A5011726416- Sleep and Wakefulness Research
- Sleep and related disorders
- Neuroscience of respiration and sleep
- Circadian rhythm and melatonin
- Heart Rate Variability and Autonomic Control
- Regulation of Appetite and Obesity
- Restless Legs Syndrome Research
- Obstructive Sleep Apnea Research
- Parkinson's Disease Mechanisms and Treatments
- Non-Invasive Vital Sign Monitoring
- EEG and Brain-Computer Interfaces
- Adipose Tissue and Metabolism
- Genetics and Neurodevelopmental Disorders
- Diet and metabolism studies
- Cardiovascular and exercise physiology
- Sodium Intake and Health
- Neuroscience and Neuropharmacology Research
- Diverse academic and cultural studies
- Cannabis and Cannabinoid Research
- Neonatal and fetal brain pathology
- Dietary Effects on Health
- Epigenetics and DNA Methylation
- Sleep and Work-Related Fatigue
- Italy: Economic History and Contemporary Issues
- Advanced Chemical Sensor Technologies
University of Bologna
2016-2025
Proteogenomics Research Institute for Systems Medicine
2023
Institute of Neurological Sciences
2013
University of Chicago
2013
Mayo Clinic
2013
Mayo Clinic in Arizona
2013
The lack of noninvasive approaches to measure cardiac sympathetic nerve activity (CSNA) has driven the development indirect estimates such as low-frequency (LF) power heart rate variability (HRV). Recently, it been suggested that LF HRV can be used estimate baroreflex modulation period (HP) rather than tone. To test this hypothesis, we measured CSNA, HP, blood pressure (BP), and sensitivity (BRS) estimated with modified Oxford technique, in conscious sheep pacing-induced failure healthy...
We aimed to analyze quantitatively rapid eye movement (REM) sleep electroencephalogram (EEG) in controls, drug-naïve idiopathic REM behavior disorder patients (iRBD), and iRBD treated with clonazepam. Twenty-nine (mean age 68.2 years), 14 under chronic clonazepam therapy 66.3 21 controls 66.8 years) were recruited. Power spectra obtained from EEG (central derivation), using a 2-second sliding window, 1-second steps. The power values of each spectral band (one every second) normalized respect...
Although blood pressure during sleep and the difference in between wakefulness carry prognostic information, little is known on their central neural mechanisms. Hypothalamic neurons releasing hypocretin (orexin) peptides control wake-sleep behavior autonomic functions are lost narcolepsy-cataplexy. We investigated whether chronic lack of signaling alters sleep.Comparison as a function 2 different hypocretin-deficient mouse models mice with same genetic background.N/A.Hypocretin-ataxin3...
The central neural pathways underlying the physiological coordination between thermoregulation and controls of wake-sleep behavior cardiovascular function remain insufficiently understood. Growing evidence supports involvement hypocretin (orexin) peptides in behavioral, cardiovascular, thermoregulatory functions. We investigated whether effects ambient temperature on control depend hypothalamic neurons that release peptides. Orexin-ataxin3 transgenic mice with genetic ablation (n = 11)...
Abstract A major limitation in the study of sleep breathing disorders mouse models pathology is need to combine whole-body plethysmography (WBP) measure respiration with electroencephalography/electromyography (EEG/EMG) discriminate wake-sleep states. However, murine states may be discriminated from and body movements registered by WBP signal alone. Our goal was compare EEG/EMG-based WBP-based scoring mice, provide formal guidelines for latter. EEG, EMG, blood pressure signals were...
Sleep apnea is a common respiratory disorder in humans and consists of recurrent episodes cessation breathing or decrease airflow during sleep. can be classified as central obstructive, based on its origin. Central sleep results from an impaired transmission the signal for inspiration brain to inspiratory muscles, while obstructive occurs presence obstruction upper airways inspiration. This condition leads repetitive reduced oxygen elevated carbon dioxide levels bloodstream, which entail...
We investigated whether in human subjects, the pattern of coupling between spontaneous fluctuations heart period (HP) and those systolic blood pressure (SBP) differs among wake-sleep states. Polysomnographic recordings finger measurements were performed for 48 h 15 nonobese adults without sleep-disordered breathing. The cross-correlation function (CCF) HP SBP at frequencies <0.15 Hz was computed during quiet wakefulness (QW), light (stages 1 2) deep 3 4) nonrapid-eye-movement sleep (NREMS),...
A recently discovered neurodevelopmental disorder caused by the mutation of cyclin-dependent kinase-like 5 gene (CDKL5) entails complex autistic-like behaviours similar to Rett syndrome, but its impact upon physiological functions remains largely unexplored. Sleep-disordered breathing is common and potentially life-threatening in patients with syndrome; however, evidence limited children CDKL5 disorder, lacking altogether adults. The aim this study was test whether pattern during sleep...
Cannabinoid type 1 (CB1) receptors are highly expressed in the brain and play a role behavior control. Endogenous cannabinoid signaling is modulated by high-fat diet (HFD). We investigated consequences of congenital lack CB1 on sleep mice fed standard (SD) HFD. receptor knock-out (KO) wild-type (WT) were SD or HFD for 4 months (n = 9–10 per group). Mice instrumented with electroencephalographic (EEG) electromyographic electrodes. Recordings performed during baseline (48 hours), deprivation...