and Management
- Neuroinflammation and Neurodegeneration Mechanisms
- Transcranial Magnetic Stimulation Studies
- Sleep and related disorders
- Balance, Gait, and Falls Prevention
- Parkinson's Disease and Spinal Disorders
- Conducting polymers and applications
- Child Nutrition and Feeding Issues
- Gut microbiota and health
- Neuroscience and Neuropharmacology Research
- Sympathectomy and Hyperhidrosis Treatments
- Gastrointestinal motility and disorders
- Probiotics and Fermented Foods
- COVID-19 and Mental Health
- Hallucinations in medical conditions
- Heart Rate Variability and Autonomic Control
- Biochemical Analysis and Sensing Techniques
King's College London
2019-2025
King's College Hospital
2019-2025
Fondazione IRCCS Istituto Neurologico Carlo Besta
2023-2025
King's College Hospital NHS Foundation Trust
2019-2024
National Institute for Health Research
2023
South London and Maudsley NHS Foundation Trust
2021
Bangur Institute of Neurosciences
2021
Institute of Neurosciences Kolkata
2021
Institute of Post Graduate Medical Education and Research
2021
Neuroscience Institute
2020
<h3>Objective:</h3> To investigate (1) whether phosphorylated α-synuclein deposits in skin nerve fibers might represent a useful biomarker for idiopathic Parkinson disease (IPD), and (2) the underlying pathogenesis of peripheral neuropathy associated with IPD. <h3>Methods:</h3> Twenty-one well-characterized patients IPD were studied together 20 parkinsonisms assumed not to have (PAR; 10 fulfilling clinical criteria vascular parkinsonism, 6 tauopathies, 4 parkin mutations) 30 controls....
Abstract Sialorrhoea in Parkinson’s disease (PD) is an often neglected yet key non-motor symptom with impact on patient quality of life. However, previous studies have shown a broad range prevalence figures. To assess drooling PD and its relationship to life, we performed retrospective analysis 728 consecutive patients who had baseline follow-up assessment as part the Non-motor International Longitudinal Study (NILS), for whom presence severity were available, assessed through Non-Motor...
We report here the potential role of a 4-strain probiotic suspension for use with patients Parkinson's disease (PD). Stool samples from group three diagnosed PD were used to create microbiotas in an
Abstract Growing evidence suggests that non-motor symptoms (NMS) in Parkinson’s disease (PD) have differential progression patterns a different natural history from motor and may be geographically influenced. We conducted cross-sectional analysis of 1607 PD patients whom 1327 were Europe, 208 the Americas, 72 Asia. The primary objective was to assess baseline burden, defined by Non-Motor Symptoms Scale (NMSS) total scores. Other aims included identifying factors predicting quality life,...
Device-aided therapies, including levodopa-carbidopa intestinal gel infusion, apomorphine subcutaneous and deep brain stimulation, are available in many countries for the management of advanced stage Parkinson’s disease (PD). Currently, selection device-aided therapies is mainly focused on patients’ motor profile while non-motor symptoms play a role limited to being regarded as possible exclusion criteria decision-making process delivery sustenance successful treatment. Differential...
Abstract To identify predictors of 36-month follow-up quality life (QoL) outcome after bilateral subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson’s disease (PD). In this ongoing, prospective, multicenter international study (Cologne, Manchester, London) including 73 patients undergoing STN-DBS, we assessed the following scales preoperatively and at 6-month follow-up: PD Questionnaire-8 (PDQ-8), NMSScale (NMSS), Scales for Outcomes (SCOPA)-motor examination, -activities daily...
Abstract Background Magnetic resonance–guided focused ultrasound (MRgFUS) thalamotomy of ventral intermediate (Vim) nucleus is useful to treat drug‐resistant tremor‐dominant Parkinson's disease (TdPD), but tremor relapse may occur. Predictors have been poorly investigated so far. Objective The aim this study evaluate the role clinico‐demographic, procedural, and neuroradiological variables in determining clinical response, relapse, adverse events (AEs) TdPD after MRgFUS Vim‐thalamotomy....
Conflicting data have been reported on resting autonomic tone in narcolepsy with cataplexy (NC), including reduced or increased sympathetic activity; to settle this important point, we aimed measure the and cardiovascular activities patients NC by direct microneurographic monitoring of muscle nerve activity (MSNA) during wakefulness.We studied 19 untreated established criteria for hypocretin deficiency sex- age-matched healthy subjects. Subjects underwent recording MSNA from peroneal heart...
Constipation is regarded as one of the prodromal features Parkinson's disease (PD) and there emerging evidence linking gastrointestinal dysfunction cognitive impairment (CI) in PD.We explored whether constipation associated with development CI two independent cohorts de novo PD patients (n = 196 from Non-motor International Longitudinal Study [NILS] n 423 Progression Markers Initiative [PPMI] study).Constipation was clinically defined using Non-Motor Symptoms Scale (NMSS) item-21 Scales for...