A5074347972- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Migraine and Headache Studies
- Cerebrospinal fluid and hydrocephalus
- Traumatic Brain Injury and Neurovascular Disturbances
- Restless Legs Syndrome Research
- Genetic Neurodegenerative Diseases
- Botulinum Toxin and Related Neurological Disorders
- Cardiovascular Syncope and Autonomic Disorders
- Spinal Dysraphism and Malformations
- Animal Nutrition and Physiology
- Neurological Complications and Syndromes
- Psychosomatic Disorders and Their Treatments
- Trigeminal Neuralgia and Treatments
- Fetal and Pediatric Neurological Disorders
- Neurological diseases and metabolism
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurosurgical Procedures and Complications
- RNA regulation and disease
- Sleep and Wakefulness Research
- MicroRNA in disease regulation
- Advanced Neuroimaging Techniques and Applications
- Selenium in Biological Systems
- Attention Deficit Hyperactivity Disorder
- Dysphagia Assessment and Management
Istituto delle Scienze Neurologiche di Bologna
2015-2025
University of Bologna
2016-2025
Ospedale Bellaria
2021-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2012-2024
Azienda Ospedaliera Universitaria Pisana
2023
Institute of Neurological Sciences
2012-2022
Azienda Unita' Sanitaria Locale Di Modena
2016-2020
Sapienza University of Rome
2016-2020
Mayo Clinic
2019
University College London
2019
The clinical diagnosis of synucleinopathies, including Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA), is challenging, especially at an early stage, due to the heterogeneous often non-specific manifestations. discovery reliable specific markers for synucleinopathies would consequently be great aid management these disorders. Real-Time Quaking-Induced Conversion (RT-QuIC) ultrasensitive technique that has been previously used detect...
Objective:The aims of the present study were to profile expression several candidate microRNAs (miRNAs) in blood from l-dopa-treated and drug-naive patients with Parkinson disease (PD) vs unaffected controls interpret miRNA data a biological context.Methods:We analyzed RNAs peripheral 36 l-dopa–treated, 10 PD matched 1:1 by sex age. We evaluated reverse transcription–quantitative real-time PCR, we using 2-tailed paired t test. To detect targets, resources combined generate an overall score...
Neurofilament light chain (NfL) and α-synuclein oligomeric seeds (α-syn-s) are promising biomarkers for patients with parkinsonism. We assessed their performance in discriminating Parkinson disease (PD) from atypical parkinsonisms (APDs) evaluated the association between NfL levels clinical measures of severity. measured cerebrospinal fluid (CSF) and/or plasma by immunoassays α-syn-s CSF real-time quaking-induced conversion (RT-QuIC) PD (n = 153), multiple system atrophy (MSA) 80),...
<h3>Objective:</h3> To evaluate the predictive value of stridor and its latency onset to investigate role treatment in a cohort patients with multiple system atrophy (MSA) referred tertiary center. <h3>Methods:</h3> We retrospectively identified diagnosed MSA our department beginning 1991 evaluated at least yearly during disease course. Stridor was defined as present when confirmed by whole night video-polysomnography early if presenting within 3 years onset. Survival data, from time death,...
The risk of COVID-19 and related death in people with Parkinson's disease or parkinsonism is uncertain. aim the study was to assess hospitalization for a cohort patients compared control population cohort, during epidemic bout (March-May 2020) Bologna, northern Italy.Participants ParkLink clinical diagnosis anonymously matched (ratio 1:10) sex, age, district, Charlson Index were included. hospital admission rate (February 26-May 31, any cause outcomes interest.The included 696 subjects 184...
Background GBA variants increase the risk of developing Parkinson disease (PD) and influence its outcome. Deep brain stimulation (DBS) is a recognised therapeutic option for advanced PD. Data on DBS long-term outcome in carriers are scarce. Objective To elucidate impact large Italian cohort. Methods We retrospectively recruited multicentric DBS-PD cohort assessed: (1) prevalence; (2) pre-DBS clinical features; (3) outcomes motor, cognitive other non-motor features up to 5 years post-DBS....
Headache and epilepsy are two relatively common neurological disorders their relationship is still a matter of debate. Our aim was to estimate the prevalence clinical features inter-ictal (inter-IH) peri-ictal headache (peri-IH) in patients with epilepsy. All aged ≥ 17 years referring our tertiary Epilepsy Centre were consecutively recruited from March May 2011 July 2012. They underwent semi-structured interview including International Classification Disorders (ICHD-II) criteria diagnose...
To investigate (1) the prevalence of REM sleep behavior disorder (RBD) as mode disease onset in a cohort patients with multiple system atrophy (MSA) and (2) progression prognosis MSA RBD predating (pre-RBD) following (post-RBD) onset.We retrospectively identified all clinical diagnosis evaluated at least once year during course. Type was defined by first reported motor or autonomic symptom/sign related to MSA. The occurrence symptoms/signs milestone progression, their latency from onset,...
Levodopa (LD) is the main treatment for parkinsonism, but its use may be limited by a potential hypotensive effect.
Abstract Background Early stridor onset (≤ 3 years from disease onset) is a predictor of shorter survival in Multiple System Atrophy (MSA), but its role on progression not yet established. In MSA, previous studies trajectories did include and REM sleep behavior disorder (RBD) as clinical variable. The aims the study were: (1) to investigate MSA patients with early and/or RBD onset; (2) assess cerebrospinal fluid (CSF) levels neurofilament light chain protein (NfL) disorders. Methods This...
Purpose: To evaluate the peripapillary area in eyes of patients with Idiopathic Normal Pressure Hydrocephalus (iNPH) before and after shunt surgery. Methods: Twenty iNPH were prospectively recruited. Enhance depth imaging-optical coherence tomography (EDI-OCT) was performed to image region. Using a 360-degree 3.4 mm diameter circle scan, choroidal thickness (PPCT) manually measured compared 20 healthy-age-matched controls. PPCT assessed at least 6 months from VP surgery 12 patients. Results:...
Isolated REM sleep behavior disorder (iRBD) is a prodromal state of α-synucleinopathies, presenting years before overt neurodegenerative disorders. Autonomic nervous system (ANS) involvement, particularly cardiovascular autonomic failure, may indicate progression. However, its role as (multidimensional) marker for disease progression and phenoconversion remains unclear. This study aimed to investigate whether failure symptoms dysfunction serve multidimensional markers in patients with iRBD....
Drug withdrawal still remains the key element in treatment of Medication Overuse Headache (MOH), but there is no consensus about procedure. Still debated role steroid therapy. The aim this study was to evaluate effectiveness methylprednisolone or paracetamol headache MOH. We performed a pilot, randomized, single-blinded, placebo controlled trial. MOH patients, unresponsive 3 months prophylaxis, underwent therapy on an inpatient basis. Overused medications were abruptly stopped and 500 mg i.v...
To determine the postoperative attempted and completed suicide rates after subthalamic nucleus deep brain stimulation (STN-DBS) in a single-center cohort to factors associated with suicide.We retrospectively included all patients Parkinson disease (PD) who underwent bilateral STN-DBS surgery at Grenoble University Hospital between 1993 2016. For each patient committed or suicide, 2 PD without any suicidal behaviors were matched for age (±1 year), sex, year of (±2 years). Clinical data...
<h3>Objective</h3> To retrospectively describe clinical and instrumental features of a cohort patients with at least 5-year history idiopathic autonomic failure (IAF) longitudinally evaluated the Autonomic Unit University Bologna (IAF-Bo cohort). <h3>Methods</h3> We identified IAF who were referred to our department from 1989 2016 once year during disease course. Clinical data collected medical records. variables categorized as early if presenting within 3 years onset. Predictors associated...