A5065594704- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Tracheal and airway disorders
- Cardiovascular and Diving-Related Complications
- Respiratory Support and Mechanisms
- Sleep and Wakefulness Research
- Sleep and Work-Related Fatigue
- Sleep and related disorders
- Asthma and respiratory diseases
- Cardiovascular Disease and Adiposity
- Fatty Acid Research and Health
- Airway Management and Intubation Techniques
- Clinical practice guidelines implementation
- Non-Invasive Vital Sign Monitoring
- Delphi Technique in Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Restless Legs Syndrome Research
- Voice and Speech Disorders
- Regulation of Appetite and Obesity
- Dysphagia Assessment and Management
- Heart Rate Variability and Autonomic Control
- Gastroesophageal reflux and treatments
- Pleural and Pulmonary Diseases
- Inhalation and Respiratory Drug Delivery
University College Dublin
2016-2025
St. Vincent's University Hospital
2016-2025
Saint Vincent's Catholic Medical Center
1985-2022
First Affiliated Hospital of Guangzhou Medical University
2017-2020
Guangzhou Medical University
2017-2020
State Key Laboratory of Respiratory Disease
2018
University of Palermo
2010-2017
The First Affiliated Hospital, Sun Yat-sen University
2016
Fudan University
2016
Sun Yat-sen University
2016
The Standards for the Diagnosis and Treatment of Patients with COPD document 2004 updates position papers on chronic obstructive pulmonary disease (COPD) published by American Thoracic Society (ATS) European Respiratory (ERS) in 1995 1, 2. Both societies felt need to update previous documents due following. 1) prevalence overall importance as a health problem is increasing. 2) There have been enough advances field require an update, especially adapted particular needs ATS/ERS constituency....
Obstructive sleep apnea syndrome (OSAS), characterized by intermittent hypoxia/reoxygenation (IHR), is an independent risk factor for cardiovascular disease. We investigated the underlying molecular mechanisms of this association in a translational study.In novel vitro model IHR, we used HeLa cells transfected with reporter constructs and DNA binding assays master transcriptional regulators inflammatory adaptive pathways (NFkappaB HIF-1, respectively) to investigate events initiated repeated...
Grading the strength of recommendations and quality underlying evidence enhances usefulness clinical practice guidelines. Professional societies other organizations, including American Thoracic Society (ATS), should reach consensus about whether they will use one common grading system which numerous systems would apply across all The profusion guideline confuses consumers guidelines, undermines value exercise in conveying a transparent message. In response to this dilemma, international...
Background: Circulating nuclear factor-κB (NF-κB)–dependent genes, particularly tumor necrosis factor-α (TNF-α), are elevated in obstructive sleep apnea syndrome (OSAS) and likely contribute to cardiovascular disease. Furthermore, TNF-α is associated with excessive daytime sleepiness. We investigated the predictors of related genes large, well-selected cohorts subjects OSAS control subjects.Methods: performed a prospective study 30 who did not have (22 nonsleepy normal 8 sleepy nonapneic...
Abstract Obstructive sleep apnoea syndrome (OSAS) is a highly prevalent disease and recognised as major public health burden. Large-scale epidemiological studies have demonstrated an independent relationship between OSAS various cardiovascular disorders. The pathogenesis of complications in not completely understood but multifactorial aetiology likely. Inflammatory processes emerged critical the atherosclerosis at all stages atheroma formation. Increased levels circulating markers...
The complexity of central breathing disturbances during sleep has become increasingly obvious. They present as apnoeas (CSAs) and hypopnoeas, periodic with apnoeas, or irregular in patients cardiovascular, other internal neurological disorders, can emerge under positive airway pressure treatment opioid use, at high altitude. As yet, there is insufficient knowledge on the clinical features, pathophysiological background consecutive algorithms for stepped-care treatment. Most recently, it been...
This article is aimed at addressing the current state-of-the-art in epidemiology, pathophysiology, diagnostic procedures and treatment options for appropriate management of obstructive sleep apnoea (OSA) cardiovascular (in particular hypertensive) patients, as well diseases arterial hypertension) OSA patients. The present document result work performed by a panel experts participating European Union COST (Cooperation Scientific Technological research) Action B26 on OSA, with endorsement...
The possible role of high nasal airway resistance in the pathogenesis obstructive sleep apnea has been examined 7 patients with seasonal (ragweed) allergic rhinitis, a naturally occurring model reversible obstruction. Measurements and overnight polysomnographic studies were performed during ragweed season when complained obstruction; 6 to 8 wk later symptoms had subsided (control study). During symptomatic phase, mean (+/- SE) was 4.9 +/- 0.8 cm H2O/L/s, experienced 1.7 0.3 apneas per hour...
Section:ChooseTop of pageAbstract <<ROLE OF SYSTEMIC INFLAMMA...CARDIOVASCULAR DISEASE IN...EPIDEMIOLOGICAL CONSIDERA...PATHOPHYSIOLOGY SLEEP-...OVERLAPPING MECHANISMS OF...FUTURE RESEARCH DIRECTION...ReferencesCITING ARTICLES
This article is aimed at addressing the current state of art in epidemiology, pathophysiology, diagnostic procedures and treatment options for appropriate management obstructive sleep apnea (OSA) cardiovascular (particularly hypertensive) patients, as well diseases arterial hypertension) OSA patients. The present document result work done by a panel experts participating European Union COST (COoperation Scientific Technological research) ACTION B26 on OSA, with endorsement Respiratory...
We studied the effect of supplemental nocturnal oxygen on blood gases in 15 patients with severe but stable chronic obstructive lung disease (ratio forced expired volume one second to vital capacity, 37.2 +/- 1.8 [mean S.E.] per cent predicted; arterial tension, 50.7 1.4 mm Hg; and carbon dioxide tension [PCO2], 53.1 1.5 Hg). Sleep variables measures gas exchange were determined two consecutive nights; first night subjects breathed oxygen, they room air. Transcutaneous PCO2 was measured an...
Summary The European Sleep Research Society aimed to estimate the prevalence, determinants and consequences of falling asleep at wheel. In total, 12 434 questionnaires were obtained from 19 countries using an anonymous online questionnaire that collected demographic sleep‐related data, driving behaviour, history drowsy accidents. Associations quantified multivariate logistic regression. average prevalence wheel in previous 2 years was 17%. Among respondents who fell asleep, median accidents...