A5027442205- Parkinson's Disease Mechanisms and Treatments
- Cardiovascular Syncope and Autonomic Disorders
- Heart Rate Variability and Autonomic Control
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Sleep and Wakefulness Research
- Restless Legs Syndrome Research
- Neuroscience of respiration and sleep
- Blood Pressure and Hypertension Studies
- Glioma Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- Neurological diseases and metabolism
- Non-Invasive Vital Sign Monitoring
- Urticaria and Related Conditions
- Hidradenitis Suppurativa and Treatments
- Colorectal Cancer Treatments and Studies
- Obstructive Sleep Apnea Research
- Autoimmune and Inflammatory Disorders
- Cerebrospinal fluid and hydrocephalus
- Functional Brain Connectivity Studies
- Eosinophilic Esophagitis
- IL-33, ST2, and ILC Pathways
- Lysosomal Storage Disorders Research
- Hereditary Neurological Disorders
- Dysphagia Assessment and Management
Istituto delle Scienze Neurologiche di Bologna
2011-2025
University of Bologna
2011-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2015-2024
Azienda Unita' Sanitaria Locale Di Modena
2016-2020
Institute of Neurological Sciences
2014-2018
Queen Elizabeth Hospital
2016
Lewisham and Greenwich NHS Trust
2016
Queen Elizabeth Hospital
2016
University of Naples Federico II
2001
<h3>Objective:</h3> To evaluate the predictive value of stridor and its latency onset to investigate role treatment in a cohort patients with multiple system atrophy (MSA) referred tertiary center. <h3>Methods:</h3> We retrospectively identified diagnosed MSA our department beginning 1991 evaluated at least yearly during disease course. Stridor was defined as present when confirmed by whole night video-polysomnography early if presenting within 3 years onset. Survival data, from time death,...
To investigate (1) the prevalence of REM sleep behavior disorder (RBD) as mode disease onset in a cohort patients with multiple system atrophy (MSA) and (2) progression prognosis MSA RBD predating (pre-RBD) following (post-RBD) onset.We retrospectively identified all clinical diagnosis evaluated at least once year during course. Type was defined by first reported motor or autonomic symptom/sign related to MSA. The occurrence symptoms/signs milestone progression, their latency from onset,...
Isolated REM sleep behavior disorder (iRBD) is a prodromal state of α-synucleinopathies, presenting years before overt neurodegenerative disorders. Autonomic nervous system (ANS) involvement, particularly cardiovascular autonomic failure, may indicate progression. However, its role as (multidimensional) marker for disease progression and phenoconversion remains unclear. This study aimed to investigate whether failure symptoms dysfunction serve multidimensional markers in patients with iRBD....
<h3>Objective</h3> To retrospectively describe clinical and instrumental features of a cohort patients with at least 5-year history idiopathic autonomic failure (IAF) longitudinally evaluated the Autonomic Unit University Bologna (IAF-Bo cohort). <h3>Methods</h3> We identified IAF who were referred to our department from 1989 2016 once year during disease course. Clinical data collected medical records. variables categorized as early if presenting within 3 years onset. Predictors associated...
The upright posture strengthens the coupling between heart period (HP) and systolic arterial pressure (SAP) consistently with a greater contribution of baroreflex to cardiac control, while paradoxically decreasing sensitivity (cBRS). To investigate physiological mechanisms that mediate HP SAP in response different postures, we analyzed cross-correlation functions low-frequency fluctuations estimated cBRS sequence technique healthy male subjects during passive head-up tilt test (HUTT, n =...
OBJECTIVE One of the more serious risks in treatment third ventricle craniopharyngiomas is represented by hypothalamic damage. Recently, many papers have reported expansion indications for endoscopic endonasal approach (EEA) to be used these tumors as well. The aim this study was assess outcome sleep-wake cycle and body core temperature (BCT), both depending on control, patients affected involving that were surgically treated via an EEA. METHODS All consecutive adult with at one center EEA...
Background: Increased prevalence of cardiovascular autonomic failure might play a key role on Parkinson’s disease (PD) progression glucocerebrosidase gene (GBA)-mutated patients, determining malignant phenotype in these patients. Objective: To objectively characterize, for the first time, profile GBA-mutated patients compared to idiopathic PD by means reflex tests (CRTs). Methods: This is case-control (1 : 2) study belonging well-characterized prospective cohorts. For each patient carrying...
Abstract Background and purpose Stridor treatment in multiple system atrophy (MSA) mainly comprises tracheostomy or continuous positive airway pressure (CPAP), but guidelines for the use of these treatments are lacking. The aim study was to evaluate predictive value stridor an MSA cohort. Methods This is a retrospective prospective monocentric cohort including patients evaluated at least once year during disease course. video‐polysomnography confirmed. time (CPAP tracheostomy) latency from...
Lack of nighttime blood pressure (BP) reduction by 10-20% from the mean daytime values (dipping) has been described as a distinguishing feature essential hypertension and associated, also in normotensive subjects, with increased cardiovascular (CV) risk. Mechanisms involved loss nocturnal dip are still unclear, but involvement autonomic nervous system (ANS) activity probably plays crucial role. Sleep is fundamental modulating ANS to maintain physiological BP circadian rhythm, for this reason...
Pure autonomic failure is challenging as it can be the presenting feature of a central nervous system syncleinopathy such Parkinson's disease (PD) or multiple atrophy (MSA). Because prognosis MSA and PD so different, predictive features for possible conversion extremely valuable. In this paper, we report three cases (two with autopsy-proven diagnosis) that had isolated AF many years before converting to PD. Of all tests were performed during premotor stage,...