A5011290827- Heart Rate Variability and Autonomic Control
- Cardiovascular Syncope and Autonomic Disorders
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- EEG and Brain-Computer Interfaces
- Neuroscience of respiration and sleep
- Sleep and Wakefulness Research
- Functional Brain Connectivity Studies
- Migraine and Headache Studies
- Genetic Neurodegenerative Diseases
- Non-Invasive Vital Sign Monitoring
- Sleep and related disorders
- Transcranial Magnetic Stimulation Studies
- Circadian rhythm and melatonin
- Obstructive Sleep Apnea Research
- Infrared Thermography in Medicine
- Epilepsy research and treatment
- Thermoregulation and physiological responses
- Blood Pressure and Hypertension Studies
- Sleep and Work-Related Fatigue
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Botulinum Toxin and Related Neurological Disorders
- Pituitary Gland Disorders and Treatments
- Neurological diseases and metabolism
- Thermal Regulation in Medicine
University of Bologna
2016-2025
Istituto delle Scienze Neurologiche di Bologna
2011-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2016-2024
GTx (United States)
2024
Azienda Unita' Sanitaria Locale Di Modena
2016-2020
Ospedale Bellaria
2020
Institute of Neurological Sciences
1994-2018
Queen Elizabeth Hospital
2016
Lewisham and Greenwich NHS Trust
2016
Queen Elizabeth Hospital
2016
Narcolepsy with cataplexy (NC) is associated loss of hypocretin neurons in the lateral hypothalamus involved circadian timing sleep and wakefulness, many biologic functions including autonomic control. The authors investigated whether chronic lack signaling alters cardiovascular control during humans.Comparison 24-hr rhythms, day-night, time- state-dependent changes blood pressure (BP) heart rate (HR) drug-free patients NC subjects.University hospital.Ten (9 men, 1 woman) 12 subjects 3...
<h3>Objective:</h3> To evaluate the predictive value of stridor and its latency onset to investigate role treatment in a cohort patients with multiple system atrophy (MSA) referred tertiary center. <h3>Methods:</h3> We retrospectively identified diagnosed MSA our department beginning 1991 evaluated at least yearly during disease course. Stridor was defined as present when confirmed by whole night video-polysomnography early if presenting within 3 years onset. Survival data, from time death,...
To investigate (1) the prevalence of REM sleep behavior disorder (RBD) as mode disease onset in a cohort patients with multiple system atrophy (MSA) and (2) progression prognosis MSA RBD predating (pre-RBD) following (post-RBD) onset.We retrospectively identified all clinical diagnosis evaluated at least once year during course. Type was defined by first reported motor or autonomic symptom/sign related to MSA. The occurrence symptoms/signs milestone progression, their latency from onset,...
Levodopa (LD) is the main treatment for parkinsonism, but its use may be limited by a potential hypotensive effect.
Isolated REM sleep behavior disorder (iRBD) is a prodromal state of α-synucleinopathies, presenting years before overt neurodegenerative disorders. Autonomic nervous system (ANS) involvement, particularly cardiovascular autonomic failure, may indicate progression. However, its role as (multidimensional) marker for disease progression and phenoconversion remains unclear. This study aimed to investigate whether failure symptoms dysfunction serve multidimensional markers in patients with iRBD....
The objective of this study was to determine the cardiovascular effects chronic stimulation posterior hypothalamic area (PHA) in cluster headache (CH) patients. Systolic and diastolic blood pressure (SBP, DBP), cardiac output, total peripheral resistance (TPR), heart rate (HR) breathing were monitored at supine rest during head-up tilt test (HUTT), Valsalva manoeuvre, deep breathing, cold face isometric handgrip eight drug-resistant CH patients who underwent monolateral electrode...
<h3>Objective</h3> To retrospectively describe clinical and instrumental features of a cohort patients with at least 5-year history idiopathic autonomic failure (IAF) longitudinally evaluated the Autonomic Unit University Bologna (IAF-Bo cohort). <h3>Methods</h3> We identified IAF who were referred to our department from 1989 2016 once year during disease course. Clinical data collected medical records. variables categorized as early if presenting within 3 years onset. Predictors associated...
We investigated whether in human subjects, the pattern of coupling between spontaneous fluctuations heart period (HP) and those systolic blood pressure (SBP) differs among wake-sleep states. Polysomnographic recordings finger measurements were performed for 48 h 15 nonobese adults without sleep-disordered breathing. The cross-correlation function (CCF) HP SBP at frequencies <0.15 Hz was computed during quiet wakefulness (QW), light (stages 1 2) deep 3 4) nonrapid-eye-movement sleep (NREMS),...
Abstract OBJECTIVE: To evaluate whether the circadian rhythm of body core temperature (CRT°) can differentiate Multiple‐System Atrophy (MSA) from Idiopathic Parkinson's disease (IPD). METHODS: We evaluated 14 patients with probable MSA, seven IPD, and eight controls. After a preliminary evaluation cardiovascular autonomic function, rectal sleep‐wake cycle were monitored continuously for 48 hours in temperature‐controlled room, at constant bed rest controlled food intake fixed light‐dark...
The upright posture strengthens the coupling between heart period (HP) and systolic arterial pressure (SAP) consistently with a greater contribution of baroreflex to cardiac control, while paradoxically decreasing sensitivity (cBRS). To investigate physiological mechanisms that mediate HP SAP in response different postures, we analyzed cross-correlation functions low-frequency fluctuations estimated cBRS sequence technique healthy male subjects during passive head-up tilt test (HUTT, n =...
Hypocretin/orexin signalling varies among sleep-wake behaviours, impacts upon cardiovascular autonomic control and is impaired in patients with narcolepsy cataplexy (NC). However, evidence concerning disturbed NC contrasting, limited mainly to waking behaviour. We thus investigated whether of variability altered during wakefulness preceding sleep, light (1-2) deep (3-4) stages non-rapid eye movement (NREM) sleep rapid (REM) sleep. Polysomnographic recordings finger blood pressure...
Background: Increased prevalence of cardiovascular autonomic failure might play a key role on Parkinson’s disease (PD) progression glucocerebrosidase gene (GBA)-mutated patients, determining malignant phenotype in these patients. Objective: To objectively characterize, for the first time, profile GBA-mutated patients compared to idiopathic PD by means reflex tests (CRTs). Methods: This is case-control (1 : 2) study belonging well-characterized prospective cohorts. For each patient carrying...
Autonomic function in migraineurs during headache-free periods was studied by means of cardiovascular reflexes and power spectral analysis heart rate diastolic blood pressure variability. We examined 56 patients: 37 suffering from migraine without aura 19 with aura. Cardiovascular responses to the tilt test Valsalva manoeuvre showed a normal overall baroreceptor reflex arc. Normal valsalva deep breathing suggested an intact parasympathetic function. Power both variability basal conditions...