A5064986315- Sleep and Wakefulness Research
- Sleep and related disorders
- Restless Legs Syndrome Research
- EEG and Brain-Computer Interfaces
- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Circadian rhythm and melatonin
- Parkinson's Disease Mechanisms and Treatments
- Heart Rate Variability and Autonomic Control
- Epilepsy research and treatment
- Cardiovascular Syncope and Autonomic Disorders
- Neuroscience and Neuropharmacology Research
- Neurological and metabolic disorders
- Takotsubo Cardiomyopathy and Associated Phenomena
- Botulinum Toxin and Related Neurological Disorders
- Non-Invasive Vital Sign Monitoring
- Sleep and Work-Related Fatigue
- Action Observation and Synchronization
- Psychosomatic Disorders and Their Treatments
- Infant Health and Development
- Prion Diseases and Protein Misfolding
- Cognitive and developmental aspects of mathematical skills
- Homelessness and Social Issues
- Personality Disorders and Psychopathology
- Obsessive-Compulsive Spectrum Disorders
University of Bologna
2016-2025
Istituto delle Scienze Neurologiche di Bologna
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2015-2024
The Federal Polytechnic, Ado-Ekiti
2023
Federal Polytechnic, Mubi
2023
University of Verona
2020-2023
University of Parma
2020-2023
University of Bari Aldo Moro
2022
University of Modena and Reggio Emilia
2022
Inserm
2014-2019
Abstract Analysis of sleep for the diagnosis disorders such as Type-1 Narcolepsy (T1N) currently requires visual inspection polysomnography records by trained scoring technicians. Here, we used neural networks in approximately 3,000 normal and abnormal recordings to automate stage scoring, producing a hypnodensity graph—a probability distribution conveying more information than classical hypnograms. Accuracy was validated 70 subjects assessed six scorers. The best model performed better any...
Summary The aim of this study was to evaluate quantitatively the amplitude submentalis muscle EMG activity during sleep in controls and patients with idiopathic REM behavior disorder (RBD) or RBD multiple system atrophy (MSA). We recruited 21 RBD, 10 MSA, age‐matched 24 young normal controls. average rectified signal used for assessment atonia a Sleep Atonia Index developed; moreover, also chin activations were detected their duration interval analyzed. able distinguish clearly from NREM...
Our aim was to investigate the natural evolution of cataplexy and polysomnographic features in untreated children with narcolepsy cataplexy. To this end, clinical, polysomnographic, cataplexy-video assessments were performed at diagnosis (mean age 10 ± 3 disease duration 1 years) after a median follow-up years from symptom onset 12 4 21 hypocretin deficiency (tested 19 subjects). Video assessment also two control groups matched for sex first evaluation blindly scored presence hypotonic...
To describe the motor pattern of cataplexy and to determine its phenomenological differences from pseudocataplexy in differential diagnosis episodic falls. We selected 30 video-recorded 21 attacks 17 10 patients evaluated for suspected narcolepsy with final type 1 conversion disorder, respectively, together self-reported features, asked expert neurologists blindly evaluate features attacks. Video documented attack were contrasted. Video-recorded can be positively differentiated by occurrence...
To evaluate the reliability of nocturnal sleep dynamics in differential diagnosis central disorders hypersomnolence. Cross-sectional. Sleep laboratory. One hundred seventy-five patients with hypocretin-deficient narcolepsy type 1 (NT1, n = 79), 2 (NT2, 22), idiopathic hypersomnia (IH, and "subjective" hypersomnolence (sHS, 52). None. Polysomnographic (PSG) work-up included 48 h continuous PSG recording. From conventional macrostructure, occurrence onset rapid eye movement period (SOREMP),...
To examine repeatability of Multiple Sleep Latency Test (MSLT) results in narcolepsy type 1 (NT1) and 2 (NT2) according to the criteria International Classification Disorders, Third Edition (ICSD-3).Repeatability MSLT was retrospectively evaluated NT1 (n = 60) NT2 54) cases, controls 15). All subjects had documented HLA-DQB1*06:02 status and/or hypocretin-1 levels from cerebrospinal fluid. undergone MSLTs (≥ meeting ICSD-3 for narcolepsy). Repeatability explored children versus adults those...
To analyze periodic leg movements (PLM) during sleep in patients with narcolepsy and compare the results those obtained normal controls subjects restless legs syndrome (RLS).We recruited 40 HLA DQB1*0602-positive narcolepsy/cataplexy, 22 RLS, controls. The time structure of their polysomnographically recorded LMs was analyzed by means an approach particularly able to consider periodicity.Nineteen had a PLM index greater than 15. distribution inter-LM intervals clearly bimodal RLS...
Summary In the diagnostic work‐up of hypersomnias central origin, complaint excessive daytime sleepiness should be objectively confirmed by MSLT findings. Indeed, features and utility spontaneous sleep at 24 h continuous polysomnography (PSG) have never been investigated. We compared PSG to data in 98 consecutive patients presenting with a final diagnosis narcolepsy cataplexy/hypocretin deficiency ( n = 39), without cataplexy 7), idiopathic hypersomnia long time 19), ‘hypersomnia’ normal...
The brain suprapontine mechanisms associated with human cataplexy have not been clarified. Animal data suggest that the amygdala and ventromedial prefrontal cortex are key regions in promoting emotion-induced cataplectic attacks. Twenty-one drug-naive children/adolescent (13 males, mean age 11 years) recent onset of narcolepsy type 1 (NT1) were studied fMRI while viewing funny videos using a "naturalistic" paradigm. acquired synchronously EEG, mylohyoid muscle activity, video patient's face....
Type 1 narcolepsy is a central hypersomnia due to the loss of hypocretin-producing neurons and characterized by cataplexy, excessive daytime sleepiness, sleep paralysis, hypnagogic hallucinations disturbed nocturnal sleep. In children, close disease onset, type has peculiar clinical features with severe cataplexy complex admixture movement disorders occurring while awake. Motor dyscontrol during never been systematically investigated. Suspecting that abnormal motor control might affect also...
This study compared the features of isolated rapid eye movement (REM) sleep behavior disorder (iRBD) and antidepressant-related REM behaviour (RBD) with aim highlighting markers that might distinguish two entities.
To evaluate the amplitude of submentalis muscle EMG activity during sleep in patients with narcolepsy/cataplexy or without REM behavior disorder (RBD). Observational study consecutive recruitment. Sleep laboratory. Thirty-four and 35 age-matched normal controls. Half (17 subjects) had a clinical video polysomnographic diagnosis RBD. The average rectified signal was used to assess atonia, new Atonia Index computed. Chin activations were detected their duration interval analyzed. lower both...
Astute control of brain activity states is critical for adaptive behaviours and survival. In mammals birds, electroencephalographic recordings reveal alternating wakefulness, slow wave sleep paradoxical (or rapid eye movement sleep). This profoundly impaired in narcolepsy with cataplexy, a disease resulting from the loss orexin/hypocretin neurotransmitter signalling brain. Narcolepsy cataplexy characterized by irresistible bouts during day, fragmentation night episodes sudden muscle tone...
To validate polysomnographic markers (sleep latency and sleep-onset REM periods [SOREMPs] at the Multiple Sleep Latency Test [MSLT] nocturnal polysomnography [PSG]) for pediatric narcolepsy type 1 (NT1) against CSF hypocretin-1 (hcrt-1) deficiency presence of cataplexy, as no criteria are currently validated in children.Clinical, neurophysiologic, and, when available, biological data (HLA-DQB1*06:02 positivity, hcrt-1 levels) 357 consecutive children below 18 years age evaluated suspected...
Conflicting data have been reported on resting autonomic tone in narcolepsy with cataplexy (NC), including reduced or increased sympathetic activity; to settle this important point, we aimed measure the and cardiovascular activities patients NC by direct microneurographic monitoring of muscle nerve activity (MSNA) during wakefulness.We studied 19 untreated established criteria for hypocretin deficiency sex- age-matched healthy subjects. Subjects underwent recording MSNA from peroneal heart...
To search for discriminating biomarkers, 30 patients with idiopathic rapid-eye-movements sleep behavior disorder (iRBD) were compared 17 RBD within narcolepsy type 1. Both groups underwent extensive examinations, including skin biopsy searching phosphorylated α-synuclein deposits and whole-night video-polysomnography. Skin was positive in 86.7% of iRBD none narcoleptic patients. The analysis video-polysomnographic motor events showed differences their occurrence throughout the night two...
Narcolepsy type 1 (NT1) is characterized by hypersomnolence associated with early occurrence of REM sleep (i.e., sleep-onset periods [SOREMP]) and cataplexy sudden loss muscle tone evoked emotions), or CSF hypocretin-1 (CSF hcrt-1) low levels (below 110 pg/mL, undetectable in most cases). Compelling evidence indicates that NT1 caused an autoimmune disease affecting HLA-DQB1*06:02 carriers.1 Diagnostic workup requires a history multiple SOREMP at studies (nocturnal polysomnography latency...
Abstract Study Objectives Disrupted nighttime sleep (DNS) is a core narcolepsy symptom of unconsolidated resulting from hypocretin neuron loss. In this study, we define DNS objective measure and evaluate its diagnostic utility for pediatric type 1 (NT1). Methods This was retrospective, multisite, cross-sectional study polysomnograms (PSGs) in 316 patients, ages 6–18 years (n = 150 NT1, n 22 2, 27 idiopathic hypersomnia, 117 subjectively sleepy subjects). We assessed continuity PSG measures...
Abstract An increasing number of sleep applications are currently available and being widely used for in‐home tracking. The present study assessed four smartphone (Sleep Cycle‐Accelerometer, SCa ; Sleep Cycle‐Microphone, SCm Sense, Se Smart Alarm, SA ) designed sleep−wake detection through sound movement sensors, by comparing their performance with polysomnography. Twenty‐one healthy participants (six males, 15 females) the running on iPhone (provided experimenter) simultaneously portable...
The diagnosis of narcolepsy type 1 (NT1) currently requires the multiple sleep latency test (MSLT), or a nocturnal sleep-onset REM period (SOREMP) combined with typical cataplexy, alternatively determination CSF hypocretin-1 (CSF-hcrt-1) deficiency. We evaluated 24-hour polysomnography (PSG) recordings in adult and pediatric patients as an alternative diagnostic tool. Patients any age, referred to center university hospital for suspected central disorder hypersomnolence (CDH), were...
Abstract Narcolepsy type 1 (NT1) is a rare neurological disorder characterized by excessive daytime sleepiness and cataplexy, thought to result from an autoimmune process targeting the hypothalamic hypocretin-producing neurons. Aiming add clues latter hypothesis, we investigated circulating cell-free mitochondrial DNA (ccf-mtDNA) levels in cerebrospinal fluid (CSF), possible biomarker for neurodegeneration, neuroinflammation or immune activation, 46 NT1 patients with low CSF hypocretin-1,...