A5051729881- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Restless Legs Syndrome Research
- Genetic Neurodegenerative Diseases
- Botulinum Toxin and Related Neurological Disorders
- Muscle activation and electromyography studies
- Sleep and Wakefulness Research
- Neuroscience and Neural Engineering
- Assistive Technology in Communication and Mobility
- Stroke Rehabilitation and Recovery
- Autism Spectrum Disorder Research
- Cerebral Palsy and Movement Disorders
- Dysphagia Assessment and Management
- Cannabis and Cannabinoid Research
- Alzheimer's disease research and treatments
- Behavioral and Psychological Studies
- Neurological and metabolic disorders
- Pediatric health and respiratory diseases
- Transcranial Magnetic Stimulation Studies
- Ergonomics and Musculoskeletal Disorders
- Autoimmune Neurological Disorders and Treatments
- Forensic Toxicology and Drug Analysis
- Phosphodiesterase function and regulation
- Balance, Gait, and Falls Prevention
- Parkinson's Disease and Spinal Disorders
Istituti di Ricovero e Cura a Carattere Scientifico
2013-2024
Istituto delle Scienze Neurologiche di Bologna
2013-2024
University of Bologna
2005-2020
Institute of Neurological Sciences
2015-2018
Ospedale Bellaria
2015
Istituto Ortopedico Rizzoli
2009
Objective In current clinical practice, assessment of levodopa-induced dyskinesias (LIDs) in Parkinson's disease (PD) is based on semiquantitative scales or patients' diaries. We aimed to assess the feasibility, validity, and usability a waist-worn inertial sensor for discriminating between LIDs physiological sway both supervised unsupervised settings. Methods Forty-six PD patients l-dopa therapy, 18 de novo patients, healthy controls were enrolled. Patients underwent motor signs...
Background: Different studies, mostly with limited cohorts, have suggested the effects of patients’ characteristics on levodopa (LD) pharmacokinetics. Objective: We primarily aimed at investigating in a large population relationship between features and LD kinetic variables, to assess main demographic clinical predictors Methods: The study was retrospective, based data collected from subjects parkinsonism chronic undergoing therapeutic monitoring (TM). TM includes serial quantitative motor...
Parkinson disease (PD) is characterized by a clear beneficial motor response to levodopa (LD) treatment. However, with progression and longer LD exposure, drug-related fluctuations usually occur. Recognition of the individual relationship between concentration its effect may be difficult, due complexity variability mechanisms involved. This work proposes an innovative procedure for automatic estimation pharmacokinetics pharmacodynamics parameters, biologically-inspired mathematical model. An...
This paper describes the second part of PASSO (Parkinson smart sensory cues for older users) project, which designs and tests an innovative haptic biofeedback system based on a wireless body sensor network using smartphone different smartwatches specifically designed to rehabilitate postural disturbances in persons with Parkinson's disease. According scientific literature use devices transmit cues, vibrotactile feedback (particularly trunk) seems promising improving people's gait posture...
Subthalamic (STN) local field potentials (LFPs) in the beta band are considered potential biomarkers for closed-loop deep brain stimulation (DBS) Parkinson's disease (PD). The is further dissected into low-and high-frequency components with somewhat different functions, although their concomitance and association single patient far to be defined. We present a 56-year-old male PD undergoing DBS showing double-beta peak activity on both sides. aim of study was investigate how high-beta peaks...
Objectives We compared levodopa (LD) kinetic-dynamic profile of a dose LD/aromatic amino acid decarboxylase peripheral inhibitors versus nominally equivalent commercial Mucuna pruriens (Mucuna) seeds extract in 2 patients with Parkinson disease chronically taking LD standard combined self-prescribed Mucuna. Methods Patients were challenged fasting morning 100 mg LD/25 carbidopa (patient 1) or benserazide 2) from capsules different sessions, after 12-hour formulations' washout. They underwent...
Objective: The aim of the study was to investigate potential effect short, moderate intensity (≤70% maximum heart rate) cyclette exercise on levodopa (LD)/dopa decarboxylase inhibitor bioavailability and motor response in a subgroup Parkinson disease (PD) patients presenting moderate-to-severe delay fasting morning LD dose absorption matched response. Methods: Ten underwent an oral instrumental kinetic-dynamic test based simultaneous serial measurements plasma concentrations, finger tapping...
Differential diagnosis between Parkinson's disease (PD) and atypical parkinsonisms (APs) may be difficult at onset. The response to levodopa (LD) is a key supportive feature but its definition largely empirical. Studies evaluating this issue by quantitative tests are scanty.We aimed assess the utility of subacute low LD dose kinetic-dynamic test in differential PD APs. It was applied baseline prospective follow-up patients with parkinsonian signs within three years motor onset ("BoProPark"...
Abstract Background The efficacy of subthalamic stimulation on axial signs Parkinson's disease (PD) is debated in the literature. This study delves into dynamic interplay gait and posture, specifically probing their nuanced response to levodopa. Methods We used wearable sensor technology examine alterations spatiotemporal parameters posture individuals with PD before 6 months after deep brain (STN‐DBS) surgery. Thirty‐three subjects were evaluated two pre‐operative four post‐operative...
. Recent innovative neurostimulators allow recording local field potentials (LFPs) while performing motor tasks monitored by wearable sensors. Inertial sensors can provide quantitative measures of impairment in people with subthalamic nucleus deep brain stimulation. To the best our knowledge, there is no validated method to synchronize inertial and without an additional device. This study aims define a new synchronization analyze disease-related activity patterns during specific evaluate how...
Limited data are available in clinical settings on the pharmacokinetics of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). We investigated use cannabis-based products neurological practice, monitoring patients' steady-state cannabinoids (CBs) plasma concentrations matched with different preparations.This was a prospective, single-center, observational study. Patients underwent venous blood withdrawal before CBs' morning dose then 2.5 h post-dosing. Spasticity or pain were patient...