A5034559338- Sleep and Wakefulness Research
- Circadian rhythm and melatonin
- Neuroscience of respiration and sleep
- Sleep and related disorders
- Adipose Tissue and Metabolism
- Neuroscience and Neuropharmacology Research
- Regulation of Appetite and Obesity
- Heart Rate Variability and Autonomic Control
- Thermal Regulation in Medicine
- Mitochondrial Function and Pathology
- Genetic Syndromes and Imprinting
- Photoreceptor and optogenetics research
- Neural dynamics and brain function
- Diet and metabolism studies
- Genetic Neurodegenerative Diseases
- Obstructive Sleep Apnea Research
- Olfactory and Sensory Function Studies
- Neurological Disorders and Treatments
- Alzheimer's disease research and treatments
- Sleep and Work-Related Fatigue
- Cell Image Analysis Techniques
- Neurogenesis and neuroplasticity mechanisms
- Spaceflight effects on biology
- Bat Biology and Ecology Studies
- Spinal Dysraphism and Malformations
University of Bologna
2014-2024
Ospedale di San Donà di Piave
2021
GNA University
2020
Fondazione IRCCS Istituto Neurologico Carlo Besta
2015
Istituto di Fisiologia Clinica
1990
Summary The European Sleep Research Society aimed to estimate the prevalence, determinants and consequences of falling asleep at wheel. In total, 12 434 questionnaires were obtained from 19 countries using an anonymous online questionnaire that collected demographic sleep‐related data, driving behaviour, history drowsy accidents. Associations quantified multivariate logistic regression. average prevalence wheel in previous 2 years was 17%. Among respondents who fell asleep, median accidents...
The possibility of inducing a suspended animation state similar to natural torpor would be greatly beneficial in medical science, since it avoid the adverse consequence powerful autonomic activation evoked by external cooling. Previous attempts systemically inhibit metabolism were successful mice, but practically ineffective nonhibernators. Here we show that selective pharmacological inhibition key neurons central pathways for thermoregulatory cold defense is sufficient induce state,...
Abstract Counting cells in fluorescent microscopy is a tedious, time-consuming task that researchers have to accomplish assess the effects of different experimental conditions on biological structures interest. Although such objects are generally easy identify, process manually annotating sometimes subject fatigue errors and suffers from arbitrariness due operator’s interpretation borderline cases. We propose Deep Learning approach exploits fully-convolutional network binary segmentation...
Manual scoring of polysomnography data is labor-intensive and time-consuming, most existing software does not account for subjective differences user variability. Therefore, we evaluated a supervised machine learning algorithm, Somnivore™, automated wake-sleep stage classification. We designed an algorithm that extracts features from various input channels, following brief session manual scoring, provides classification each recording. For validation, was obtained independent laboratories,...
Abstract Torpor is a peculiar mammalian behaviour, characterized by the active reduction of metabolic rate, followed drop in body temperature. To enter torpor, activation all thermogenic organs that could potentially defend temperature must be prevented. Most these organs, such as brown adipose tissue, are controlled key thermoregulatory region Raphe Pallidus (RPa). Currently, it not known which brain areas mediate entrance into torpor. identify areas, expression early gene c-Fos at torpor...
Exposure to low ambient temperature (Ta) depresses REM sleep (REMS) occurrence. In this study, both short and long-term homeostatic aspects of REMS regulation were analyzed during cold exposure subsequent recovery at Ta 24°C. EEG activity, hypothalamic temperature, motor activity studied a 24-h Tas ranging from 10°C -10°C for 4 days recovery. Laboratory Physiological Regulation the Wake-Sleep Cycle, Department Human General Physiology, Alma Mater Studiorum-University Bologna. 24 male albino...
Thermoregulatory responses to temperature changes are not operant during REM sleep (REMS), but fully in non-REM and wakefulness. The specificity of the relationship between REMS impairment thermoregulation was tested by eliciting reflex release Thyrotropin Releasing Hormone (TRH), which is integrated at hypothalamic level. By inducing sequential secretion Thyroid Stimulating (TSH) Hormone, TRH intervenes regulation obligatory non-shivering thermogenesis. Experiments were performed on male...
Acute exposure to low ambient temperature modifies the wake-sleep cycle due stage-dependent changes in capacity regulate body temperature. This study was carried out make a systematic analysis of sleep parameters during different temperatures and following recoveries at 24 degrees C.Electroencephalographic activity, hypothalamic temperature, motor activity were studied 24-hour ranging from 10 C -10 for 4 days recovery.Laboratory Physiological Regulation Wake-Sleep Cycle, Department Human...
In recent years, sleep medicine has evolved into a full-grown discipline, featuring multidisciplinary approach to diagnosis and treatment of patients with disorders. Sleep cuts across the boundaries different conventional disciplines is therefore open medical non-medical professionals specialty backgrounds. The aim current paper introduce qualification for those whose main occupation practice in setting centre. drafting guidelines dealing requirements such was entrusted task force by...
Hibernation has been proposed as a tool for human space travel. In recent years, procedure to induce metabolic state known “synthetic torpor” in non-hibernating mammals was successfully developed. Synthetic torpor may not only be an efficient method spare resources and reduce psychological problems long-term exploratory-class missions, but also represent countermeasure against cosmic rays. Here we show the preliminary results from experiment rats exposed ionizing radiation normothermic...
Imprinted genes are highly expressed in the hypothalamus; however, whether specific imprinted affect hypothalamic neuromodulators and their functions is unknown. It has been suggested that Prader–Willi syndrome (PWS), a neurodevelopmental disorder caused by lack of paternal expression at chromosome 15q11–q13, characterized insufficiency. Here, we investigate role paternally Snord116 gene within context sleep metabolic abnormalities PWS, report significant this function organization 2 main...
SUMMARY The pattern of desynchronized sleep (DS) occurrence in the rat was studied during exposure to an ambient temperature (T a ) 0°C for 48 h and 12 recovery period at laboratory T (23°C) following first second 24 cold exposure. low induces DS deprivation which is followed, recovery, by clear rebound. Both decrease increase amount are due changes frequency rather than duration episodes. distribution intervals between end one episode beginning next (DS interval) has shown that two...
Neurons within the lateral hypothalamus (LH) are thought to be able evoke behavioural responses that coordinated with an adequate level of autonomic activity. Recently, acute pharmacological inhibition LH has been shown depress wakefulness and promote NREM sleep, while suppressing REM sleep. These effects have suggested consequence specific neuronal populations LH, i.e. orexin MCH neurons, respectively. However, interpretation these results is limited by lack quantitative analysis...
Tau protein is of primary importance for many physiological processes in neurons, where it affects the dynamics microtubule system. When hyperphosphorylated (PP-Tau), monomers detach from microtubules and tend to aggregate firstly oligomers, then neurofibrillary tangles, as occurs a group neurodegenerative disorders named thauopathies. A hypothermia-related accumulation PP-Tau, which quickly reversed after return normothermia, has been shown occur brain hibernators during torpor. Since,...
Fluorescent Neuronal Cells v2 is a collection of fluorescence microscopy images and the corresponding ground-truth annotations, designed to foster innovative research in domains Life Sciences Deep Learning. This dataset encompasses three image collections wherein rodent neuronal cell nuclei cytoplasm are stained with diverse markers highlight their anatomical or functional characteristics. Specifically, we release 1874 high-resolution alongside 750 annotations for several learning tasks,...
Abstract Thermoregulation is known to interfere with sleep, possibly due a functional interaction at the level of preoptic area (POA). Exposure low ambient temperature ( T ) induces sleep deprivation, which followed by rebound after return laboratory . As two POA subregions, ventrolateral nucleus (VLPO) and median (MnPO), have been proposed role in sleep‐related processes, expression c‐Fos phosphorylated form cAMP/Ca 2+ ‐responsive element‐binding protein (P‐CREB) was investigated these...
Wake-sleep (W-S) states are affected by thermoregulation. In particular, REM sleep (REMS) is reduced in homeotherms under a thermal load, due to an impairment of hypothalamic regulation body temperature. The aim this work was assess whether osmoregulation, which regulated at level, but, unlike thermoregulation, maintained across the different W-S states, could influence occurrence. Sprague-Dawley rats, kept ambient temperature 24°C and 12 h∶12 h light-dark cycle, were exposed prolonged...